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您的检索式：作者名="Thomas D.Crenshaw"
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| 1 | A simple daily dynamic feeding regimen for reducing phosphorus consumption and excretion in laying hens显示文摘Phosphorus metabolism in laying hens is a highly dynamic process over the course of the 24 h egg-laying cycle.Adjusting the phosphorus feeding regimen according to the daily egg-laying cycle may help to improve phosphorus utilization efficiency.Hy-Line Brown layers(n=120;70 wk old)were offered 4different phosphorus daily regimens:(1)RR,fed regular phosphorus at both 09:00 and 17:00;(2)RL,fed regular phosphorus at 09:00 and low phosphorus at 17:00;(3)LR,fed low phosphorus at 09:00 and regular phosphorus at 17:00;(4)LL,fed low phosphorus at both 09:00 and 17:00.The regular and low phosphorus diets contained 0.32% and 0.14% non-phytate phosphorus,respectively.The feeding trial lasted for 12 wk.As a result,layers on the RL regimen had decreased laying rate(P<0.05;5 to 8,9 to 12,and 1 to 12 wk)when compared to all other regimens.Layers on the LL regimen had decreased eggshell thickness and specific gravity(P<0.05;wk 8)when compared to all other regimens,and had decreased egg shell strength(P<0.05;wk 8)when compared to RL and LR regimens.When compared to the RR regimen(a common practice in the industry),layers on the LR regimen had:(1)identical laying performance and egg quality(P>0.05);(2)decreased phosphorus excretion(P<0.05)during the period of09:00 to 17:00;(3)increased jejunal calbindin D28k protein expression(P<0.05)2 h after feeding in the morning;(4)decreased serum fibroblast growth factor 23 and calcitriol levels(P<0.05),decreased jejunal type Ⅲ sodium-phosphate cotransporter 2 gene and protein expression(P<0.05),and decreased renal type Ⅲ sodium-phosphate cotransporter 1 protein expression(P<0.05),2 h after feeding in the afternoon.In summary,when dietary phosphorus was supplemented in accordance with daily serum phosphorus rhythms(i.e.,the LR regimen),laying performance and egg quality were well supported whilst significantly decreasing phosphorus consumption and excretion.Thus,serum phosphorus rhythms will need to be carefully maintained when developing dietary phosphorus-reduction strategies in laying hens. | Xujie Liao Jiakun Yan Jionghao Chen Zhenyu Huang Tianshuai Xiao Changqing Li Chong Pan Xin Yang Yanli Liu Thomas D.Crenshaw Xiaojun Yang Zhouzheng Ren | 2022 | Animal Nutrition2022，，4： | 2 |
| 2 | Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody显示文摘Oral antibody to interleukin-10(anti-IL-10)enhances the intestinal immune defense against Eimeria.The sulfur amino acids methionine and cysteine(MtC)play essential roles in inducing and maintaining protective immune responses during intestinal infections.Hence,increased dietary MtC may support the anti-IL-10-induced intestinal immunity to Eimeria.Broilers(n=640)were arranged in a 2×2×2 factorial design with 2 levels of each of the 3 main factors:dietary standardized ileal digestible(SID)MtC levels(0.6%or 0.8%),dietary anti-IL-10 supplementation(with or without),and coccidiosis challenge(control or challenge).Briefly,the broilers were supplied with either 0.6%or 0.8%SID MtC,each with or without anti-IL-10(300 mg/kg),from d 10 to 21.On d 14,broilers from each diet were gavaged with either PBS or Eimeria.The resulting Eimeria infection induced fecal oocyst shedding and intestinal lesions.Broilers fed 0.8%SID MtC(main effects,P≤0.05)had decreased feed-to-gain ratio,increased duodenum and cecum luminal anti-Eimeria IgA titers,and decreased fecal oocyst counts,when compared to 0.6%SID MtC.The supplementation of anti-IL-10(main effects,P≤0.05)increased cecum luminal total IgA concentration and decreased cecum lesions.Interactions(P≤0.05)were detected for growth performance and cecum luminal IFN-γ.Briefly,the highest body weight gain and feed intake were reached in PBS-gavaged broilers fed 0.8%SID MtC with no anti-IL-10 and in Eimeria-challenged broilers fed 0.8%SID MtC with anti-IL-10.In Eimeria-infected broilers,anti-IL-10 increased intestinal luminal IFN-γ and body weight gain only at 0.8%SID MtC.Collectively,anti-IL-10 increased intestinal luminal IFN-γ levels,decreased cecum lesions and restored growth only when fed with adequate amounts of sulfur amino acids.Our findings underscore the importance of providing sufficient essential nutrients to support the anti-IL-10 induced immunity against coccidiosis. | Zhouzheng Ren Jiakun Yan Rose Whelan Xujie Liao Daniel E.Bütz Maria K.Arendt Mark E.Cook Xiaojun Yang Thomas D.Crenshaw | 2022 | Animal Nutrition2022，，3： | 0 |
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