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| 1 | 人类免疫缺陷病毒感染者抑郁障碍、自杀风险和日常生活能力的研究显示文摘目的研究人类免疫缺陷病毒(H IV)感染者抑郁症和自杀观念的流行情况及其与日常生活能力改变的关联。方法对28例H IV阳性者及23例H IV阴性者,用复合性国际诊断用检查提纲中文版调查抑郁症的总发生率和自杀史,用贝克抑郁问卷(BD I)评估当前抑郁障碍及自杀风险的严重程度,用日常生活能力问卷(ADL)评估H IV感染对日常生活能力的影响。结果(1)H IV阳性组和H IV阴性组中分别有22例(79%)和1例(4%)符合抑郁症的诊断标准(P<0.001);H IV阳性组BD I总分[(22.4±12.7)分]高于H IV阴性组[(6.6±7.8)分;P<0.001]。(2)H IV阳性组和H IV阴性组中分别有18例(64%)和2例(9%)有过自杀观念。(3)H IV阳性组ADL总分[(17.1±5.2)分]高于H IV阴性组[(14.0±0.0)分;P<0.001]。(4)BD I与H IV状况的交互作用是有显著贡献(F=23.95,P<0.001)的自变量,抑郁障碍与H IV状况的相互作用是有意义(F=13.29,P=0.001)的预测因子。结论H IV感染的人群中抑郁症的发生率及自杀风险均较高,抑郁的严重程度和日常生活能力受损有显著相关性。 | 于欣 石川 金华 J.Hampton Atkinson Robert Heaton Thomas Marcotte Corinna Young Joseph Sadek 吴尊友 Igor Grant | 2006 | 中华精神科杂志2006，39，2： | 8 |
| 2 | Liver transplantation for acute intermittent porphyria:a viable treatment?显示文摘BACKGROUND:Acute intermittent porphyria (AIP) is the most common hepatic porphyria.Its clinical presentation includes severe disabling and life-threatening neurovisceral symptoms and acute psychiatric symptoms.These symptoms result from the overproduction and accumulation of porphyrin precursors,5-aminoleuvulinic acid (ALA) and porphobilinogen (PBG).The effect of medical treatment is transient and is not effective once irreversible neurological damage has occurred.Liver transplantation (LT) replaces hepatic enzymes and can restore normal excretion of ALA and PBG and prevent acute attacks.METHOD:Two cases of LT for AIP were identified retrospectively from a prospectively maintained LT database.RESULT:LT was successful with resolution of AIP in two patients who suffered from repeated acute attacks.CONCLUSION:LT can correct the underlying metabolic abnormality in AIP and improves quality of life significantly. | Faisal S Dar Koji Asai Ali Raza Haque Thomas Cherian Mohamed Rela Nigel Heaton | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 3 | Characterization of Near-Source Ground Motions with Earthquake Simulations显示文摘 | Aagaad Brad T Hall John F Heaton Thomas H | 2001 | Earthquake Spectra2001，17，2： | 1 |
| 4 | Miscanthus for Renewable Energy Generation: European Union Experience and Projections for Illinois显示文摘 | Emily A. Heaton Stephen P. Long Thomas B. Voigt Michael B. Jones John Clifton-Brown | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，4： | 1 |
| 5 | Effect of cholecystecto- my on bowel function: a prospective, controlled study 显示文摘 | Hearing SD Thomas LA Heaton KW | 1999 | Gut1999，45，6： | 1 |
| 6 | Miscanthus for Renewable Energy Generation Eu- ropean Union Experience and Projections for Illinois 显示文摘 | Emily A Heaton J C B Thomas B Voigt Michael B Jones | 2004 | Mitigation and Adaptation Strategies for Global Change2004，9，： | 1 |
| 7 | Effect of cholecyslectomy on bowel funetion: a prospective, eonlrolled study显示文摘 | Hearing SD Thomas LA Heaton KW el al | 1999 | Gut1999，45，6： | 1 |
