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| 1 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 2 | Experience with more than 500 minimally invasive hepatic procedures显示文摘 | Buell JF Thomas MT Rudich S | 2008 | Ann Surg2008，248，3： | 1 |
| 3 | lschemic Colitis显示文摘 | Marston A Pheils MT Thomas ML | 1996 | Gut1996，7，： | 1 |
| 4 | TLR signaling at the intestinal epithelial interface显示文摘 | Abreu MT Thomas LS Arnold ET | 2003 | J Endotoxin Res2003，9，： | 1 |
| 5 | TLR4 and MD-2 expression is regulated by immtme-mediated signals in human intestinal epithelial cells显示文摘 | Abreu MT Arnold ET Thomas LS | 2002 | J Biol Chem2002，277，20： | 1 |
| 6 | Ischemic colitis显示文摘 | MarstonA Pheils MT Thomas ML | 1996 | Gut1996，7，： | 1 |
| 7 | Ischaemic colitis显示文摘 | Marston A Pheils MT Thomas ML | | 0，，： | 1 |
| 8 | Parathyroid responsiveness tohypocalcemic and hypercalcemic stimuli in adult growth hormone defi-ciency after growth hormone replacement显示文摘 | Ahmad MA Hopkins MT Thomas J | 2004 | AM J Physiol Endocrinol Metab2004，286，： | 1 |
| 9 | Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation,osteoclast recruitment,and bone turnover显示文摘 | Cowan CM Aalami OO Shi YY Chou YF Mari C Thomas R Quarto N Nacamuli RP Contag CH Wu B Longaker MT | | 0，，： | 1 |
| 10 | Post-GWAS func- tional characterization of susceptibility variants for chronic lymphocytic leukemia 显示文摘 | Sill FC Thomas R Smith MT | 2012 | PLoS One2012，7，29： | 1 |
| 11 | Experience with more than 500 minimally invasive hepatic procedures显示文摘 | Buell JF Thomas MT Rudich S | 2008 | Arm Surg2008，248，： | 1 |
| 12 | Ischemic colitis显示文摘 | Marston A Pheils MT Thomas ML | 1996 | Gut1996，7，： | 1 |
| 13 | Efficacy of Noninvasive positive pressure ventilation to treats severe acute respiratory and acute respiratory failure显示文摘 | Thomas MT Cheung Lorette YC yam | 2004 | Chest2004，126，： | 1 |
| 14 | Mutations in the homeobox gene HESX1/Hesxl associated with septo-optic dysplasia in human and mouse显示文摘 | Dattani MT Martinez-Barbera JP Thomas PQ | 1998 | Nat Genet1998，19，2： | 1 |
| 15 | TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells显示文摘 | Abreu MT Arnold ET Thomas LS | 2002 | The Journal of Biological Chemistry2002，277，20： | 1 |
| 16 | microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity显示文摘 | Juarez MT Kui JS Thomas J | 2004 | Nature2004，428，6978： | 1 |
| 17 | Ischemic colitis显示文摘 | Marston A Pheils MT Thomas ML | 1966 | Gut1966，7，1： | 1 |
| 18 | Ischemic colitis显示文摘 | Marston A Pheils MT Thomas ML | 1996 | Gut1996，7，1： | 1 |
| 19 | TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells显示文摘 | Abreu MT AmoId ET Thomas LS | 2002 | J Biol Chem2002，277，20： | 1 |
| 20 | Ischemic colitis显示文摘 | Marston A Pheits MT Thomas ML | 1996 | Cut1996，7，1： | 1 |
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