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| 1 | Electrospun poly(vinylidene fluoride-trifluoroethylene)/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation显示文摘响应机械紧张产生电的信号的压电的材料能在设计刺激房间增长的织物被使用。Poly (vinylidene fluoride-trifluoroethylene )(P (VDF-TrFE )) ,压电的聚合物,广泛地在 biomaterial 应用被使用。我们假设了进 P (VDF-TrFE ) 矩阵的 nanoparticles 能支持的锌氧化物(ZnO ) 的那加入房间的粘附,移植,和增长,以及血容器形成(angiogenesis ) 。在这研究,我们制作了并且包括地描绘了新奇 electrospun P (VDF-TrFE )/ZnO nanocomposite 织物设计支架。我们由扫描电子显微镜学分析了聚合矩阵的词法特征,并且利用了红外线的光谱学, X 光检查衍射,和检验的微分扫描热量测定由于 nanoparticles 的增加在共聚物的水晶的阶段改变的 Fourier 变换。我们不检测了,显示 P (VDF-TrFE )/ZnO nanocomposite 脚手架对设计应用的织物合适或关于在 vitro, biocompatibility,和 cytotoxicity 的血相容性的 biomaterials 的最小的不利效果。有趣地,人的间充质的干细胞(hMSCs ) 和在 nanocomposite 脚手架上有教养的人的脐的静脉 endothelial 房间与在织物文化盘子或整洁的 P (VDF-TrFE ) 上有教养的房间相比展出了更高的房间生存能力,粘附,和增长脚手架。植入进老鼠与或没有 hMSCs 的 Nanocomposite 脚手架没得到免疫学的回答,由宏观的分析和组织学估计了。重要地, nanocomposite 脚手架支持了 angiogenesis,它在脚手架被增加与 hMSCs 预先播种。总的来说,我们的结果在织物工程为使用加亮这些新奇 P (VDF-TrFE )/ZnO nanocomposites 的潜力,由于他们支持房间粘附和 angiogenesis 的 biocompatibility 和能力。 | Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu Didier Rouxel | 2017 | Nano Research2017，10，10： | 8 |
| 2 | Conf irmation of endotracheal tube placement using disposable f iberoptic bronchoscopy in the emergent setting显示文摘BACKGROUND:Patients intubated in the prehospital setting require quick and definitive confirmation of endotracheal (ET) tube placement upon arrival to the emergency department (ED).Direct and adjunct strategies exist,but each has limitations and there is no definitive gold standard.The utility of bronchoscopy in ED intubation has been studied,but scant literature exists on its use for ET tube confirmation.This study aims to assess effectiveness,ease and speed with which ET tube placement can be confirmed with disposable fiberoptic bronchoscopy.METHODS:Emergency medicine residents recruited from a 3-year urban residency program received 5 minutes of active learning on a simulation mannequin using a disposable,flexible Ambu aScope interfaced with a monitor.With residents blinded,the researcher randomly placed the ET tube in the trachea,esophagus or right mainstem.Residents identified ET tube position by threading the bronchoscope through the tube and viewing distal anatomy.Each resident underwent 4 trials.Accuracy,speed and perceptions of difficulty were measured.RESULTS:Residents accurately identified the location of the ET tube in 88 out of 92 trials (95.7%).The median time-to-guess was 7.0 seconds,IQR (5.0-10.0).Average perceived difficulty was 1.6 on a scale from 1-5 (1 being very easy and 5 being very difficult).No tubes were damaged or dislodged.CONCLUSION:While simulation cannot completely replicate the live experience,fiberoptic bronchoscopy appears to be a quick and accurate method for ET tube confirmation.Further studies directly comparing this novel approach to established practices on actual patients are warranted. | Avir Mitra Asaf Gave Kelsey Coolahan Thomas Nguyen | 2019 | World Journal of Emergency Medicine2019，10，4： | 5 |
| 3 | One-Year Outcomes of the DA VINCI Study of VEGF Trap-Eye in Eyes with Diabetic Macular Edema显示文摘 | Diana V. Do Quan Dong Nguyen David Boyer Ursula Schmidt-Erfurth David M. Brown Robert Vitti Alyson J. Berliner Bo Gao Oliver Zeitz Rene Ruckert Thomas Schmelter Rupert Sandbrink Jeff S. Heier | 2012 | Ophthalmology2012，，8： | 4 |
| 4 | Gastric per-oral endoscopic myotomy: Current status and future directions显示文摘Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field. | Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke | 2019 | World Journal of Gastroenterology2019，25，21： | 3 |
