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| 1 | LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shutfled let-7b显示文摘 | Ti D Hao H Tong C | 2015 | J Translational Med2015，13，1： | 1 |
| 2 | Efficiency and side effects of anti-CD38 CAR T cells in an adult patient with relapsed B-ALL after failure of bi-specific CD19/CD22 CAR T cell treatment显示文摘(CAR)T cells and immune checkpoint blockade therapies has shown remarkable outcomes in the field of cancer treatment.1,2 In particular,great success has been achieved in B cell acute lymphocytic leukemia(B-ALL)treated with anti-CD19 CAR T cells.2 However,the loss,mutation,and reduced expression of CD19 are crucial causes for the failure of CAR T cell treatment in leukemia patients.3,4 CD38,a 45-kDa type II glycoprotein,is detectable in BALL,and several studies have indicated the efficacy and safety of CD38 monoclonal antibodies in clinical applications,suggesting that CD38 represents a suitable therapeutic target for the treatment of B-ALL.5,6 In addition,we developed a CAR against CD38,and our preclinical study indicated that anti-CD38 CAR T(CAR T-38)cells could specifically lyse CD38-positive tumor cells.7 Herein,we present the anti-leukemia ability of CAR T-38 cells in an adult relapsed B-ALL patient after failure of bi-specific CD19/CD22 CAR T cell treatment,and this administration of CAR T-38 cells was accompanied by the occurrence of target-mediated toxicities and severe and uncontrollable cytokine release syndrome(CRS). | Yelei Guo Kaichao Feng Chuan Tong Hejin Jia Yang Liu Yao Wang Dongdong Ti Qingming Yang Zhiqiang Wu Weidong Han | 2020 | Cellular & Molecular Immunology2020，17，4： | 1 |
| 3 | Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats显示文摘 | Haojie Hao Jiejie Liu Jing Shen Yali Zhao Huilin Liu Qian Hou Chuan Tong Dongdong Ti Liang Dong Yu Cheng Yiming Mu Jianping Liu Xiaobing Fu Weidong Han | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 1 |
| 4 | Versatile optical manipulation of trions,dark excitons and biexcitons through contrasting exciton-photon coupling显示文摘Various exciton species in transition metal dichalcogenides(TMDs),such as neutral excitons,trions(charged excitons),dark excitons,and biexcitons,have been individually discovered with distinct light-matter interactions.In terms of valley-spin locked band structures and electron-hole configurations,these exciton species demonstrate flexible control of emission light with degrees of freedom(DOFs)such as intensity,polarization,frequency,and dynamics.However,it remains elusive to fully manipulate different exciton species on demand for practical photonic applications.Here,we investigate the contrasting light-matter interactions to control multiple DOFs of emission light in a hybrid monolayer WSe2-Ag nanowire(NW)structure by taking advantage of various exciton species.These excitons,including trions,dark excitons,and biexcitons,are found to couple independently with propagating surface plasmon polaritons(SPPs)of Ag NW in quite different ways,thanks to the orientations of transition dipoles.Consistent with the simulations,the dark excitons and dark trions show extremely high coupling efficiency with SPPs,while the trions demonstrate directional chiral-coupling features.This study presents a crucial step towards the ultimate goal of exploiting the comprehensive spectrum of TMD excitons for optical information processing and quantum optics. | Zhe Li Xin-Yuan Zhang Rundong Ma Tong Fu Yan Zeng Chong Hu Yufeng Cheng Cheng Wang Yun Wang Yuhua Feng Takashi Taniguchi Kenji Watanabe Ti Wang Xiaoze Liu Hongxing Xu | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 5 | Regulation of EGFR nanocluster formation by ionic protein-lipid interaction显示文摘表皮的生长因素受体(EGFR ) 的反常激活强烈与许多人的癌症被联系,但是内在的分子的机制充分没被理解。由使用直接随机的光重建显微镜学(dSTORM ) ,我们发现 EGFR 蛋白质在正常的肺的房间膜形成 nanoclusters 簇的上皮的房间和肺癌症房间,而是数字和尺寸显著地在肺癌症房间增加。EGFR 簇的形成被在 anionic 类脂化合物 phosphatidylinositol-4,5-bisphosphate (PIP2 ) 之间的离子的相互作用在血浆膜和 juxtamembrane (JM ) 调停 EGFR 的区域。由 PIP2 弄空或 JM 区域变化聚类的 EGFR 的混乱损害 EGFR 激活并且下游的发信号。而且,在组成地活跃的 EGFR 异种的 JM 区域变化稀释它房间转变的能力。一起,我们的调查结果在 EGFR 发信号和功能加亮 anionic phospholipids 的关键角色,并且揭示新奇机制在癌症解释 EGFR 的异常激活。 | Ye Wang Jing Gao Xingdong Guo Ti Tong Xiaoshan Shi Lunyi Li Miao Qi Yajie Wang Mingjun Cai Junguang Jiang Chenqi Xu Hongbin Ji Hongda Wang | 2014 | Cell Research2014，24，8： | 0 |
| 6 | Super-resolution imaging in glycoscience: New developments and challenges显示文摘Carbohydrates on cell surfaces play a crucial role in a wide variety of biological processes,including cell adhesion,recognition and signaling,viral and bacterial infection,in°ammation and metastasis.However,owing to the large diversity and complexity of carbohydrate structure and nongenetically synthesis,glycoscience is the least understood¯eld compared with genomics and proteomics.Although the structures and functions of carbohydrates have been investigated by various conventional analysis methods,the distribution and role of carbohydrates in cell membranes remain elusive.This review focuses on the developments and challenges of super-resolution imaging in glycoscience through introduction of imaging principle and the available°uorescent probes for super-resolution imaging,the labeling strategies of carbohydrates,and the recent applications of super-resolution imaging in glycoscience,which will promote the super-resolution imaging technology as a promising tool to provide new insights into the study of glycoscience. | Junling Chen Ti Tong Hongda Wang | 2016 | Journal of Innovative Optical Health Sciences2016，9，3： | 0 |
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