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| 1 | Biliary cholesterol secretion: More than a simple ABC显示文摘Biliary cholesterol secretion is a process important for 2 major disease complexes, atherosclerotic cardiovascular disease and cholesterol gallstone disease. With respect to cardiovascular disease, biliary cholesterol secretion is regarded as the f inal step for the elimination of cholesterol originating from cholesterol-laden macrophage foam cells in the vessel wall in a pathway named reverse cholesterol transport. On the other hand, cholesterol hypersecretion into the bile is considered the main pathophysiological determinant of cholesterol gallstone formation. This review summarizes current knowledge on the origins of cholesterol secreted into the bile as well as the relevant processes and transporters involved. Next to the established ATP-binding cassette (ABC) transporters mediating the biliary secretion of bile acids (ABCB11), phospholipids (ABCB4) and cholesterol (ABCG5/G8), special attention is given to emerging proteins that modulate or mediate biliary cholesterol secretion. In this regard, the potential impact of the phosphatidylserine flippase ATPase class Ⅰ type 8B member 1, the Niemann Pick C1-like protein 1 that mediatescholesterol absorption and the high density lipoprotein cholesterol uptake receptor, scavenger receptor class B type Ⅰ, is discussed. | Arne Dikkers Uwe JF Tietge | 2010 | World Journal of Gastroenterology2010，16，47： | 9 |
| 2 | Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein Al 显示文摘 | Tietge UJ Maugeais C Cain W | 2000 | J Biol Chem2000，275，10： | 1 |
| 3 | Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B显示文摘 | Tietge U J F Bakillah A Maugeais C | 1999 | J Lipid Res1999，40，： | 1 |
| 4 | Distinct roles of tYee leptin, bound leptin and soluble leptin receptor during the metabolic-inflam- matory response in patients with liver cirrhosis显示文摘 | Ockenga J Tietge U J Beker KH | 2007 | Aliment Pharma- col Ther2007，25，11： | 1 |
| 5 | Effects of water quality on development of Xenopus laevis:a frog embryo teratogenesis assay- Xenopus assessment of surface water associated with malformations in native anurans显示文摘 | Tietge J E Ankley G T DeFoe D L | 2000 | Environ Toxicol Chem2000，19，： | 1 |
| 6 | Hyperlipidemia and cardiovascular disease: inflam- mation, dyslipidemia, and atherosclerosis显示文摘 | Tietge UJ | 2014 | Curr Opin Lipi- dol2014，25，1： | 1 |
| 7 | Liver transplantation improves hepatic myelopathy:evidence by three cases显示文摘 | Weissenborn K Tietge UJ Bokemeyer M | 2003 | Gas-troenterology2003，124，2： | 1 |
| 8 | Study on An Intermediate Temperature Planar Solid Oxide Fuel Cell显示文摘 | Ullmann H Trofimenko N Tietg F | 2002 | Solid State Ioncis2002，138，： | 1 |
| 9 | Liver transplantation improves hepatic myelopathy: evidence by three cases显示文摘 | WEISSENBORN K TIETGE UJF BOKEMEYER M | 2003 | Gastroenterology2003，124，2： | 1 |
| 10 | Cholesterol efflux and reverse cholesterol transport 显示文摘 | Favari E Chroni A Tietge UJ | 2015 | Hcmdb Exp Pharmacol2015，224，： | 1 |
| 11 | Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabo licin- flammatory response in patients with liver cirrhosis 显示文摘 | Ockenga J Tietge UJ Boker KI-I | 2007 | Aliment Pharmacol Ther2007，25，11： | 1 |
| 12 | Liver transplantation improves hepatic myelopathy: evidence by three cases显示文摘 | Weissenborn K Tietge UJ Bokemeyer M | 2003 | Gastroenterology2003，124，2： | 1 |
| 13 | Liver transplantation improves hepatic myelopathy:Evidence by three cases显示文摘 | WEISSENBORN K TIETGE UJ BOKEMEYER M | 2003 | Gastroenterology2003，24，： | 1 |
| 14 | Liver transplantation improves hepatic myelopathy:evidence by three cases显示文摘 | Weissenborn K Tietge UJ Bokemeyer M | | 0，，02： | 1 |
| 15 | Activated platelets con- tribute to oxidized low-density lipoproteins and dysfunctional high- density lipoproteins through a phospholipase A2-dependent mecha- nism 显示文摘 | Blache D Gautier T Tietge UJF | 2012 | FASEB J2012，26，2： | 1 |
| 16 | Low molecularweight heparin-induced skin necrosis occurring distant from in-jection sites and without thrombocytopenia显示文摘 | Tietge UJ Schmidt HH Jackel E | 1998 | J Intern Med1998，243，4： | 1 |
| 17 | Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase显示文摘 | Maugeais C Tietge UJ Broedl UC | | 0，，17： | 1 |
| 18 | Dose-dependent acceleration of high -density lipoprotein catabolism byendo- thellal lipase显示文摘 | Maugeais C Tietge UJ Broedl UC | 2003 | Circulation2003，108，17： | 1 |
| 19 | Hyperlipidemia and cardiovascular disease: inflammation, dyslipidemia, and atherosclerosis 显示文摘 | Tietge UJ | 2014 | Curt Opin Lipidol2014，25，1： | 1 |
| 20 | Liver transplantation improves hepatic myelopathy: evidence by three cases 显示文摘 | Weissenborn K Tietge U J Bokemeyer M | 2003 | Gastroenterology2003，124，2： | 1 |
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