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| 1 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Pulmonary Cryptococcosis: CT Findings in Immunocompetent Patients 显示文摘 | Rebecca ML Thomas EH Hassan FN | 2005 | Radiology2005，236，1： | 1 |
| 3 | The Wilson disease gene:spectrum of mutations and their conse- quences显示文摘 | Thomas GR Forbes JR Roberts Eh | 1995 | Nature Genet1995，9，2： | 1 |
| 4 | Comparative analyses of multi-species sequences from targeted genomic regions显示文摘 | Thomas JW Touchman JW Blakesley RW Bouffard GG Beckstrom-Sternberg SM Margulies EH Blanchette M Siepel AC Thomas PJ McDowell JC Maskeri B Hansen NF Schwartz MS Weber RJ Kent WJ Karolchik D Bruen TC Bevan R Cutler DJ Schwartz S Elnitski L Idol JR Prasad AB | | 0，，6950： | 1 |
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| 6 | A biomechanical study of intrapeduncular screw fixation in the lumbosacral spine显示文摘 | Zindrick MR Wiltse LL Widell EH Thomas JC Holland WR Field BT Spencer CW | 1986 | Clin Orthop Relat Res1986，20，3： | 1 |
| 7 | Electrodiagnostic of the carpal tunnel and related syndrome显示文摘 | Thomas JE Lambert EH Csez KA | 1967 | Arch Neurol1967，16，： | 1 |
| 8 | The effect of enzymatically degradable IPN coating on peri-implant bone formation and implant fixation 显示文摘 | James EH Thomas AB Amarjit SV | 2007 | J Biomed Mater Res2007，，81： | 1 |
| 9 | An outbreak of Legionnaires disease associated with a decorative water wall Fountain in a Hospital 显示文摘 | Thomas EH Richard TH James JK | 2012 | Infect Control Hosp Epidemiol2012，33，2： | 1 |
| 10 | Diabetic autoimmune markers in children and adolescents with type 2 diabetes显示文摘 | Hathout EH Thomas W El-Shahawy M | 2001 | Pediatrics2001，107，6： | 1 |
| 11 | Toll-like receptor cross-hyporesponsiveness is func-tional in interleukin-1-receptor-associated kinase-1(IRAK-1)-deficient macrophages:differential roleplayed by IRAK-1 in regulation of tumour necrosisfactor and interleukin-10 production 显示文摘 | Berglund M Thomas JA Hornquist EH | 2008 | Scand JImmunol2008，67，5： | 1 |
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