| 8 | Cystic dystrophy in heterotopic pancreas:a rare indication for pancreaticoduodenectomy显示文摘BACKGROUND:Cystic dystrophy in heterotopic pancreas (CDHP)is a rare benign condition characterized by the presence of cysts in the wall of the digestive tract associated with inflammation and fibrosis,intermingled with heterotopic pancreatic tissue.Treatment options for CDHP are poorly defined. METHOD:We report a case of CDHP,and review the literature focusing on the diagnosis and management. RESULTS:CDHP is mainly encountered in men in the fifth decade of life in association with chronic pancreatitis secondary to alcohol ingestion.Alcohol and mechanical obstruction of heterotopic pancreatic ducts have been implicated in its pathogenesis.Clinical presentation is varied and current imaging provides the diagnosis. Treatment options include somatostatin analogue injections, endoscopic cyst fenestration and surgical resection (pancreaticoduodenectomy or gastrointestinal bypass). CONCLUSION:CDHP is rare and presents a diagnostic and therapeutic challenge.The long term efficacy and indications for different treatment options need to be refined. | Harun Thomas Paul Marriott Bernard Portmann Nigel Heaton Mohamed Rela | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 1 |
| 9 | Miscanthus for Renewable Energy Generation: European Union Experience and Projections for Illinois显示文摘 | Emily A. Heaton Stephen P. Long Thomas B. Voigt Michael B. Jones John Clifton-Brown | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，4： | 1 |
| 10 | 1047 Efficacy of an Investigational Recombinant Antigen Based Vaccine Against a CagA H. pylori Infectious Challenge in Healthy Volunteers显示文摘 | Peter Malfertheiner Michael Selgrad Thomas Wex Jan Bornschein Emanuela Palla Giuseppe Del Giudice David Graham Penny M. Heaton | 2012 | Gastroenterology2012，，5： | 1 |
| 11 | Characterization of near fource ground motions with earthquake simulations 显示文摘 | Brad T Aagaard John F Hall Thomas H Heaton | 2001 | Earthquake Spectra2001，17，2： | 1 |
| 12 | Late recurrence after surgery for cholangiocarcinoma:implications for follow-up?显示文摘BACKGROUND:Biliary tract cancer is uncommon,but has a high rate of early recurrence and a poor prognosis. There is only limited information on patients surviving more than 5 years after resection. METHODS:We report a patient who developed recurrence 8 years after resection of cholangiocarcinoma.Descriptions of late recurrence after excision of cholangiocarcinoma are reviewed. RESULTS:Few long-term survivors with biliary tract cancer have been reported.The survivors tend to have well differentiated or papillary tumors.The present case had no recurrence for 8 years despite poor prognostic factors including poor differentiation,invasion through the muscle wall and perineural invasion.It has been suggested that tumor cells left after the first operation grow and present as late recurrence.There is a need to differentiate a new primary and field change from recurrence of the previous tumor. CONCLUSIONS:Long-term follow-up after resection of cholangiocarcinoma is needed because late recurrence after 5 years occurs.The mortality rate between 5 and 10 years after resection of cholangiocarcinoma ranges from 6%to 43%in different series.Early detection of local recurrence may give an opportunity for further surgical resection. | Harun Thomas Nigel David Heaton | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 0 |
| 13 | 洛杉矶盆地密集地震台网显示文摘引言位于加州洛杉矶的密集强震区域(社区)地震台网(Community Seismic Network,CSN),目前由500个传感器组成(图1)。地震台网的传感器是低成本微机电(low-cost microelectromechanical,MEM)加速度计传感器,最大可以记录±2g的加速度。台网最初的主要产品是在大地震发生后几秒钟测量地面震动(图2)。 | Robert W.Clayton Thomas Heaton Monica Kohler Mani Chandy Richard Guy Julian Bunn 陈会忠(译) 张晁军(校) | 2019 | 国际地震动态2019，0，12： | 0 |
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