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158篇 您的检索式：作者名="Thimmulappa"

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	题名	作者	年代	出处	被引量
1	Nrf2 is required for normal postnatal bone acquisition in mice显示文摘A large body of literature suggests that bone metabolism is susceptible to the ill effects of reactive species that accumulate in the body and cause cellular dysfunction. One of the body's front lines in defense against such damage is the transcription factor, Nrf2. This transcription factor regulates a plethora of antioxidant and cellular defense pathways to protect cells from such damage. Despite the breadth of knowledge of both the function of Nrf2 and the effects of reactive species in bone metabolism, the direct role of Nrf2 in skeletal biology has yet to be thoroughly examined. Thus, in the current study, we have examined the role of Nrf2 in postnatal bone metabolism in mice. Mice lacking Nrf2(Nrf22/2) exhibited a marked deficit in postnatal bone acquisition,which was most severe at 3 weeks of age when osteoblast numbers were 12-fold less than observed in control animals. While primary osteoblasts from Nrf22/2mice functioned normally in vitro, the colony forming capacity of bone marrow stromal cells(BMSCs) from these mice was significantly reduced compared to controls.This defect could be rescued through treatment with the radical scavenger N-acetyl cysteine(NAC), suggesting that increased reactive species stress might impair early osteoblastogenesis in BMSCs and lead to the failure of bone acquisition observed in Nrf22/2animals. Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis.	Jung-Hyun Kim Vandana Singhal Shyam Biswal Rajesh K Thimmulappa Douglas J Di Girolamo	2014	Bone Research2014，2，4：	3
2	Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer显示文摘	Singh A Misra V Thimmulappa R K		0，，10：	1
3	Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress显示文摘	Harvey CJ Thimmulappa RK Singh A	2009	Free Radic Biol Med2009，46，4：	1
4	Experimental therapeutics of Nrf2 as atarget for prevention of bacterial exacerbations in COPD显示文摘	Biswal S Thimmulappa RK Harvev CJ	2012	Proc Am Thorac Soc2012，9，2：	1
5	Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress显示文摘	Mercado N Thimmulappa R Thomas CM		0，，02：	1
6	RNAimediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy显示文摘	Singh A Boldin-Adamsky S Thimmulappa R K		0，，19：	1
7	Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer 显示文摘	Singh A Misra V Thimmulappa RK	2006	PLoS Med2006，3，10：	1
8	Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke- induced emphysema in mice 显示文摘	Rangasamy T Cho CY Thimmulappa RK	2004	J Clin Invest2004，114，9：	1
9	Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs显示文摘	Thimmulappa RK Rangasamy T Alam J	2008	Med Chem2008，4，：	1
10	Nrf2 regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress显示文摘	Harvey CJ Thimmulappa RK Singh A		0，，：	1
11	Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer显示文摘	Singh A Misra V Thimmulappa RK		0，，10：	1
12	Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer 显示文摘	Singh A Misra V Thimmulappa RK	2006	PLoS Med2006，3，10：	1
13	Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide显示文摘	Thimmulappa RK Scollick C Traore K Yates M Trush MA Liby KT	2006	Biochem Biophys Res Commun2006，351，4：	1
14	Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung eaneer显示文摘	Singh A Misra V Thimmulappa RK	2006	PLoS Med2006，3，10：	1
15	Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis显示文摘	Thimmulappa RK Lee H Rangasamy T Reddy SP Yamamoto M Kensler TW	2006	J Clin Invest2006，116，4：	1
16	Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis 显示文摘	Thimmulappa RK Lee H Rangasamy T	2006	J Clin Invest2006，116，4：	1
17	Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice 显示文摘	Rangasamy T Cho C Y Thimmulappa R K	2004	J Clin Invest2004，114，：	1
18	Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice显示文摘	Rangasamy T Cho C Y Thimmulappa R K	2004	J Clin Invest2004，114，9：	1
19	Genetic abla- tion of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice显示文摘	Rangasamy T Cho CY Thimmulappa RK	2004	J Clin Invest2004，114，9：	1
20	Identification of Nrf2-regulatedgenes induced by the chemopreventive agent sulfora-phane by oligonucleotide microarray 显示文摘	Thimmulappa R K Mai K H Srisuma S?Kensler T W?Yamamoto M Biswal S	2002	Cancer Res2002，62，：	1

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