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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Automatic test data generation for path testing using GAS显示文摘 | J C Tin P L Yeh | 2001 | Information Science2001，131，1： | 1 |
| 4 | The shaft resistance of axially loaded Piles in clay 显示文摘 | Potts D M Mas'tins J P | 1982 | Geotechnique1982，32，4： | 1 |
| 5 | Novel brain reactive autoantibodies: prevalence in systemic lupus erythematosus and association with psychoses and seizures显示文摘 | Tin SK Xu Q Thumboo J | 2005 | Neuroimmunol2005，169，12： | 1 |
| 6 | Limita tion of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | WALDRON J TIN M M KELLER A | 2003 | Radiother Oncol2003，68，： | 1 |
| 7 | Visual evoked potential as prognostic factor for vitrectomy in diabetic eyes显示文摘 | Scherfig E Tinning S Edmund J | 1983 | Acta Ophthalmol1983，61，5： | 1 |
| 8 | Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | Waldron J Tin MM Keller A | 2003 | Radiother Oncol2003，68，2： | 1 |
| 9 | Chance-type flexiondistraction injurirs in the thoracolumbar spine : MR imaging characteristies 显示文摘 | Groves C J Cassar-Pullicino VN Tins B J | 2005 | Radiology2005，236，2： | 1 |
| 10 | Autologous chondrocyte implantation in knee joint: Mr imaging and histologic features at 1-year follow-up显示文摘 | Tins B J Mccall IW Takahashi T | 2005 | Radiology2005，234，2： | 1 |
| 11 | A randomized controlled trial to compare steroid with cyclosporine for theopical treatment of oral lichen planus显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 12 | L imitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | Waldron J Tin MM Keller A | 2003 | Radiother Oneo12003，68，2： | 1 |
| 13 | Improved inversion channel mobility for 4H-SiC MOSFETs following high temperature anneals in nitric oxide显示文摘 | CHUNG G Y TIN C C WILLIAMS J R | 2001 | IEEE Electron Devives Letters2001，22，4： | 1 |
| 14 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:a comparative assessment显示文摘 | Elliott A J Tin S Pollock T M | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 15 | Angle closure and angle‐closure glaucoma: what we are doing now and what we will be doing in the future显示文摘 | David S Friedman Paul J Foster Tin Aung Mingguang He | 2012 | Clinical & Experimental Ophthalmology2012，，4： | 1 |
| 16 | Practice of sedation and ana- lgesia in German intensive care units:resuhs of a national sur- vey显示文摘 | Mar tin J Parsch A Martin F | 2005 | Crit Care2005，9，2： | 1 |
| 17 | Gas exchange in litchi under controlled and field conditions显示文摘 | Chang J C tin T S | 2007 | Scientia Horticulturae2007，114，4： | 1 |
| 18 | Silylation and surface properties of chemi- cally grafted hydrophobic silica显示文摘 | CAPEL-SANCHEZ M C BARRIO L CAMPOS-MAR- TIN J M | 2004 | Journal of Colloid and Interface Science2004，277，1： | 1 |
| 19 | Analysis of throm- bopoietin receptor(c-mpl) mRNA expression in de novo acute myeloid leukemia显示文摘 | Schroder JK Kolkenbrock S Tins J | 2000 | Leuk Res2000，24，5： | 1 |
| 20 | p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Star3 显示文摘 | Lin J Tang H Tin X | 2002 | Oncogene2002，21，19： | 1 |
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