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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis显示文摘 | Julian J. Lum Daniel E. Bauer Mei Kong Marian H. Harris Chi Li Tullia Lindsten Craig B. Thompson | 2005 | Cell2005，，2： | 3 |
| 3 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 3 |
| 4 | National Park vegetation mapping using multitemporal Landsat 7 data and a decision tree classifier显示文摘 | Eric C. Brown de Colstoun Michael H. Story Craig Thompson Kathy Commisso Timothy G. Smith James R. Irons | 2003 | Remote Sensing of Environment2003，，3： | 2 |
| 5 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 6 | Antioxidant activities, phenolic and β-carotene contents of sweet potato genotypes with varying flesh colours显示文摘 | Choong C. Teow Van-Den Truong Roger F. McFeeters Roger L. Thompson Kenneth V. Pecota G. Craig Yencho | 2006 | Food Chemistry2006，，3： | 2 |
| 7 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 8 | Treatment of deepcarious lesions by complete excavation or partial removal : a criti-cal review显示文摘 | Thompson V Craig RG Curro FA | 2008 | J Am Dent Assoc2008，139，6： | 1 |
| 9 | A paternally inherited duplication in the Prader-Willi/Angelman syndrome critical region:a case and family study显示文摘 | Veltman MW Thompson RJ Craig EE | 2005 | J Autism Dev Disord2005，35，： | 1 |
| 10 | Gonadotropin and intra -ovarian signals regulating follicle development and atresia: the delicate balance between life and death 显示文摘 | Craig J Orisaka M Wang H Orisaka S Thompson W Zhu C Kotsuji F Tsang BK | 2007 | Front Biosci2007，12，： | 1 |
| 11 | Socioeconomic status and preterm birth: New Zealand trends 1980 to 1999 显示文摘 | Craig ED Thompson JM Mitchell EA | 2002 | Arch Dis Child Fetal Neonatal Ed2002，，： | 1 |
| 12 | ATP citrate lyase inhibition can suppress tumor cell growth显示文摘 | Georgia Hatzivassiliou Fangping Zhao Daniel E. Bauer Charalambos Andreadis Anthony N. Shaw Dashyant Dhanak Sunil R. Hingorani David A. Tuveson Craig B. Thompson | 2005 | Cancer Cell2005，，4： | 1 |
| 13 | Long-term prognosis after recovery from myocardial infarction: a nine year follow-up of the Perth Coronary Register显示文摘 | Craig A. Martin Peter L. Thompson Bruce K. Armstrong Michael S. T. Hobbs Nicholas de Klerk | 1983 | Circulation1983，，5： | 1 |
| 14 | Preparation and characterization of metal oxide/poly-imide nanocomposites显示文摘 | THOMPSON Craig M HERRING Helen M THOMAS S | 2003 | Composites Science and Technology2003，，63： | 1 |
| 15 | Platelet size does not correlate with platelet age 显示文摘 | Craig B Thompson Donald G Love Patrick G Quinn | 1993 | Blood1993，62，： | 1 |
| 16 | Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study显示文摘Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS.Multivariable logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with non-smokers.In univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard criteria.Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS.Trial registration number NCT01422616. | Lingli Sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 17 | Kinetics and proposed mechanism of the reaction of an immunoinhibition,particle-enhanced immunoassay显示文摘 | Thompson JC Craig AR Davey CL | 1997 | Clin Chem Dec1997，43，11： | 1 |
| 18 | Ultrasonography of the ro- tator cuff: surgical correlation 显示文摘 | Crass JR Craig EV Thompson RC | 1984 | Journal of clinical ultrasound1984，12，8： | 1 |
| 19 | Autophagy in cellular metabolism and cancer显示文摘 | Jiang Xuejun Overholtzer Michael Thompson Craig B | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 20 | Apoptosis in the pathogenesis and treatment of disease 显示文摘 | Craig B Thompson | 2001 | Science2001，267，： | 1 |
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