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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 3 | Mitotic and G2 checkpoint control: regulation of 14-3-3-protein binding by phosphorylation of cdc25C on serine-216 显示文摘 | Peng CY Graves PR Thoma RS | 1997 | Science1997，277，5331： | 1 |
| 4 | Retinal vascular fractal dimension and its relationship with cardiovascular and ocular risk factors显示文摘 | Cheung CY Thomas GN Tay W Ikram MK Hsu W Lee ML | | 0，，4： | 1 |
| 5 | Importance of pathologic staging in the surgical management of adenocarcinoma of the exocine pancreas 显示文摘 | Hermreck AS Thomas CY Friesen SR | 1974 | AMJ Surg1974，127，4： | 1 |
| 6 | Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measurement by Doppler echocardiography显示文摘 | Choong CY Abascal VM Thomas JD | 1988 | Circulation1988，78，： | 1 |
| 7 | DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis 显示文摘 | Thomas DA Du CY Xu M | 2000 | Immunity2000，12，6： | 1 |
| 8 | Mitotic and G2checkpoint control: regulation of 14-3-3 protein binding byphosphorylation of Cdc25C on serine-216 显示文摘 | Peng CY Graves PR Thoma RS | 1997 | Science1997，277，： | 1 |
| 9 | Mitotic and G2 cheek-point control:regulation of 14-3-3 protein binding by phosphoryla-tion of Cdc25C on serine-216显示文摘 | Peng CY Graves PR Thoma RS | 1997 | Science1997，277，5331： | 1 |
| 10 | Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measured by Doppler echocardiography显示文摘 | Choong CY Abascal VM Thomas JD | 1988 | Circulation1988，78，3： | 1 |
| 11 | Inportance of pathologic staging in the surgical managment of adenocarcinoma of the exocrine pancreas 显示文摘 | Hermreck AS Thomas CY 4th Friesen SR | 1974 | Am J Surg1974，127，6： | 1 |
| 12 | Longitudinal changes in bone mineral density and bone turnover in postmenopausal women with primary hyperparathyroidism显示文摘 | Thomas WEG Al- Dehaimi AW | 1999 | Clin En- docrinol Metab1999，81，10： | 1 |
| 13 | Genetic markers associated with early cancer-specific mortality following prostatectomy显示文摘 | Liu W Xie CC Thomas CY | 2013 | Cancer2013，119，13： | 1 |
| 14 | Noutrophil separation technique for noonates显示文摘 | Alfred YC Tam CY Yeunq | 1999 | British Journal of Biomedical Science1999，56，3： | 1 |
| 15 | The HIV-1 Env protein signal sequence retards its cleavage and down- regulates the glycoprotein folding显示文摘 | Li Y Luo L Thomas DY Kang CY | 2000 | Virology2000，272，2： | 1 |
| 16 | Mitotic and G2 checkpoint control:regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216显示文摘 | Peng CY Graves PR Thoma RS | 1997 | Science1997，277，5331： | 1 |
| 17 | Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 显示文摘 | Peng CY Graves PR Thoma RS | 1997 | Science1997，277，5331： | 1 |
| 18 | Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measurement by Doppler echocardiography显示文摘 | Choong CY Abascal VM Thomas JD | 1988 | Circulation1988，78，： | 1 |
| 19 | Combined influence of ventricular loading and relaxation on hetrans mitral flow velocity profile in dogs measured by Doppler echocardiography显示文摘 | CHOONG CY ABASCAL VM THOMAS JD | 1988 | Circulation1988，78，： | 1 |
| 20 | Importance of pathologic staging in the surgical management of adenocarcinoma of the exocrine pancreas 显示文摘 | Hermreck AS Thomas CY 4th Friesen SR | 1974 | Am J Surg1974，127，6： | 1 |
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