| 1 | Expression of survivin protein in human colorectal carcinogenesis显示文摘AIM: To identify the role of survivin in colorectal carcinogenesis and the relationship between Survivin and histological differentiation grade of colorectal carcinoma.METHODS: Immunohistochemical staining of survivin by using the monoclonal antibody was performed by the standard streptavidin-peroxidase (SP) technique for the 188paraffin sections which included 30 normal colorectal mucosas, 41 adenomas with low grade dysplasia, 30adenomas with high grade dysplasia, and 87 colorectal carcinomas which were classified as high, middle and low differentiated subgroups which included 33, 28, 26 cases respectively.RESULTS: Expression of survivin was observed in the cytoplasm of adenoma with dysplasia and colorectal carcinoma cells. No immunoreactivity of survivin was seen in normal mucosas. The positive rate of survivin increased in the transition from normal mucosas to adenomas with low grade dysplasia to high grade dysplasia/carcinomas (0.0 %, 31.7 %, 56.7 % and 63.2% respectively). But the difference between high grade dyspiasia and carcinomas had no statistical significance. Positive rate was not related to histological differentiation grade of colorectal carcinoma.Moreover, there was no correlation between histological differentiation grade of colorectal carcinoma and immunoreactive intensity of survivin.CONCLUSION: The expression of survivin is the essential event in the early stage of colorectal carcinogenesis and plays an important role in the transition sequence and it is not related to histological differentiation grade of colorectal carcinoma. It thus may provide a new diagnostic and therapeutic target in colorectal cancer. | Lian-JieLin Chang-QingZheng YuJin YingMa Wei-GuoJiang TieMa | 2003 | World Journal of Gastroenterology2003，9，5： | 78 |
| 2 | Recent progress in MnBi_(2n)Te_(3n+1)intrinsic magnetic topological insulators:crystal growth,magnetism and chemical disorder显示文摘The search for magnetic topological materials has been at the forefront of condensed matter research for their potential to host exotic states such as axion insulators,magnetic Weyl semimetals,Chern insulators,etc.To date,the MnBi_(2n)Te_(3n+1) family is the only group of materials showcasing van der Waals-layered structures,intrinsic magnetism and non-trivial band topology without trivial bands at the Fermi level.The interplay between magnetism and band topology in this family has led to the proposal of various topological phenomena,including the quantum anomalous Hall effect,quantum spin Hall effect and quantum magnetoelectric effect.Among these,the quantum anomalous Hall effect has been experimentally observed at record-high temperatures,highlighting the unprecedented potential of this family of materials in fundamental science and technological innovation.In this paper,we provide a comprehensive review of the research progress in this intrinsic magnetic topological insulator family,with a focus on single-crystal growth,characterization of chemical disorder,manipulation of magnetism through chemical substitution and external pressure,and important questions that remain to be conclusively answered. | Chaowei Hu Tiema Qian Ni Ni | 2024 | National Science Review2024，11，2： | 0 |
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