|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis显示文摘Functional gastrointestinal disorders(FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin's relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate. | Tilemachos Koutouratsas Theodora Kalli Georgios Karamanolis Maria Gazouli | 2019 | World Journal of Gastroenterology2019，25，5： | 14 |
| 2 | Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases:A review显示文摘Inflammatory bowel diseases(IBD)include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated.The intestinal microbiome has been studied as a causal component,with certain microbiotic alterations having been observed in subtypes of IBD.Physical exercise is a modulator of the intestinal microbiome,causing shifts in its composition that are partially corrective of those observed in IBD;furthermore,physical exercise may be beneficial in patients with certain IBD subtypes.This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity’s clinical effects on patients with IBD. | Tilemachos Koutouratsas Anastassios Philippou George Kolios Michael Koutsilieris Maria Gazouli | 2021 | World Journal of Gastroenterology2021，27，30： | 4 |
| 3 | Prospective randomized comparison between ultrasound-guided saphenous nerve block within and distal to the adductor canal with low volume of local anesthetic显示文摘 | Areti Adoni Tilemachos Paraskeuopoulos Theodosios Saranteas Tatiana Sidiropoulou Dimitrios Mastrokalos Georgia Kostopanagiotou | 2014 | Journal of Anaesthesiology Clinical Pharmacology2014，，： | 1 |
| 4 | Gastroenterology and liver disease during COVID-19 and in anticipation of post-COVID-19 era: Current practice and future directions显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has emerged as a major threat to global public health.The virus causes the clinical syndrome known as coronavirus disease 2019(COVID-19),in which multiple organs can get affected.Apart from manifestations of the respiratory system,which predominate,its clinical presentation is frequently accompanied by symptoms of the gastrointestinal(GI)tract and liver abnormalities.The correlation of symptoms and abnormalities with disease severity is discussed,leading to ambiguous results from international literature.Moreover,the disease infects patients with coexisting liver and GI disorders affecting both their health status and the availability of healthcare services provided to them.The risk of transmission of the disease during aerosol-generating procedures has changed the diagnostic approach and follow-up algorithms for liver and GI diseases.For the safety of both doctors and patients,telemedicine and distant evaluation have become everyday practice,whereas several routines and emergency visits at outpatient and emergency departments have been postponed or delayed.Vaccination against SARS-CoV-2 is underway,providing hope to humanity and the expectation that the post-COVID-19 era is near.This review aims to update knowledge about the manifestations of COVID-19 related to liver and GI diseases and the effect of the pandemic on the diagnostic and therapeutic procedures for these diseases with a special focus on how current practices have changed and what changes will possibly remain in the future. | Katerina G Oikonomou Panagiotis Papamichalis Tilemachos Zafeiridis Maria Xanthoudaki Evangelia Papapostolou Asimina Valsamaki Konstantinos Bouliaris Michail Papamichalis Marios Karvouniaris Panagiotis J Vlachostergios Apostolia-Lemonia Skoura Apostolos Komnos | 2021 | World Journal of Clinical Cases2021，9，19： | 0 |
| 5 | Gut microbiome:Linking together obesity,bariatric surgery and associated clinical outcomes under a single focus显示文摘Obesity is increasingly prevalent in the post-industrial era,with increased mortality rates.The gut microbiota has a central role in immunological,nutritional and metabolism mediated functions,and due to its multiplexity,it is considered an independent organ.Modern high-throughput sequencing techniques have allowed phylogenetic exploration and quantitative analyses of gut microbiome and improved our current understanding of the gut microbiota in health and disease.Its role in obesity and its changes following bariatric surgery have been highlighted in several studies.According to current literature,obesity is linked to a particular microbiota profile that grants the host an augmented potential for calorie release,while limited diversity of gut microbiome has also been observed.Moreover,bariatric surgery procedures represent effective interventions for sustained weight loss and restore a healthier microbiota,contributing to the observed fat mass reduction and lean mass increase.However,newer evidence has shown that gut microbiota is only partially recovered following bariatric surgery.Moreover,several targets including FGF15/19(a gutderived peptide),could be responsible for the favorable metabolic changes of bariatric surgery.More randomized controlled trials and larger prospective studies that include well-defined cohorts are required to better identify associations between gut microbiota,obesity,and bariatric surgery. | Konstantinos Georgiou Nikolay A Belev Tilemachos Koutouratsas Hector Katifelis Maria Gazouli | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员