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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Differ- ential and genetically separable associations of leptin with obesity-related traits 显示文摘 | Thorbum A W Holdsworth A Proietto J | 2000 | International Journal of Obesity2000，24，6： | 1 |
| 3 | Autophagy in cancer, good, bad, or both?显示文摘 | Hippert MM O'Toole PS Thorbum A | 2006 | Cancer Res2006，66，19： | 1 |
| 4 | Autophagy and metastasis: another double-edged sword 显示文摘 | Kenific CM Thorbum A Debnath J | 2010 | Curr Opin Cell Biol2010，22，2： | 1 |
| 5 | Risk factors for cctop ic pregnancyin ass isted reproduction 显示文摘 | StrandeU A Thorbum J Hamberger L | 1999 | Fcrtil Steril1999，71，： | 1 |
| 6 | Risk factors for ectopic pregnancy in assisted reproduction显示文摘 | Strandell A Thorbum J Hamberger L | 1999 | Fertil Steril1999，71，： | 1 |
| 7 | Changes in soil carbon sequestration, fractionation and soil fertility in response to sugarcane residue retention are site-specific显示文摘 | Thorbum P J Meier E A Collins K | 2012 | Soil and Tillage Research2012，120，： | 1 |
| 8 | The identification anti determination of cationic dyes in dye liquors for acrylic fibre and extracted from finished products 显示文摘 | Thorbum Burns D McGuigan A A | 1991 | Fresenius'' Journal of Analytical Chemistry1991，，340： | 1 |
| 9 | Mitogen-activated protein kinase mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy显示文摘 | Thorbum WJ Frost JA Thorbum A | 1994 | J Cell Biol1994，126，6： | 1 |
| 10 | Food processing and the glyccmic index显示文摘 | BRAND J C NICHOLSON P L THORBUM A W | 1985 | American Journal of Clinical Nutrition1985，42，： | 1 |
| 11 | Risk factois for ectopic preg-nancy in assisted reproduction 显示文摘 | Strandell A Thorbum J Hamberger L | 1999 | Fertil Steril1999，71，2： | 1 |
| 12 | TRAIL receptor - targeted therapeutics :resistance mechanisms and strategies to avoid them 显示文摘 | Thorbum A Behbakht K Ford H | 2008 | Drug Resist Updat2008，11，12： | 1 |
| 13 | Risk factors for ectopic pregnancy in assisted reproduction显示文摘 | St randell A Thorbum J Hamberger L | 2000 | Fertil Steril2000，71，2： | 1 |
| 14 | Autophagy and metastasis: an- other double edged sword 显示文摘 | Kenific CM Thorbum A Debnath J | 2010 | Curt Opin Cell Biol2010，22，2： | 1 |
| 15 | Risk factors for ectopicpregnancy in assisted reproduction显示文摘 | Strandell A Thorbum J Hamberger L | 1999 | Fertil Steril1999，71，2： | 1 |
| 16 | Autophagy and cell death 显示文摘 | Yonekawa T Thorbum A | 2013 | Essays Biochem2013，55，： | 1 |
| 17 | Trans- lational evidence that impaired autophagy contributes to arterial ageing 显示文摘 | LAROCCA T J HENSON G D Thorbum A | 2012 | J Physiol2012，590，14： | 1 |
| 18 | The molecular basis of malonyl-CoA decarboxylase deficiency 显示文摘 | FitzPatrick DR Hill A Tolmie JL Thorbum DR Christodoulou J | 1999 | Am J Hum Genet1999，65，2： | 1 |
| 19 | Fructose - induced in vivo insulin resistance and elevated plasma triglyceride levels in rats显示文摘 | Thorbum A W Storlien L H Jenkins A B | 1989 | Am J Clin Nutr1989，49，： | 1 |
| 20 | Autophagy and metas- tasis: another double-edged sword显示文摘 | Kenific CM Thorbum A Debnath J | 2010 | Curr Opin Cell Biol2010，22，2： | 1 |
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