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| 1 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 2 | Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice显示文摘 | Von der Thusen Jan H Van Berkel Theo JC Biessen Erik AL | 2001 | Circulation2001，103，8： | 1 |
| 3 | Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock 显示文摘 | Edwin S Theo JC Johan Kuiper | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
| 4 | Drug targeting by neolipoproteins显示文摘 | Theo Jc Marc CM Bijsterhusch | 1996 | J Ceontrolled Relese1996，41，1： | 1 |
| 5 | Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock显示文摘 | Edwin S Theo JC Johan K | 2003 | Clin Microbiol Rev2003，16，： | 1 |
| 6 | Receptors,Mediators,and Mechanisms Involved in Bacterial Sepsis and Septic Shock显示文摘 | Edwin S Theo JC Johan K | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
| 7 | Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E deficient and low-density lipoprotein receptor deficient mice 显示文摘 | Jan H vonder MD Theo JC | 2001 | Circulation2001，103，： | 1 |
| 8 | Drug targeting by neolipoprotein显示文摘 | Theo JC Marc CM Bijsterbosch | 1996 | J Controlled Release1996，41，1： | 1 |
| 9 | Receptors, Mediators, and Mechanisms Involvedin Bacterial Sepsis and Septic shock 显示文摘 | Edwin S Van Amersfoort Theo JC Van Berkel Johan Kuiper | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
| 10 | Drug targeting by neo-lipoproteins显示文摘 | Theo JC Marc CM Bijsterbosch MK | 1996 | J Controlled Release1996，41，1： | 1 |
| 11 | Receptors,Mediators,and Mechanisms Involved in Bacterial Sepsis and Septic shock显示文摘 | Edwin S Van Amersfoort Theo JC Van Berkel Johan Kuiper | 2003 | Clin Micmbiol Rev2003，16，3： | 1 |
| 12 | Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low- density lipoprotein receptor-deficient mice 显示文摘 | Von der Thusen Jan H Van Berkel Theo JC Biessen Erik AL | 2001 | Circulation2001，103，8： | 1 |
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