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| 1 | Use of demineralized bone matrix in the extremities显示文摘Autologous bone graft is considered as the gold standard for all indications for bone grafting procedures but the limited availability and complications in donor site resulted in seeking other options like allografts andbone graft substitutes. Demineralized bone matrix(DBM) is an allograft product with no quantity limitation. It is an osteoconductive material with osteoinductive capabilities, which vary among different products, depending on donor characteristics and differences in processing of the bone. The purpose of the present review is to provide a critical review of the existing literature concerning the use of DBM products in various procedures in the extremities. Clinical studies describing the use of DBM alone or in combination with other grafting material are available for only a few commercial products. The Level of Evidence of these studies and the resulting Grades of Recommendation are very low. In conclusion, further clinical studies of higher quality are required in order to improve the Recommendation Grades for or against the use of DBM products in bone grafting procedures. | Georgios I Drosos Panagiotis Touzopoulos Athanasios Ververidis Konstantinos Tilkeridis Konstantinos Kazakos | 2015 | World Journal of Orthopedics2015，6，2： | 4 |
| 2 | Use of demineralized bone matrix in spinal fusion显示文摘Spinal fusion remains the gold-standard treatment for several pathological spine conditions. Although, autologous Iliac Crest Bone Grafting is considered the goldstandard graft choice to promote spinal fusion; however, it is associated with significant donor site morbidity and a limited graft quantity. Therefore, several bone graft alternatives have been developed, to augment arthrodesis. The purpose of this review is to present the results of clinical studies concerning the use of demineralized bone matrix(DBM), alone or as a composite graft, in the spinal fusion. A critical review of the English-language literature was conducted on Pubmed, using key word 'demineralized bone matrix', 'DBM', 'spinal fusion', and 'scoliosis'. Results had been restricted to clinical studies. The majority of clinical trials demonstrate satisfactory fusion rates when DBM is employed as a graft extender or a graft enhancer.Limited number of prospective randomized controlled trials(4 studies), have been performed comparing DBM to autologous iliac crest bone graft in spine fusion. The majority of the clinical trials demonstrate comparable efficacy of DBM when it used as a graft extender in combination with autograft, but there is no clinical evidence to support its use as a standalone graft material. Additionally, high level of evidence studies are required, in order to optimize and clarify the indications of its use and the appropriate patient population that will benefit from DBM in spine arthrodesis. | Konstantinos Tilkeridis Panagiotis Touzopoulos Athanasios Ververidis Sotirios Christodoulou Konstantinos Kazakos Georgios I Drosos | 2014 | World Journal of Orthopedics2014，5，1： | 4 |
| 3 | Total hip replacement using MINIMA^(■)short stem:A short-term follow-up study显示文摘BACKGROUND Total hip replacement has become one of the most successful orthopaedic procedures.The length of the femoral stem constitutes one of the most important geometrical and mechanical features of the prosthesis.Several different implants are currently available but data are limited concerning the clinical results for some of these implants.AIM To report the short-term clinical and radiological results of a novel squared section,tapered design–with four conicity-short stem in total hip replacement.METHODS This is a retrospective study of a prospectively collected data using of MINIMA?short stem in 61 consecutive patients with at least 1 year follow-up.The collected data included patients’demographics,type of arthritis,bone morphology,perioperative data,clinical results using Harris Hip Score,EuroQol(EQ-5D),pain score and satisfaction rate,complications and radiological results.RESULTS Total 61 patients were included in our study with a mean age of 56 years of age(range 25-73 years).The majority of them(68.6%)were women,thirty seven patients(56.9%)were less than 60 years of age and almost half of patients(45.1%)suffered from secondary osteoarthritis(hip dysplasia,osteonecrosis,etc.).The mean time of follow-up examination was 33.4 mo(2.8 years)with a range of 12-57 months(1-4.8 years).In 35 patients(56.9%)the follow-up examination was more than 3 years.No major complications such as revision,periprosthetic fracture,dislocation or infection were presented.Re-admission 90 d postoperatively or laterwas deemed unnecessary for any reason regarding the operation.Respectively,the mean pain score,mean Harris hip score,and mean EQ-5D were improved from 6.3,58.7 and 77.3 preoperatively to 0.1,95.1,and 79.8 postoperatively.The Satisfaction rate at the final follow-up was 9.9(SD 0.3,range 8.0-10.0).All stems were classified as stable bone ingrowth and no radiolucent lineswere revealed in any of the modified Gruens’zone at the postoperative Xrays.Stem subsidence was within acceptable limits and the incidence of distal cortical hypertrophy was relatively low.CONCLUSION The clinical and radiological results concerning the MINIMA?short stem are excellent according to this first report of this specific design of the short femoral stems.Because of the small number of cases and short-term follow-up of this study,a longer follow up time and more patients’enrollment is required. | Georgios I Drosos Stylianos Tottas Ioannis Kougioumtzis Konstantinos Tilkeridis Christos Chatzipapas Athanasios Ververidis | 2020 | World Journal of Orthopedics2020，11，4： | 1 |
| 4 | The treatment of high tibial osteoto-my non-union with the Ilizarov external fixator显示文摘 | Gil ooly JJ Tilkeridis K Simonis RB | | 0，，02： | 1 |
| 5 | Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits显示文摘 | Tilkeridis C Bei T Garantziotis S | 2005 | J Med Genet2005，42，7： | 1 |
| 6 | Long -term results of mitchell's procedure for hallux valgus deformity:a 5-to 20-year followup in 204 cases显示文摘 | Dermon A Tilkeridis C Lyras D | 2009 | Foot Ankle Int2009，30，1： | 1 |
| 7 | Long-term results of mitchell's procedure for hallux valgus deformity: a 5- to 20-year followup in 204 cases显示文摘 | Dermon A Tilkeridis C Lyras D | 2009 | Foot Ankle Int2009，30，1： | 1 |
| 8 | Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits显示文摘 | Tilkeridis C Bei T Garantziotis S | 2005 | J Med Genet2005，42，7： | 1 |
| 9 | Association of a COLIA1 polymorphism with lumbar disc disease in young military recruits显示文摘 | Tilkeridis C Bei T Garantziotis S | 2005 | Journal of Medical Genetics2005，42，7： | 1 |
| 10 | Carpus trans- location into the ipsilateral ulna for distal radius recurrence giant cell tumour: A case report and literature review 显示文摘 | Ververidis AN Drosos GI Tilkeridis KE | 2015 | J Orthop2015，12，1： | 1 |
| 11 | Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits显示文摘 | Tilkeridis C Bei T Garantziotis S | 2005 | J Meal Ganet2005，42，7： | 1 |
| 12 | Association of a COL1A I polymorphism with lumbar disc disease in young military recruits显示文摘 | Tilkeridis C Bei T Garantziotis S Stratakis C A | 2005 | J Med Genet2005，42，： | 1 |
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