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| 1 | Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia显示文摘BACKGROUND: Chronic hepatitis C virus(HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin(anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.METHODS: Ninety-three consecutive patients(62 males and 31 females) with chronic HCV infection, who had never received antiviral therapy or recombinant EPO, were enrolled in the study. Circulating anti-EPO were detected in the serum by using an ELISA assay. Quantitative determination of serum EPO levels was done by radioimmunoassay. HCV RNA viral load measurement and genotype sequencing were also performed.RESULTS: Circulating anti-EPO were detected in 10.8% of HCV-infected patients and the prevalence of anti-EPO was significantly higher in patients with anemia(19.4% vs 5.3%, P=0.040) compared to that in those without anemia. Compared to anti-EPO negative cases, anti-EPO positive patients had higher frequency of anemia(70.0% vs 34.9%, P=0.030), lower EPO concentrations(median 16.35 vs 30.65 m U/m L, P=0.005), and higher HCV RNA viral load(median 891.5×103 vs 367.5×103 IU/m L, P=0.016). In multivariate regression analysis the presence of anti-EPO remained an independent predictor of anemia(adjusted OR: 14.303, 95% CI: 1.417-36.580, P=0.024). EPO response to anemia was less prominent among anti-EPO positive patients(P=0.001).CONCLUSIONS: Circulating anti-EPO are detected in a significant proportion of treatment-na?ve HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia. | Aristotelis Tsiakalos Theoharis Voumvas Alexandros Psarris Christina K Oikonomou Dimitrios C Ziogas Ioannis Ketikoglou Grigorios Hatzis Nikolaos V Sipsas | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 4 |
| 2 | A fast depth-buffer-based voxelization algorithm显示文摘 | Karabassi Evaggelia-Aggeliki Papaioannou Georgios Theoharis Theoharis | 1999 | Journal of Graphics Tools1999，4，4： | 1 |
| 3 | An investigation of electrolytic coloring process of anodized aluminum coatings显示文摘 | Tsangaraki-Kaplanoglou I Theohari S Dimogerontakis Th Kallithrakas-Kontos N | 2006 | Surface and Coatings Technology2006，201，6： | 1 |
| 4 | Immunohistochemical study of PTEN and phosphorylated mTOR proteins in familial and sporadic invasive breast carcinomas显示文摘 | Bakarakos P Theohari I Nomikos A | 2010 | Histopathology2010，56，： | 1 |
| 5 | Virtual Archaeologist: Assembling the Past显示文摘 | Papaioannou G Karabassi E A Theoharis T | 2001 | IEEE Computer Graphics and Appli- cations2001，21，2： | 1 |
| 6 | Prognostic significance of phosphorylated STAT-1 expression in premenopausal and postmenopausal patients with invasive breast cancer 显示文摘 | Magkou C Giannopoulou I Theohari I | 2012 | Histopathology2012，60，7： | 1 |
| 7 | Histologic changes in the human vein wall adjacent to indwelling central venous catheters 显示文摘 | Forauer AR Theoharis C | 2003 | J Vasc Interv Radiol2003，14，91： | 1 |
| 8 | Using Facial Symmetry to Handle Pose Variations in Real-World 3D Face Recognition显示文摘 | Georgios Passalis Panagiotis Perakis Theoharis Theoharis | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，，10： | 1 |
| 9 | The effects of plant flant flavonoids on mammalian cells 显示文摘 | Middleton E J Kandaswami C Theoharis C | 2000 | Pharmacol Rev2000，52，4： | 1 |
| 10 | Jugular vein catbeter placement:Histologic features and development of catheter- related (fibrin) sheaths in a swine model显示文摘 | Forauer AR Theoharis CG Dasika NL | 2006 | Radiology2006，240，： | 1 |
| 11 | Jugular vein catheter placement:Histologic features and development of catheter-related(fibrin) sheaths in a Swine Model显示文摘 | Forauer AR Theoharis CGA Dasika NL | 2006 | Radiology2006，240，： | 1 |
| 12 | Intraclass re- trieval of nonrigid 3D objects: application to face rec- ognition显示文摘 | Passalis G Kakadiaris I Theoharis T | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，2： | 1 |
| 13 | Reconstruction of three-dimensional objects through matching of their parts显示文摘 | Papaioannou G Karabassi E A Theoharis T | 2002 | IEEE Transactions on PAMI2002，24，1： | 1 |
| 14 | Mast Cells in Allergic and Inflammatory Diseases显示文摘 | Nikolaos Sismanopoulos Danae-Anastasia Delivanis Konstantinos-Dionysios Alysandratos Asimenia Angelidou Anastasia Therianou Dimitrios Kalogeromitros Theoharis C. Theoharides | 2012 | Current Pharmaceutical Design2012，，16： | 1 |
| 15 | Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcino gen, perfluorooctanoic acid显示文摘 | THEOHARIS P IRINA G S DAN G | 2001 | Toxicology and Applied Pharmacology2001，173，1： | 1 |
| 16 | Inter- stitial cystitis: bladder pain and beyond 显示文摘 | THEOHARIS C T KRISTINE W EDWARD S | 2008 | Expert Opin Phar- macother2008，9，17： | 1 |
| 17 | A fast depth- buffer-based voxelization algorithm显示文摘 | KARABASSI E A PAPAIOANNOU G THEOHARIS T | 1999 | Journal of Graphics Tools1999，4，4： | 1 |
| 18 | Using facial symmetry to handle pose variations in realworld 3D face recognition显示文摘 | Georgios Passalis Panagiotis Perakis Theoharis Theoharis | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，10： | 1 |
| 19 | PTK : A novel depth buffer-based shape descriptor for three-dimensional object retrieval显示文摘 | Georgios Passalis Theoharis Theoharis Ioannis A Kakadiaris | 2007 | Visual Comput2007，23，： | 1 |
| 20 | A fast depth buffer based voxelization algorithm 显示文摘 | Karabassi E A Papaioannou G Theoharis T | 1999 | Journal of Graphics Tools1999，4，4： | 1 |
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