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| 1 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 3 | Endocrine hypertension:An overview on the current etiopathogenesis and management options显示文摘Endocrine causes of secondary hypertension include primary aldosteronism,pheochromocytoma,cushing's syndrome,hyperparathyroidism and hypo-and hyperthyroidism.They comprise 5%-10% of the causes of secondary hypertension.Primary hyperaldosteronism,the most common of the endocrine cause of hypertension often presents with resistant or difficult to control hypertension associated with either normo-or hypokalemia.Pheochromocytoma,a great mimicker of many conditions,is associated with high morbidity and mortality if left untreated.A complete history including pertinent family history,physical examination along with a high index of suspicion with focused biochemical and radiological evaluation is important to diagnose and effectively treat these conditions.The cost effective targeted genetic screening for current known mutations associated with pheochromocytoma are important for early diagnosis and management in family members.The current review focuses on the most recent evidence regarding causes,clinical features,methods of diagnosis,and management of these conditions.A multidisciplinary approach involving internists,endocrinologists and surgeons is recommended in optimal management of these conditions. | Reena M Thomas Ewa Ruel Prapimporn Ch Shantavasinkul Leonor Corsino | 2015 | World Journal of Hypertension2015，5，2： | 2 |
| 4 | Factitious cheilitis 显示文摘 | Thomas JR III Greene SL Dicken CH | 1983 | J Am Aead Dermatol1983，8，： | 1 |
| 5 | Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters显示文摘 | Thomas Yeung CH Yang L Huang Y | 2000 | Br J Nutr2000，84，： | 1 |
| 6 | Variation in the promoter region of the β-fibrinogen gene is associated with plasma fibrinogen levels in smokers and non-smokers 显示文摘 | Thomas AE Green FR Kelleher CH | 1991 | Thromb Haemost1991，65，5： | 1 |
| 7 | The CLC chloride channel family显示文摘 | Jents CH Thomas F | 1999 | Plugers Arch-Eur J Physiol1999，437，： | 1 |
| 8 | Remission of major depression and obsessivecompulsive disorder after a single unilateral ECT显示文摘 | Thomas SG Kellner CH | 2008 | ECT2008，24，1： | 1 |
| 9 | Genetic risk factors for early onset periodontitis显示文摘 | Thomas CH | 1996 | JPeriodontol1996，67，6： | 1 |
| 10 | Molecular modeling of the aldose-reductase inhibitors complex based on the x-ray crystal structure and studies with single-sitedirected mutants显示文摘 | Suresh BS Michael SM Thomas CH | 2000 | J Med Chem2000，43，6： | 1 |
| 11 | Current concepts in tibial plateau fractures显示文摘 | Thomas Ch Athanasiov A Wullschleger M | 2009 | Acta Chir Orthop Traumatol Cech2009，76，5： | 1 |
| 12 | Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation,osteoclast recruitment,and bone turnover显示文摘 | Cowan CM Aalami OO Shi YY Chou YF Mari C Thomas R Quarto N Nacamuli RP Contag CH Wu B Longaker MT | | 0，，： | 1 |
| 13 | Vitamin E and donepezil for the treatment of mild cognitive impairment显示文摘 | Petersen RC Thomas RG Grundman M Bennett D Doody R Ferris S Galasko D Jin S Kaye J Levey A Pfeiffer E Sano M van Dyck CH Thal LJ Alzheimer's Disease Cooperative Study Group | | 0，，23： | 1 |
| 14 | The interaction model of client health behavior as a conceptual guide in the explanation of children's health behaviors显示文摘 | Robinson CH Thomas SP | | 0，，01： | 1 |
| 15 | Analysis and modeling of flooding in urban drainage systems显示文摘 | SCHMIT? T G THOMAS M E'ITR/CH N | 2004 | Journal of Hydrology2004，299，34： | 1 |
| 16 | A novel method to fabricate biodegradable scaffolds显示文摘 | Whang K Thomas CH Healy KE | 1995 | Polymer1995，6，： | 1 |
| 17 | Current concepts in tibial plateau fractures 显示文摘 | Thomas CH Athanasiov A Wullschleger M | 2009 | Actachirorthop Traumatol Cech2009，5，： | 1 |
| 18 | Current concepts in tibial plateau fractures 显示文摘 | Thomas Ch Athanasiov A Wullschleger M | 2009 | Acta Chir Orthop Traumatol Cech2009，5，： | 1 |
| 19 | Current concepts in tibial plateau fractures 显示文摘 | Thomas CH Athanasiov A WuUschleger M etal | 2009 | Acta Chit Orthop Traumatol Cech2009，76，5： | 1 |
| 20 | Current concepts in tibial plateau fractures显示文摘 | Thomas Ch Athanasiov A Wullschleger M | 2009 | Acta Chir Orthop Traumatol Cech2009，76，5： | 1 |
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