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| 1 | Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity. | Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap | 2015 | World Journal of Experimental Medicine2015，5，3： | 2 |
| 2 | A fault tolerance framework for cooperative robotic manipulators显示文摘 | Tinos R Terra M H | 2007 | Control Engineering Practice2007，15，5： | 1 |
| 3 | Anti-enteropalhogenic Escherichia coli imniunoglohulin Y isolated from eggs laid by immunized Leghorn chickens显示文摘 | Tino De Franco M | 2002 | Res Vet Sci2002，72，3： | 1 |
| 4 | Anti-enteropathogenic Escherichia coli immunoglobulin Y isolated from eggs laid by immunized Leghorn chickens显示文摘 | Amaral J A Tino De Franco M Carneiro-Sampaio M M | | 0，，03： | 1 |
| 5 | Fault detection and isolation in robotic manipulators using a multilayer perception and a RBF network trained by the Kohonen's self-organizing map 显示文摘 | Tinos R Terra M H | 2001 | Controley Automacao2001，12，1： | 1 |
| 6 | The apoptosome:emerging insights and new potential targets for drug design显示文摘 | D'Amelio M Tino E Cecconi F | 2010 | Pharm Res2010，25，4： | 1 |
| 7 | Regulation of protein phophorylation and pathogen phagocytosis by surfactant protein A显示文摘 | Schagat T L Tino M J Wright J R | 1999 | Infect Immun1999，67，9： | 1 |
| 8 | The bistatic radar capabilities of the Medicina ra- diotelescopes in space debris detection and tracking显示文摘 | Montebugnoli S Pupillo G Salerno E Pluchino S di Mar- tino M | 2010 | Advances in Space Research2010，45，： | 1 |
| 9 | A fault tolerance framework for cooperative robotic manipulators 显示文摘 | Tinos R Terra M H | 2007 | Control Engineering Praetce2007，15，5： | 1 |
| 10 | Regulation of protein phosphorylation and pathogen phagocytosis by surfactant protein A显示文摘 | Schagat TL Tino M J Wright JR | 1999 | Infect Immun1999，67，9： | 1 |
| 11 | A Fault Tolerance framework for cooperative robotic manipulators 显示文摘 | Tinos R Terra M H | 2007 | Control Engineering Practice2007，15，5： | 1 |
| 12 | anti-enteropathogenic escherichia coli immunobulin Y isolated from eggs laid by immunized leghorn chickens显示文摘 | AMARAL JA TINO DE FRANCO M | 2002 | Res Vet Sci2002，72，3： | 1 |
| 13 | Prostate-specific membrane antigen (PSMA): Current benefits and future value 显示文摘 | Elgamal AA Holmes EH Su SL Tino WT Simmons SJ Peterson M Greene TG Boynton AL Murphy GP | 2000 | Semin Surg Oncol2000，18，1： | 1 |
| 14 | Abstract 18146: Circulating miRNAs In Patients With Coronary Artery Disease显示文摘 | Stephan Fichtlscherer Salvatore De Rosa Henrik Fox Thomas Schwietz Christoph Liebetrau Michael Weber Christian W Hamm Tino Roexe Ariane Fischer Marga Müller-Ardogan Angelika Bonauer Andreas M Zeiher Stefanie Dimmeler | 2010 | Circulation . 2010 (21_M)2010，，： | 1 |
| 15 | Anti-enteropathogenic escherichia coli immunobulin Y isolated from eggs laid by immunised Leghorn chickens显示文摘 | Amaral JA Tino De Franco M Carneiro-Sampaio MM | 2002 | Res Vet Sci2002，72，3： | 1 |
| 16 | Circulating MicroRNAs in Patients With Coronary Artery Disease显示文摘 | Stephan Fichtlscherer Salvatore De Rosa Henrik Fox Thomas Schwietz Ariane Fischer Christoph Liebetrau Michael Weber Christian W. Hamm Tino R?xe Marga Müller-Ardogan Angelika Bonauer Andreas M. Zeiher Stefanie Dimmeler | 2010 | Circulation Research2010，，5： | 1 |
| 17 | Planimetric and volumetric glacier changes in the Khumbu Himal,Nepal,since 1962 using Corona,Landsat TM and ASTER data显示文摘 | BOLCH T BUCHROITHNER M TINO P A K | 2008 | Journal of Glaciology2008，54，187： | 1 |
| 18 | Circulating MicroRNAs in Patients With Coronary Artery Disease显示文摘 | Stephan Fichtlscherer Salvatore De Rosa Henrik Fox Thomas Schwietz Ariane Fischer Christoph Liebetrau Michael Weber Christian W. Hamm Tino R?xe Marga Müller-Ardogan Angelika Bonauer Andreas M. Zeiher Stefanie Dimmeler | 2010 | Circulation Research2010，，5： | 1 |
| 19 | Circulating MicroRNAs in Patients With Coronary Artery Disease显示文摘 | Stephan Fichtlscherer Salvatore De Rosa Henrik Fox Thomas Schwietz Ariane Fischer Christoph Liebetrau Michael Weber Christian W. Hamm Tino R?xe Marga Müller-Ardogan Angelika Bonauer Andreas M. Zeiher Stefanie Dimmeler | 2010 | Circulation Research2010，，5： | 1 |
| 20 | A fault tolerance framework for cooperative robotic manipulators 显示文摘 | Tinos R Terra M H | 2007 | Control Engineering Practice2007，15，5： | 1 |
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