| 5 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 6 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 7 | A New Species of Rhacophorus(Amphibia:Anura:Rhacophoridae)from Vietnam显示文摘We describe a new species of Rhacophorus based on two adult specimens collected from Hoa Binh Province, northern Vietnam. Rhacophorus hoabinhensis sp. nov. is distinguishable from its congeners on the basis of a combination of the following morphological characters: size small(SVL 31.1–32.5 mm in males); head slightly longer than wide; vomerine teeth absent; snout short(SNL/SVL 0.16); dorsal skin smooth; forearm and tarsus with dermal fringes; dermal appendage at vent present; webbing formula on fingers Ⅰ12/3-12/3 Ⅱ1-2 Ⅲ1-1 Ⅳ and on toes Ⅰ3/4-1 Ⅱ1/2-1Ⅲ1/2-1 Ⅳ1-1/2Ⅳ; dorsal surface grey yellow with brown spots; lower jaw region dark grey, throat, chest and belly cream; anterior and posterior thighs, as well as ventral surface of tibia orange. The interspecific uncorrected genetic distances(16 S rRNA gene) between the new species from Hoa Binh and other analyzed congeners varied from 9.8% to 17.4%. In the phylogenetic analyses, the new species revealed to be a representative of Rhacophorus and was nested within the R. hoanglienensis-orlovi species group. | Tao Thien NGUYEN Cuong The PHAM Truong Quang NGUYEN Hoa Thi NINH Thomas ZIEGLER | 2017 | Asian Herpetological Research2017，18，4： | 2 |
| 8 | Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy显示文摘AIM: To characterize the effects of iodinated contrast material(ICM) on magnetic resonance imaging(MRI) comparing different sequences and magnetic fields, with emphasis to similarities/differences with well-known signal characteristics of hemorrhage in the brain. METHODS: Aliquots of iopamidol and iodixanol mixed with normal saline were scanned at 1.5T and 3T. Signal intensity(SI) was measured using similar spin-echo(SE)-T1, SE-T2, gradient-echo(GRE) and fluid-attenuationinversion-recovery(FLAIR) sequences at both magnets. Contrast to noise ratio(CNR)(SI contrast-SI saline/SD noise) for each aliquot were calculated and Kruskall-wallis test and graphic analysis was used to compare different pulse sequences and ICMs. RESULTS: Both ICM showed increased SI on SE-T1 and decreased SI on SE-T2, GRE and FLAIR at both 1.5T and 3T, as the concentration was increased. By CNR measurements, SE-T2 had the greatest conspicuity at 3T with undiluted iopamidol(92.6 ± 0.3, P < 0.00) followed by iodixanol(77.5 ± 0.9, P < 0.00) as compared with other sequences(CNR range: 15-40). While SE-T2 had greatest conspicuity at 1.5T with iopamidol(49.3 ± 1, P < 0.01), SE-T1 showed similar or slightly better conspicuity(20.8 ± 4) than SE-T2 with iodixanol(23 ± 1.7). In all cases, hypo-intensity on GRE was less conspicuous than on SE-T2.CONCLUSION: Iodixanol and iopamidol shorten T1 and T2 relaxation times at both 1.5T and 3T. Hypo-intensity due to shortened T2 relaxation time is significantly more conspicuous than signal changes on T1-WI, FLAIR or GRE. Variations in signal conspicuity according to pulse sequence and to type of ICM are exaggerated at 3T. We postulate T2 hypointensity with less GRE conspicuity differentiates ICM from hemorrhage; given the wellknown GRE hypointensity of hemorrhage. Described signal changes may be relevant in the setting of recent intra-arterial or intravenous ICM administration in translational research and/or human stroke therapy. | Humberto Morales Lisa Lemen Ranasinghage Samaratunga Peter Nguyen Thomas Tomsick | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 9 | Two-Year Outcomes of the Ranibizumab for Edema of the mAcula in Diabetes (READ-2) Study显示文摘 | Quan Dong Nguyen Syed Mahmood Shah Afsheen A. Khwaja Roomasa Channa Elham Hatef Diana V. Do David Boyer Jeffery S. Heier Prema Abraham Allen B. Thach Eugene S. Lit Bradley S. Foster Erik Kruger Pravin Dugel Thomas Chang Arup Das Thomas A. Ciulla John S. P | 2010 | Ophthalmology2010，，11： | 2 |
| 10 | Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Shabana F. Pasha M. Edwyn Harrison Ananya Das Cuong C. Nguyen Hugo E. Vargas Vijayan Balan Thomas J. Byrne David D. Douglas David C. Mulligan | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 11 | T - cell tolerance or function is determined by combinatorial costimulatory signals显示文摘 | Nurieva R Thomas S Nguyen T | 2006 | EMBO J2006，25，11： | 1 |
| 12 | Ocular surface reconstruction : re- cent advances and future outlook 显示文摘 | Yiu SC Thomas PB Nguyen P | 2007 | Curr Opin Ophthalmol2007，18，6： | 1 |
| 13 | Sieve algorithms for the shortest vector problem are practical显示文摘 | Phong Q. Nguyen Thomas Vidick | 2008 | Journal of Mathematical Cryptology2008，，2： | 1 |
