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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Emeishan Basalt Ar–Ar overprint ages define several tectonic events that affected the western Yangtze platform in the Mesozoic and Cenozoic ☆显示文摘 | Jason R. Ali Ching-hua Lo Gary M. Thompson Xieyan Song | 2003 | Journal of Asian Earth Sciences2003，，2： | 1 |
| 3 | Islet cell carcinoma of the pancreas显示文摘 | Lo CY Van Heerden JA Thompson GB | 1996 | World J Surg1996，20，7： | 1 |
| 4 | A comparison of two forms of intensive speech treatment for Parkinson disease显示文摘 | Ramig LO Countryman S Thompson L | 1995 | Speech Hear Res1995，38，： | 1 |
| 5 | Organ-specific regula- tion of pro-inflammatory molecules in heart, lung, and kidney followi- ng brain death 显示文摘 | Skrabal CA Thompson LO Potapov EV | 2005 | J Surg Res2005，123，1： | 1 |
| 6 | Intensive speech treatment for patients with Parkinson disease: Short and long-term comparison of two techniques显示文摘 | Ramig LO Countryman S Thompson L | 1996 | Neurology1996，47，： | 1 |
| 7 | Organ-specific regulation of pro-inflammatory molecules in heart,lung,and kidney following brain death显示文摘 | Skrabal CA Thompson LO Potapov EV | 2005 | J Surg Res2005，123，1： | 1 |
| 8 | Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients显示文摘 | Skrabal CA Loebe M | 2005 | J Surg Res2005，123，1： | 1 |
| 9 | Half-life of intracameral gentamicin after phacoemulsification 显示文摘 | Lehmann O J Thompson JP White LO | 1997 | J Cataract Refract Surg1997，23，： | 1 |
| 10 | Parathyroid carcinoma 显示文摘 | Thompson LO | 2009 | Ear Nose Throat J2009，88，1： | 1 |
| 11 | Comparison of two forms of intensive speech treatment for Parkinson dis- ease显示文摘 | Ramig LO Countryman S Thompson LL | 1995 | J Speech Hear Res1995，38，6： | 1 |
| 12 | Islet cell carcinoma of the pancreas显示文摘 | Lo CY van Heerden JA Thompson GB | 1996 | World J Surg1996，20，7： | 1 |
| 13 | Interaction between isolated human myocardial mast cells and cuhured broblasts显示文摘 | Skrahel CA Thompson LO Southerd RE | 2004 | J Surg Res2004，118，1： | 1 |
| 14 | Organ-specific regulation of pro-inflammatory molecules in heart,lung,and kidney following brain death显示文摘 | Skrabal CA Thompson LO Potapov EV | 2005 | J Surg Res2005，123，1： | 1 |
| 15 | Phylogenetic evidence for a single, ancestral origin of a 'true' worker caste in termites显示文摘 | Thompson G J Kitade O Lo N | 2000 | Journal of Evolutionary Biology2000，13，： | 1 |
| 16 | Emeishan basalt Ar - Ar overprint ages define several tectonic events that affected the western Yangtze platform in the Mesozoic and Cenozoic 显示文摘 | Ali J R Lo C H Thompson G M | 2004 | Journal of Asian Earth Sciences2004，23，2： | 1 |
| 17 | Phylogenetic evidence for a single, ancestral origin of a 'tree' worker caste in termites显示文摘 | Thompson G J Kitade O Lo N | 2000 | J Evol Biol2000，13，6： | 1 |
| 18 | Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients显示文摘 | Thompson LO Skrabal CA Loebe M | 2005 | J Surg Res2005，123，1： | 1 |
| 19 | Interaction Between Isolated Human Myocardial Mast Cells and Cultured Fibroblasts显示文摘 | Skrabal CA Thompson LO Southard RE | 2004 | J Surg Res2004，118，1： | 1 |
| 20 | Islet cell carcinoma of the pancreas显示文摘 | LO CY van Heerden JA Thompson GB | 1996 | World J Surg Sep1996，20，7： | 1 |
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