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| 1 | Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison显示文摘AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METHODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared.Thirty-three patients with high-grade dysplasia(HGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment sessions.Fifty-three patients with BD(47 with low-grade dysplasia-LGD,6 with HGD)had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions.Both groups received proton pump inhibitors twice daily.Endoscopic biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for BD.Fisher’s exact test was used to assess differences between the two study groups for primary outcomes.For all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical significance.RESULTS:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,respectively.The CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA.PDT was five times more costly than RFA at our institution.The two groups were not randomized and had different BD grading are the limitations of the study.CONCLUSION:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD. | Atilla Ertan Irum Zaheer Arlene M Correa Nirav Thosani Shanda H Blackmon | 2013 | World Journal of Gastroenterology2013，19，41： | 7 |
| 2 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | Nirav Thosani Harvinder Singh Asha Kapadia Nobuo Ochi Jeffrey H. Lee Jaffer Ajani Stephen G. Swisher Wayne L. Hofstetter Sushovan Guha Manoop S. Bhutani | 2012 | Gastrointestinal Endoscopy2012，，2： | 3 |
| 3 | Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: A meta-analysis显示文摘AIM:To conduct a systematic review and meta-analysis of published population-based randomized controlled trials(RCTs).METHODS:RCTs evaluating the difference in mortality and incidence of colorectal cancer(CRC)between a screening flexible sigmoidoscopy(FS)group and control group(not assigned to screening FS)with a minimum 5 years median follow-up were identified by a search of MEDLINE and EMBASE databases and the Cochrane Central Register for Controlled Trials through August 2013.Random effects model was used for meta-analysis.RESULTS:Four RCTs with a total of 165659 patientsin the FS group and 249707 patients in the control group were included in meta-analysis.Intention-totreat analysis showed that there was a 22%risk reduction in total incidence of CRC(RR=0.78,95%CI:0.74-0.83),31%in distal CRC incidence(RR=0.69,95%CI:0.63-0.75),and 9%in proximal CRC incidence(RR=0.91,95%CI:0.83-0.99).Those who underwent screening FS were 18%less likely to be diagnosed with advanced CRC(OR=0.82,95%CI:0.71-0.94).There was a 28%risk reduction in overall CRC mortality(RR=0.72,95%CI:0.65-0.80)and 43%in distal CRC mortality(RR=0.57,95%CI:0.45-0.72).CONCLUSION:This meta-analysis suggests that screening FS can reduce the incidence of proximal and distal CRC and mortality from distal CRC along with reduction in diagnosis of advanced CRC. | Jennifer Shroff Nirav Thosani Sachin Batra Harminder Singh Sushovan Guha | 2014 | World Journal of Gastroenterology2014，20，48： | 3 |
| 4 | Current progress of immunosrains in Mohs microgwaphic surgery: a review显示文摘 | Thosani MK Marghoob A Chen CS | 2008 | Dermatologic surgery2008，34，12： | 1 |
| 5 | Underwater endo- scopic mucosal resection for recurrences after previous piecemeal resection of colorectal polyps (with video) 显示文摘 | Kim HG Thosani N Banerjee S | 2014 | Gastrointest Endosc2014，80，6： | 1 |
| 6 | Use of a noninvasive continuous monitoring device in the management of atrial fibrillation : a pilot study显示文摘 | Rosenberg MA Samuel M Thosani A | 2013 | Pa- cing Clin Electrophysio12013，36，3： | 1 |
| 7 | Role of EUS-FNA-based cytology in the diagnosis of mucinous pancreatic cystic lesions: a systematic review and meta-analysis显示文摘 | Thosani N Thosani S Qiao W | 2010 | Dig Dis Sci2010，55，： | 1 |
| 8 | Noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in NAFLD显示文摘 | Pearce SG Thosani NC Pan JJ | 2013 | Biomark Res2013，1，1： | 1 |