| 14 | Drying conditions in Switzerland-indication from a 35-year Landsat time-series analysis of vegetation water content estimates to support SDGs显示文摘Exacerbated by climate change,Europe has experienced series of hot and dry summer since the beginning of the 21st century.The importance of land conditions became an international concern with a dedicated sustainable development goal(SDG),the SDG 15.It calls for developing and finding innovative solu-tions to follow and evaluate impacts of changing land condi-tions induced by various driving forces.In Switzerland,drought risk will significantly increase in the coming decades with severe consequences on agriculture,energy production and vegeta-tion.In this paper,we used a 35-year satellite-derived annual and seasonal times-series of normalized difference water index(NDWI)to follow vegetation water content evolution at different spatial and temporal scales across Switzerland and related them to temperature and precipitation to investigate possible responses of changing climatic conditions.Results indicate that there is a small and slow drying tendency at the country scale with a NDWI mean decreasing slope of−0.22%/year for the 23%significant pixels across Switzerland.This tendency is mostly visible below 2000 m above sea level(m.a.s.l.)and in all biogeographical regions.The Southern Alps regions appear to be more responsive to changing drying conditions with a significant and slight negative NDWI trend(−0.39%/year)over the last 35 years.Moreover,NDWI values are mostly a func-tion of temperature at elevations below the tree line rather than precipitation.Findings suggest that multi-annual and seasonal NDWI can be a valuable indicator to monitor vegetation water content at different scales,but other components such as land cover type and evapotranspiration should be considered to better characterize NDWI variability.Satellite Earth Observations data can provide valuable complementary obser-vations for national statistics on the ecological state of vegeta-tion to support SDG 15 to monitor land affected by drying conditions. | Charlotte Poussin Alexandrine Massot Christian Ginzler Dominique Weber Bruno Chatenoux Pierre Lacroix Thomas Piller Liliane Nguyen Gregory Giuliani | 2021 | Big Earth Data2021，5，4： | 1 |
| 15 | Predictive Value of Electrophoretically Detected Lipoprotein(a) for Coronary Heart Disease and Cerebrovascular Disease in a Community-Based Cohort of 9936 Men and Women显示文摘 | Tu T. Nguyen Ralph D. Ellefson David O. Hodge Kent R. Bailey Thomas E. Kottke Haitham S. Abu-Lebdeh | 1997 | Circulation1997，，： | 1 |
| 16 | Proteolytic cleavage of Ii to p25显示文摘 | Thomas LJ Nguyen QV Elliott WL | 1988 | J Immunol1988，140，8： | 1 |
| 17 | Minimally Invasive Liver Resection for Metastatic Colorectal Cancer: A Multi-Institutional, International Report of Safety, Feasibility, and Early Outcomes显示文摘 | Kevin Tri Nguyen Alexis Laurent Ibrahim Dagher David A. Geller Jennifer Steel Mark T. Thomas Michael Marvin Kadiyala V. Ravindra Alejandro Mejia Panagiotis Lainas Dominique Franco Daniel Cherqui Joseph F. Buell T Clark Gamblin | 2009 | Annals of Surgery2009，，5： | 1 |
| 18 | Effects of pre -, peri - , anf postmyocardial infaraction treatment with losartan in rats: effect of does on survival, ventricular arrhythmias,function, and remodeling 显示文摘 | Ali Pourdjabbar Thomas G Parker Quang Trinh Nguyen | 2005 | Am J Physiol Heart Circ Physical2005，288，： | 1 |
| 19 | Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Shabana F. Pasha M. Edwyn Harrison Ananya Das Cuong C. Nguyen Hugo E. Vargas Vijayan Balan Thomas J. Byrne David D. Douglas David C. Mulligan | 2007 | Gastrointestinal Endoscopy2007，，1： | 1 |
| 20 | Pulmonary and Mediastinal Glomus Tumors: Report of Five Cases Including a Pulmonary Glomangiosarcoma: A Clinicopathologic Study With Literature Review显示文摘 | Erich M. Gaertner David M. Steinberg Monica Huber Tomayoshi Hayashi Nobuo Tsuda Frederic B. Askin Stephen W. Bell Ba Nguyen Thomas V. Colby Stephen L. Nishimura Markku Miettinen William D. Travis | 2000 | The American Journal of Surgical Pathology2000，，8： | 1 |
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