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| 1 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Innervation of annulus fibrosis in low back pain显示文摘 | COPPES M H MARANI E THOMEER R T | 1990 | Lancet1990，336，： | 1 |
| 3 | Innervation of 'painful' lumbar discs显示文摘 | Coppes MH Marani E Thomeer RT | 1997 | Spine1997，22，20： | 1 |
| 4 | Introduction of a pore geometrical factor de- fined by the capillary pressure curve显示文摘 | Thomeer J H M | 1960 | Journal of Petroleum Technology1960，12，3： | 1 |
| 5 | Innervation of 'painful' lumbar discs显示文摘 | COPPES M H MARANI E THOMEER R T | 1997 | Spine1997，22，： | 1 |
| 6 | Patient acceptance for CT colonography: What is the real issue? 显示文摘 | Thomeer M Bielen D Vanbeckevoort D | 2002 | Eur Radiol2002，12，6： | 1 |
| 7 | Ear and hearing problems in relation to karyotype in children with Turner syndrome显示文摘 | Verver E J Freriks K Thomeer H G | 2011 | Hear Res2011，275，12： | 1 |
| 8 | RCT of a Manualized Social Treatment for High - Functioning Autism Spectrum Disorders 显示文摘 | Lopata Thomeer Volker Toomey Nida Lee Smerbeck and Rodgers | 2010 | J AU- TISM DEV DISORD2010，，40： | 1 |
| 9 | The value of temporary external lumbar CSF drainage in prediciting the outcome of shunting on normal pressure hy- drocephalus显示文摘 | Walehenbach R Geiger E Thomeer RT | 2002 | J Neurol Neurosurg Psychiatry2002，72，： | 1 |
| 10 | The value of tempo-rary external lumbar CSF drainage in predicting the outcome of shun- ting on normal pressure hydrocephalus 显示文摘 | Walehenbaeh R Geiger E Thomeer RT | 2002 | J Neurol Neurosurg Psy- chiatry2002，72，4： | 1 |
| 11 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial显示文摘 | Talmadge E King Carlo Albera Williamson Z Bradford Ulrich Costabel Phil Hormel Lisa Lancaster Paul W Noble Steven A Sahn Javier Szwarcberg Michiel Thomeer Dominique Valeyre Roland M du Bois | 2009 | The Lancet . 2009 (9685)2009，，： | 1 |
| 12 | Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification显示文摘 | van Aalten SM Thomeer MG Terkivatan T | 2011 | Radiology2011，261，1： | 1 |
| 13 | Innervation of painful in lumbar discs 显示文摘 | Coppes MH Marani E Thomeer RT | 1997 | Spine1997，22，20： | 1 |
| 14 | Introduction of a pore geometrical factor defined by the capillary pressure curve 显示文摘 | THOMEER J H | 1960 | Trans AIME1960，219，： | 1 |
| 15 | The value of temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus 显示文摘 | Walchenbach R Geiger E Thomeer RT | 2002 | J Neurol Neurosurg Psychiatry2002，72，4： | 1 |
| 16 | Neoadjuvant chemotherapy followed by radiotherapy and concurrent hypertbermia in patients with advanced-stage cervical cancer: a retrospective study 显示文摘 | Heijkoop ST Franckena M Thomeer MG et d | 2012 | Int J Hyperthe- rmia2012，28，6： | 1 |
| 17 | The value of temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus显示文摘 | Walchenbach R Geiger E Thomeer R | 2002 | J Neurol Neurosurg Psychiaty2002，72，4： | 1 |
| 18 | The value of temporary external lumbar CSF drainage in predicting the outcome of shuning on normal pressure hydrocephalus显示文摘 | Walchenbach R Geiger E Thomeer R T | 2002 | J Nenrol Neurosurg Psychiatry2002，72，4： | 1 |
| 19 | The value of 'temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus 显示文摘 | Walchenbach R Geiger E Thomeer RT | 2002 | J Neurol Neurosurg Psychiatry2002，72，4： | 1 |
| 20 | Clinical use of biomarkers of survival in pulmonary fibrosis 显示文摘 | Thomeer M Grutters JC Wuyts WA | 2010 | Respir Res2010，11，： | 1 |
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