|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Esterification of ophthalmic anhydride with 2-ethylhexanol by solid superacidic catalysts 显示文摘 | Thorat T S Yadav V M Yadav G D | 1992 | Applied Catalysis A : General1992，90，2： | 1 |
| 3 | Esterification of phthalic anhydride with 2-ethylhexnol by solid superacidic catalysts 显示文摘 | THORAT T S YADAV V M YADAV G D | 1992 | Applied Catalysis A: General1992，90，2： | 1 |
| 4 | Optimization of spray drying of ginger extraet 显示文摘 | Jangam Sachin V Thorat Bhaskar N | 2010 | Drying Technology2010，28，12： | 1 |
| 5 | Esterification of phthalic anhydride with 2-ethylhexanol by solid superacidic catalysts 显示文摘 | THORAT T S YADAV V M YADAV G D | 1992 | Appl Catal A1992，90，2： | 1 |
| 6 | Extraction and purification of phosphatidylcholine from soybean lecithin显示文摘 | Vilas V Patil Revanappa V Galge Bhaskar N Thorat | 2010 | Separation and Purification Technology2010，75，2： | 1 |
| 7 | Effect of sparger design and height to diameter ratio on fractional gas hold-up in bubble columns 显示文摘 | Thorat B N Shevade A V Joshi J B | 1998 | Chemical Engineering Research and Design1998，76，7： | 1 |
| 8 | Potential of Chromolaena odorata for phytoremediation of 137 C$ from solution and low level nuclearwaste 显示文摘 | Singh S Thorat V Kaushik CP | 2009 | Journal of Hazardous Materials2009，162，23： | 1 |
| 9 | Phytoremediation of radiostrontium (^90Sr) and radiocesium (^137Cs) using giant milky weed(Calotropis gigantean R Br) plants 显示文摘 | EAPEN S SINGH S THORAT V | 2006 | Chemosphere2006，，65： | 1 |
| 10 | Phytoremediation ^137Cesium and ^90strontium from solutions and low-level nuclear waste by ve-tiveria zizanoides显示文摘 | SINGH S EAPEN S THORAT V | 2008 | Ecotoxicology and Environmental Safety2008，69，2： | 1 |
| 11 | Potential of chromolae-na odorata for phytoremediation of'37Cs from solution and low level nu-clear waste显示文摘 | SINGH S THORAT V KAUSHIK C P | 2009 | Journal of Hazardous Materials2009，162，23： | 1 |
| 12 | Physical properties of aliphatic polycarbonates made from CO2 and epoxides显示文摘 | Thorat S D Phillips P J Semenov V Gakh A | 2003 | J Appl Polym Sci2003，89，5： | 1 |
| 13 | Physical properties of aliphatic polycarbonates made from CO2 and epoxides显示文摘 | THORAT S D PHILLIPS P J SEMENOV V | 2003 | J Appl Polym Sci2003，89，5： | 1 |
| 14 | Esterification of Phthalic Anhydride with 2-ethylhexanol by Solid Superacidic Catalysts 显示文摘 | Thorat T S Yadav V M Yadav G D | 1992 | Appl CatalA:General1992，90，2： | 1 |
| 15 | Pressure drop studies in bubble columns 显示文摘 | Thorat B N Kataria K Kulkarni A V | 2001 | Industrial and Engineering Chemistry Research2001，40，16： | 1 |
| 16 | Phytoremediation of 137cesium and 90strontium from solutions and low-level nuclear waste by Vetiveria zizanoides显示文摘 | Singh S Eapen S Thorat V | 2008 | Ecotoxicology and Environmental Safety2008，69，2： | 1 |
| 17 | Esterification of phthalic anhydride with 2-ethylhexanol by solid superacidic catalysts显示文摘 | THORAT T S YADAV V M YADAV G D | 1992 | Applied Catalysis A: General1992，90，2： | 1 |
| 18 | Physical properties of aliphatic polycarbonates made from CO2 and epoxides显示文摘 | THORAT S D PHILLIPS P J SEMENOV V | 2003 | J Appl Polym Sci2003，89，： | 1 |
| 19 | Structured superparamagnetic nanoparticles {or high performance mediator of magnet ic fluid hyperthermia: Synthesis, colloidal stability and biocompatibility evaluation显示文摘 | Thorat N D Otari S V Bohara R A | 2014 | Mat Sci Eng C2014，42，： | 1 |
| 20 | Performance of carbon-fibar-containing LiFePO4 cathodes for highpower applications显示文摘 | Indrajeet V Thorat Vipul Mathur John N Harb | 2006 | Journal of Power Sources2006，，162： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员