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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 3 | Natural convection in porous media bounded by concentric spheres and horizontal cylinders显示文摘 | Burns P J Tien C L | 1979 | Int J Heat Mass transfer1979，，22： | 2 |
| 4 | Preparation and mechanical properties of artificial transversely isotropic rock 显示文摘 | Tien Y M Tsao P F | 2000 | lnt J Rock Mech Min Sci2000，37，6： | 1 |
| 5 | Risk factors of massive bleeding related to pancreatic leak after pancreaticoduodenectomy显示文摘 | Tien Y W Lee P H Yang C Y | 2005 | J Am Coll Surg2005，201，4： | 1 |
| 6 | Preparation and mechanical properties of artificial transversely isotropic rock显示文摘 | Tien Y M Tsao P F | 2000 | International Journals of Rock Mechanics & Mining Science2000，37，6： | 1 |
| 7 | Satellite RNA for thecontrol of plant diseases caused by cucumber mosaicvirus显示文摘 | Tien P Zhang X Qiu B | 1987 | Annals Applied Biology1987，111，： | 1 |
| 8 | Planar lighting by blue LEDs array with remote phosphor显示文摘 | Tien C H Hung C H Xiao B W Huang H T Huang Y P Tsai C C | | 0，，： | 1 |
| 9 | Oxidation of thianthrene by the ligninase of Phanerochaete chrysosporium 显示文摘 | SCHREINER R P STEVENS J R TIEN M | 1988 | Applied and Environmental Microbiology1988，54，7： | 1 |
| 10 | ZnO nanowire growth and devices 显示文摘 | Heo Y W Norton D P Tien L C | 2004 | Materials Science Engineering2004，47，： | 1 |
| 11 | Mitochondrial DNA content affects the fertilizability of human oocytes显示文摘 | Reynier P May-Panloup P Chrétien MF Morgan CJ Jean M Savagner F | 2001 | Mol Hum Reprod2001，7，5： | 1 |
| 12 | Chorea-ballismus with nonketotic hyperglycemia in primary diabetes mellitus显示文摘 | Lai P H Tien R D Chang M H | 1996 | AJNR1996，17，6： | 1 |
| 13 | Development of HS-RT-LAMP (loop-mediated isothermal amplification) system for rapid diagnosis of H5 avian influenza virus infection 显示文摘 | Imai M Ninomiya A Minekawa H Notomi T Ishizaki T Tu P V Tien N T K Tashiro M and Odagiri T | 2006 | Journal of Virological Methods2006，24，44： | 1 |
| 14 | cerebrospinal fluid diversion in endoscopic skull base reconstruction: an evidence-based approach to the use of lumbar drains显示文摘 | TIEN D A STOKKEN J K REC1NOS P F | 2016 | Otolaryngol Clinics North Am2016，49，1： | 1 |
| 15 | ZnO nanowire growth and devices显示文摘 | Heo Y W Norton D P Tien L C | 2004 | Materials Science and Engineering2004，27，12： | 1 |
| 16 | Low velocity impact responses of hol- low core sandwich laminate and interply hybrid laminate显示文摘 | Tien W S Yu H P | 2004 | Compos Struct2004，64，2： | 1 |
| 17 | Differential interferon pathway gene expression patterns in rhabdomyosarcoma cells during enterovirus 71 or coxsackievirus A16 infection 显示文摘 | Zhang W Zhang L Wu Z Tien P | 2014 | Biochem Biophys Res Commun2014，447，3： | 1 |
| 18 | Low velocity impact responses of hollow core sandwich laminate and interply hybrid laminate显示文摘 | TIEN W S YU H P | 2004 | Compos Struct2004，64，： | 1 |
| 19 | Risk factors of massive bleeding related to pancreatic leak after pancreaticoduodenectomy显示文摘 | Tien Y W Lee P H Yang C L | 2005 | J Am Coll Surg2005，201，4： | 1 |
| 20 | Extracellular cyclic GMP and its derivatives GMP and guanosine protect from ox- idative glutamate toxicity显示文摘 | ALBRECHT P HENKE N TIEN ML | 2013 | Neurochem Int2013，62，5： | 1 |
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