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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | 3D numerical simulation of seagrass movement under waves and currents with GPUSPH显示文摘The current study tries a new approach to simulating interactions between waves and seagrass through Smoothed Particle Hydrodynamics(SPH).In this model,the plants are defined as a solid that respects Hooke's law,and are assumed to have direct interaction with the fluid.Given the characteristics of the SPH method,especially in terms of computational time,the dimensions of the simulations were limited.The first goal of the current study was to optimize the approach to avoid reaching certain limits such as the rupture of the simulated plant.Plant movements under waves and/or currents have been studied by several authors in various in-situ,physical,and numerical experiments concerning various vegetation species,thus proving that plant movements can be successfully reproduced by SPH 2D/3D.Manning's roughness coefficient,n,was calculated to confirm that the results were in accordance with what had been measured in flume studies.Even though there is still room for improvement,it is shown that this method can be used to estimate Manning's coefficient for coastal vegetation(seagrass and saltmarsh vegetation)and to greatly improve the modeling and forecasting of coastal erosion and storm surge risks by including the effects of vegetation in integrated models. | Anne-Eleonore Paquier Thibault Oudart Caroline Le Bouteiller Samuel Meule Philippe Larroude Robert A.Dalrymple | 2021 | International Journal of Sediment Research2021，36，6： | 2 |
| 3 | Dynamic mechanical deformation of neurons triggers an acute calcium response and eell injury involving the N-methyl-D-aspartate glutamate receptor显示文摘 | LaPlaca MC Thibault LE | 1998 | J Neurosci Res1998，52，： | 1 |
| 4 | Physical model simulations of brain injury in the primate 显示文摘 | Margulies SS Thibault LE Gennarelli TA | 1990 | Biomechanics1990，23，8： | 1 |
| 5 | An vitro model of traumatic neuronal injury: loading rate-dependent changes in acute cytosolic calcium and lactate dehydrogenase release 显示文摘 | Laplaca MC Lee VM Thibault LE | 1997 | J Neurotrauma1997，14，6： | 1 |
| 6 | Physical model simulations of brain injury in the primate显示文摘 | Margulies SS Thibault LE Gennarelli TA | 1990 | J Biomech1990，23，8： | 1 |
| 7 | Diddose axonal injury and traumatic coma in primate 显示文摘 | Generally TA Thibault LE Adame JH | 1982 | Ann Aeurol1982，12，6： | 1 |
| 8 | Diffuse axo-nal injury and traumatic coma in the primate显示文摘 | Gennarelli TA Thibault LE Adams JH | 1982 | Ann Neu-rol1982，12，6： | 1 |
| 9 | Diffuse axonal injury andtraumatic coma in the primate显示文摘 | Gennarelli TA Thibault LE | 1982 | Ann Neurol1982，12，6： | 1 |
| 10 | An analytical model of traumat-ic diffuse brain injury显示文摘 | Margulies SS Thibault LE | 1989 | J Biomech Eng1989，111，3： | 1 |
| 11 | A proposed tolerance criterionfor diffuse axonal injury in man显示文摘 | Margulies SS Thibault LE | 1992 | J Biomech1992，25，8： | 1 |
| 12 | Diffuse axonal injury and traumatic coma in the primate 显示文摘 | Gennarelli TA Thibault LE Adams JH | 1982 | Ann Neuol1982，12，6： | 1 |
| 13 | Axonal injury in the optic nerve:a model simulating diffuse axonal injury in the brain 显示文摘 | Gennarelli TA Thibault LE Tipperman R | 1989 | J Neurosurg1989，71，2： | 1 |
| 14 | Diffuse axonal injury and traumatic coma in the primate显示文摘 | Gennarelli TA Thibault LE Adams JH | 1982 | Ann Neurol1982，12，： | 1 |
| 15 | An in vitro model of traumatic neuronal injury: Loading rate-dependent changes in acute cytosolic calcium and lactate dehydrogenase release 显示文摘 | Thibault LE | 1997 | J Neurotrauma1997，14，6： | 1 |
| 16 | Performance evaluation of COFDM for digital audiobroadcasting-part I: Parametric study 显示文摘 | Thibault L LE M T | 1997 | IEEE Trans on Broadcasting1997，43，3： | 1 |
| 17 | Ni(II) and Cu(II) binding properties of native and modified sugar beet pulp显示文摘 | Zacaria Reddad Claire Gérente Yves Andrès Marie-Christine Ralet Jean-Fran?ois Thibault Pierre Le Cloirec | 2002 | Carbohydrate Polymers2002，，1： | 1 |
| 18 | Physical model simulations of brain injury in the primate 显示文摘 | Margulies SS Thibault LE Gennarelli TA | 1990 | J Biomeeh1990，23，8： | 1 |
| 19 | Diffuse axonal injury and traumatic coma in the primate显示文摘 | Gennarelli TA Thibault LE Adams JH | 1982 | Ann Neuro1982，12，6： | 1 |
| 20 | Axonal injury in the optic nerve:a model simulating diffuse axonal injury in the brain显示文摘 | Gennarelli TA Thibault LE Tipperman R | 1989 | J Neurosurg1989，71，2： | 1 |
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