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| 1 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 3 | Proposal of a computed tomography classification for hepatic alveolar echinococcosis显示文摘AIM: To establish a computed tomography(CT)-morphological classification for hepatic alveolar echinococcosis was the aim of the study. METHODS: The CT morphology of hepatic lesions in 228 patients with confirmed alveolar echinococcosis(AE) drawn from the Echinococcus Databank of the University Hospital of Ulm was reviewed retrospectively. For this reason, CT datasets of combined positron emission tomography(PET)-CT examinations were evaluated. The diagnosis of AE was made in patientswith unequivocal seropositivity; positive histological findings following diagnostic puncture or partial resection of the liver; and/or findings typical for AE at either ultrasonography, CT, magnetic resonance imaging or PET-CT. The CT-morphological findings were grouped into the new classification scheme.RESULTS: Within the classification a lesion was dedicated to one out of five 'primary morphologies' as well as to one out of six 'patterns of calcification'. 'primary morphology' and 'pattern of calcification' are primarily focussed on separately from each other and combined, whereas the 'primary morphology' V is not further characterized by a 'pattern of calcification'. Based on the five primary morphologies, further descriptive sub-criteria were appended to types Ⅰ-Ⅲ. An analysis of the calcification pattern in relation to the primary morphology revealed the exclusive association of the central calcification with type Ⅳ primary morphology. Similarly, certain calcification patterns exhibited a clear predominance for other primary morphologies, which underscores the delimitation of the individual primary morphological types from each other. These relationships in terms of calcification patterns extend into the primary morphological sub-criteria, demonstrating the clear subordination of those criteria.CONCLUSION: The proposed CT-morphological classification(EMUC-CT) is intended to facilitate the recognition and interpretation of lesions in hepatic alveolar echinococcosis. This could help to interpret different clinical courses better and shall assist in the context of scientific studies to improve the comparability of CT findings. | Tilmann Graeter Wolfgang Kratzer Suemeyra Oeztuerk Mark Martin Haenle Richard Andrew Mason Andreas Hillenbrand Thomas Kull Thomas F Barth Peter Kern Beate Gruener | 2016 | World Journal of Gastroenterology2016，22，13： | 10 |
| 4 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 5 | Efficacy of Psychological Interventions for Sexual Dysfunction: A Systematic Review and Meta-Analysis显示文摘 | Sarah Frühauf Heike Gerger Hannah Maren Schmidt Thomas Munder Jürgen Barth | 2013 | Archives of Sexual Behavior2013，，： | 1 |
| 6 | Surgical Treatment of Post-traumatic Myelopathy Associated With Syringomyelia显示文摘 | Thomas T. Lee Gustavo J. Alameda Elizabeth Camilo Barth A. Green | 2001 | Spine (S Suppl)2001，，24： | 1 |
| 7 | Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells显示文摘 | Brian M. Barth Sally J. Gustafson Jody L. Hankins James M. Kaiser Jeremy K. Haakenson Mark Kester Thomas B. Kuhn | 2011 | Cellular Signalling2011，，： | 1 |
| 8 | Appendix Carcinoid Associated With The Peutz-Jeghers Syndrome显示文摘 | Sabine Hofmann Thomas F.E. Barth Marko Kornmann Doris Henne-Bruns | 2014 | International Journal of Surgery Case Reports2014，，： | 1 |
| 9 | Laryngeal Morbidity and Quality of Tracheal Intubation: A Randomized Controlled Trial显示文摘 | Thomas Mencke Mathias Echternach Stefan Kleinschmidt Philip Lux Volker Barth Peter K. Plinkert Thomas Fuchs-Buder | 2003 | Anesthesiology2003，，： | 1 |
| 10 | Comparison of endothelial changes and power settings between torsional and longitudinal phacoemulsification显示文摘 | Anna Reuschel Holger Bogatsch Thomas Barth Renate Wiedemann | 2010 | Journal of Cataract & Refractive Surgery2010，，11： | 1 |
| 11 | Hepatic infestation of Echinococcus multilocularis with extension to regional lymph nodes显示文摘 | Klaus Buttenschoen Peter Kern Stefan Reuter Thomas F. E. Barth | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 12 | An invasion related com-plex of cortactin,paxillin and PKCmu associates with invadopodiaat sites of extracellular matrix degradation 显示文摘 | Bowden E T Barth M Thomas D | 1999 | Oncogene1999，18，31： | 1 |
| 13 | Common-path interferometric label-free protein sensing with resonant dielectric nanostructures显示文摘Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity,low-cost,and reliable technology.Among the most sensitive modalities,interferometry offers particularly high performance,but typically lacks the required operational simplicity and robustness.Here,we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent stability.The sensor exploits the simultaneous excitation of two orthogonally polarized modes,and detects the relative phase change caused by biomolecular binding on the sensor surface.The wide dynamic range of the sensor,which is essential for fabrication and angle tolerance,as well as versatility,is controlled by integrating multiple,tuned structures in the field of view.This approach circumvents the trade-off between sensitivity and dynamic range,typical of other phase-sensitive modalities,without increasing complexity.Our sensor enables the challenging label-free detection of procalcitonin,a small protein(13 kDa)and biomarker for infection,at the clinically relevant concentration of 1 pg mL^(−1),with a signal-to-noise ratio of 35.This result indicates the utility for an exemplary application in antibiotic guidance,and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality. | Isabel Barth Donato Conteduca Christopher Reardon Steven Johnson Thomas F.Krauss | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 14 | An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation 显示文摘 | Bowden ET Barth M Thomas D | 1999 | Oncogene1999，18，31： | 1 |
| 15 | Accurate Preoperative Localization of Parathyroid Adenomas With C-11 Methionine PET/CT显示文摘 | Theresia Weber Clemens Maier-Funk Dagmar Ohlhauser Andreas Hillenbrand Gregor Cammerer Thomas F. Barth Doris Henne-Bruns Bernhard O. Boehm Sven N. Reske Markus Luster | 2013 | Annals of Surgery2013，，6： | 1 |
| 16 | Videothoracoscopy Versus Thoracotomy for the Treatment of Spontaneous Pneumothorax: A Propensity Score Analysis显示文摘 | Pierre-Benoit Pagès Jean-Philippe Delpy Pierre-Emmanuel Falcoz Pascal-Alexandre Thomas Marc Filaire Fran?oise Le Pimpec Barthes Marcel Dahan Alain Bernard | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
| 17 | An invasion related complexof cortactin,paxillin and PKCmu associates with invadopodia at sitesof extracellular matrix degradation 显示文摘 | Bowden ET Barth M Thomas D | 1999 | Oncogene1999，18，44： | 1 |
| 18 | An invasion-re- lated complex of cortactin, paxillin and PKCmu associ- ates with invadopodia at sites of extracellular matrix degradation显示文摘 | Bowden ET Barth M Thomas D | 1999 | Oncogene1999，18，31： | 1 |
| 19 | Mouse models for the study of HCV infection and virus–host interactions显示文摘 | Heidi Barth Eric Robinet T. Jake Liang Thomas F. Baumert | 2008 | Journal of Hepatology2008，，1： | 1 |
| 20 | Treatment of stable burst fracture of the atlas (Jefferson fracture) with rigid cervical collar显示文摘 | Thomas T Lee Barth AG David RP | 1998 | Spine1998，23，18： | 1 |
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