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| 1 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 2 | Effects of chronic ethanol consumption on rat upper gastrointestinal system: Functional and histologic findings显示文摘 | Yusufhan Yazir Melih Tugay Zafer Utkan Tijen Utkan | 2012 | Alcohol2012，，7： | 2 |
| 3 | Lack of relationship between concentrations of plasma luteinizing hormone, thyroxine, and prolactin at nine weeks of age and subsequent egg production in the domestic hen显示文摘 | Sharp P J Van Tijen W F Middelkoop J H | 1981 | Br Pouh Sci1981，22，： | 1 |
| 4 | Comparative lipid peroxidation,antioxidant defense systems and praline content in roots cultivars differing in salt tolerance显示文摘 | Tijen D Ismail T | 2005 | Environmental and Experimental Botany2005，53，： | 1 |
| 5 | Does exogenous glycinebetaine affect antioxidative system of rice seedlings under NaCl treatment?显示文摘 | Tijen Demiral Ismail Türkan | 2004 | Journal of Plant Physiology2004，，10： | 1 |
| 6 | Interactions of some Schiff base compounds with mild steel surface in hydrochloric acid solution显示文摘 | Emel Bayol Tijen G i rten Ali G rten A | 2008 | Materials Chemistry and Physics2008，，6： | 1 |
| 7 | Interactions of some Schiff base compounds with mild steel surface in hydrochloric acid solution显示文摘 | Emel Bayol Tijen Gürten A. Ali Gürten Mehmet Erbil | 2008 | Materials Chemistry and Physics2008，，2： | 1 |
| 8 | Effects of 24-epibrassinolide on seed germination, seedling growth, lipid peroxidation, proline content and antioxidative system of rice (Oryza sativa L.) under salinity stress显示文摘 | Filiz ?zdemir Melike Bor Tijen Demiral ?smail Türkan | 2004 | Plant Growth Regulation2004，，3： | 1 |
| 9 | Exogenous glycinebetaine affects growth and proline accumulation and retards senescence in two rice cultivar under NaCl stress显示文摘 | Tijen Demiral Ismail Tttrkan | 2006 | Environmental and Experimental Botany2006，，56： | 1 |
| 10 | A fuzzy optimization model for QFD planning process using analytic network approach 显示文摘 | CENGIZ K TIJEN E GULCIN B | 2006 | European Journal of Operational Re- search2006，，171： | 1 |
| 11 | A fuzzy optimization model for QFD planning process using analytic network approach显示文摘 | Cengiz Kahraman Tijen Ertay Gül?in Büyük?zkan | 2004 | European Journal of Operational Research2004，，2： | 1 |
| 12 | Reduced leaf peroxidaseactivity is associated with reduced lignin content in transgenic pop-lar显示文摘 | ZWLIHA I TIJEN O AHU A | 1999 | Plant Biotechnology1999，16，5： | 1 |
| 13 | Esophagitis Impairs Esophageal Smooth Muscle Reactivity in the Rat Model: An In Vitro Study显示文摘 | Melih Tugay Firuzan Yildiz Tijen Utkan Bahar Müezzinoglu Faruk Erden Nejat Gacar Güner Ulak | 2003 | Digestive Diseases and Sciences2003，，11： | 1 |
| 14 | A fuzzy optimizationmodel for QFD planning process using analytic networkapproach显示文摘 | CENGIZ K TIJEN E GULCIN B | 2006 | European Journal of Operational Research2006，171，： | 1 |
| 15 | Reduced leaf peroxidase activity is associated with reduced lignin content in transgenic poplar显示文摘 | Zeliha I Tijen O Ahu A | 1999 | Plant Biotech1999，16，5： | 1 |
| 16 | Reduced leaf peroxidase activity is associated with reduced lignin con-tent in transgenic poplar 显示文摘 | ZELIHA J TIJEN O AHU A | 1999 | Plant Biotech1999，16，5： | 1 |
| 17 | Comparative lipid peroxidation,antioxidant defense systems and proline content in roots of two rice cultivars differing in salt tolerance显示文摘 | TIJEN D ISMAIL T | 2005 | Environmental and Experimental Botany2005，53，2： | 1 |
| 18 | Integrating data envelopment analysis and analytic hierarchy for the facility layout design in manufacturing systems显示文摘 | Tijen Ertay Da Ruan Umut Rifat Tuzkaya | 2006 | Information Sciences2006，176，： | 1 |
| 19 | Interactions of some Schiff base compounds with mild steel surface in hydrochloric acid solution 显示文摘 | Bayola Emel Gurtenb Tijen Gurtena A Ali | 2008 | Materials Chemistry and Physics2008，，： | 1 |
| 20 | Interactions of some Schiff base compounds with mild steel surface in hydrochloric acid solution显示文摘 | Emel Bayol Tijen Gurten Ali Gtirten A | 2008 | Materials Chemistry and Physics2008，，6： | 1 |
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