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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Studies on the electrochemical behavior of a eystine self-assembled monolayer modified electrode using ferro- cyanide as a probe 显示文摘 | Valber A Pedrosa Thiago R L C Paixlio Renato S Freire | 2007 | J Electroanal Chem2007，602，2： | 1 |
| 4 | A multidimensional approach to information security risk management using FMEA and fuzzy theory显示文摘 | Maisa Mendon?a Silva Ana Paula Henriques de Gusm?o Thiago Poleto Lúcio Camara e Silva Ana Paula Cabral Seixas Costa | 2014 | International Journal of Information Management2014，，： | 1 |
| 5 | Fabrication of disposable vohammetric electronic tongues by using Prussian Blue films electrodeposited onto CD-R gold surfaces andrecognitio of milk adulteration显示文摘 | Thiago R L C Paixao Mauro Bertotti | 2009 | Sensors and Actuators B2009，137，： | 1 |
| 6 | Towards an integrated computational tool for spatial analysis in macroecology and biogeography显示文摘 | Thiago F L Jose A F Luis M B | 2006 | Globle Ecology and Biogeography2006，15，： | 1 |
| 7 | Use of Copper and Gold Electrodes as Sensitive Elements for Fabrication of an Electronic Tongue:Discrimination of Wines and Whiskies显示文摘 | Wander N Mauro B Thiago R L C | 2011 | Micrhemical lournal2011，99，1： | 1 |
| 8 | On the performances of lead dioxide and boron-doped diamond electrodes in the anodic oxidation of simulated wastewater containing the Reactive Orange 16 dye 显示文摘 | Leonardo S Andrade Thiago T Tasso Diego L da Silva | 2009 | Electrochimica Acta2009，54，： | 1 |
| 9 | Synthe-sis and Properties of Epoxy Resin Modified with Epoxy-ter-minated Liquid Polybutadiene显示文摘 | Barcia Fabio L Amaral Thiago P Soares Bluma G | | 0，，： | 1 |
| 10 | Determination ofnitrate in mineral water and sausage samples hying a renewable in situ oopper modified electrode 显示文摘 | Thiago R Jutiana L Cardoso b' Mauro Bertotti | 2006 | Talanta2006，5，7： | 1 |
| 11 | Direct nitrate sensing in water using an array of copper-microelectrodes from flat flexible cables显示文摘 | Iranaldo S. da Silva William R. de Araujo Thiago R.L.C. Paix?o Lúcio Angnes | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 12 | On the performances of lead dioxide and boron-doped diamond electrodes in the anodic oxidation of simulated wastewater containing the Reactive Orange 16 dye 显示文摘 | Leonardo S A Thiago T T Diogo L S | 2009 | Electrochimica Acta2009，54，： | 1 |
| 13 | The use of a copper microelectrode to measure the ethanol content in gasohol samples 显示文摘 | PAIXAO THIAGO R L C CARDOSO J L BERTOTTI M | 2007 | Fuel2007，86，7： | 1 |
| 14 | New parenteral lipid emulsion for clinical use显示文摘 | DAN L W RAQUEL S T THIAGO M J | 2006 | JPEN2006，30，4： | 1 |
| 15 | Use of Copper and Gold Electrodes as Sensitive Elements for Fabrication of an Electronic Tongue: Discrimination of Wines and Whiskies显示文摘 | Wander N Mauro B Thiago R L C | 2011 | Microchemical Journal2011，99，1： | 1 |
| 16 | Fabrication of disposable vol- tammetrie electronic tongues by using Prussian Blue films eleetrodeposited onto CD-R gold surfaces and recognition of milk aduheration显示文摘 | Thiago R L C Paixao M B | 2009 | Sensors and Actuators B2009，137，1： | 1 |
| 17 | Determination ofnitrate inmineral water and sausage samples by using a renewable in situ coppermodified electrode 显示文摘 | Thiago R C Juliana L C Mauro B | 2006 | Talanta2006，，9： | 1 |
| 18 | Management of Ventilator-As- sociated Pneumonia显示文摘 | Emili D Marta U Thiago L | 2009 | Infect Dis Clin N Am2009，23，： | 1 |
| 19 | Studies on the electrochemical behavior of a cystine self-assembled monolayer modified electrode using ferrocyanide as a probe显示文摘 | Valber A Pedrosa Thiago R L C Paixao Renato S Freire et at | 2007 | Journal of Electroanalytical Chem- istry2007，602，2： | 1 |
| 20 | Synthesis and evaluation of anti Toxoplasma gondiiand antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles显示文摘 | André P L Thiago M A Cristiane S C | 2010 | Eur J Med Chem2010，45，： | 1 |
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