| 9 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers:a systematic review and meta-analysis显示文摘 | Thosani N Singh H Kapadia A | | 0，，02： | 1 |
| 10 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of su- perficial esophageal cancers:a systematic review and meta- analysis 显示文摘 | Thosani N Singh H Kapadia A | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 11 | Use of a noninvasive continuous monitoring device in the management of atrial fibrillation: a pilot study 显示文摘 | Rosenberg MA Samuel M Thosani A | 2013 | Pacing Clin Electrophysiol2013，36，： | 1 |
| 12 | Diagnostic yield of EUS- FNA-based cytology distinguishing malignant and benign IPMNs:a systematic review and meta-analysis 显示文摘 | Suzuki R Thosani N Annangi S | 2014 | Pancreatology2014，14，5： | 1 |
| 13 | Reduced risk of colorectal cancer with use of oral bisphosphonates:a systematic review and meta-analysis显示文摘 | Thosani N Thosani SN Kumar S | 2013 | J Clin Oncol2013，31，5： | 1 |
| 14 | Endoscopicretrograde cholangiopancreatography for suspected choledo-cholithiasis:Testing the current guidelines显示文摘 | Rubin M I Thosani N C Tanikella R | 2013 | Dig LiverDis2013，15，9086： | 1 |
| 15 | Topotecan is anti-angiogenic in experimental hepatoblastoma显示文摘 | McCrudden KW Yokoi A Thosani A | 2002 | J Pediatr Surg2002，37，： | 1 |
| 16 | Lung cancer-induced paraneoplastic syndromes 显示文摘 | Yeung S C Habra M A Thosani S N | 2011 | Curt Opin Pulm Med2011，17，4： | 1 |
| 17 | Diagnostic accuracy of EUS indifferentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | THOSANI N SINGH H KAPADIA A | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 18 | Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques显示文摘BACKGROUND At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography(ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same period.AIM To evaluate this phenomenon of perceived escalation in complexity of cannulation at ERCP and assessed potential underlying factors.METHODS Demographic/clinical variables and records of ERCP patients at the beginning(2008), middle(2013) and end(2018) of the last decade were reviewed retrospectively. Cannulation approaches were classified as 'standard' or 'advanced' and duodenoscope position was labeled as 'standard'(short position) or 'non-standard'(e.g., long, semi-long).RESULTS Patients undergoing ERCP were older in 2018 compared to 2008(69.7 ± 15.2 years vs 55.1 ± 14.7, P < 0.05). Increased ampullary distortion and peri-ampullary diverticula were noted in 2018(P < 0.001). ERCPs were increasingly performed with a non-standard duodenoscope position, from 2.2%(2008) to 5.6%(2013) and 16.1%(2018)(P < 0.001). Utilization of more than one advanced cannulation technique for a given ERCP increased from 0.7%(2008) to 0.9%(2013) to 6.6%(2018)(P < 0.001). Primary mass size > 4 cm, pancreatic uncinate mass, and bilirubin > 10 mg/d L predicted use of advanced cannulation techniques(P < 0.03 for each).CONCLUSION Complexity of cannulation at ERCP has sharply increased over the past 5 years, with an increased proportion of elderly patients and those with malignancy requiring advanced cannulation approaches. These data suggest that complexity of cannulation at ERCP may be predicted based on patient/ampulla characteristics. This may inform selection of experienced, high-volume endoscopists to perform these complex procedures. | Monique T Barakat Mohit Girotra Nirav Thosani Shivangi Kothari Subhas Banerjee | 2020 | World Journal of Gastroenterology2020，26，41： | 1 |
| 19 | Role of EUS-FNA-based cytology in the diagnosis of mueinous pancreatic cystic lesions: a systematic review and meta-aaalysis 显示文摘 | Thosani N Thosani S Qiao W | 2010 | Dig Dis Sci2010，55，10： | 1 |
| 20 | Are atrial fibrillation patients receiving warfa-rin in accordance with stroke risk显示文摘 | ZIMETBAUM P J THOSANI A YU H T | 2010 | Am J Med2010，123，5： | 1 |
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