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| 1 | Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine显示文摘AIM To compare the impact of tacrolimus(FK) and cyclosporine(CYA) on acute rejection and graft survival and to assess the predominant causes of graft loss between patients receiving these two calcineurin inhibitors(CNIs).METHODS Retrospective review of 1835 patients who received a kidney transplant(KTX) between 1999-2012. Patients were grouped based on initial CNI utilized: 1195 in FK group, 640 in CYA group. Data on baseline characteristics, clinical outcomes, and causes of graft loss in both groups were analyzed. RESULTS Cumulative acute rejection rates were 14% in the FK vs 24% in the CYA group. Despite more marginal donor characteristics in the FK group, these patients had better graft survival rates compared to the CYA group. Three and five year graft survival rates were 88% and 84% respectively in the FK group compared to 79% and 70% respectively in the CYA group(P < 0.001). After multivariate analysis, which controlled for confounders, FK use was a strong predictor for lower acute rejectionrates [odds ratio(OR) 0.60, 95%CI: 0.45-0.79] and better renal allograft survival(OR 0.740, 95%CI: 0.58-0.94). Death with a functioning graft was the most common cause of graft loss in both groups. Common causes of death included cardiovascular disease, infections, and malignancies. Chronic allograft nephropathy was also found to be an important cause of graft loss, being more prevalent in the CYA group. CONCLUSION The use of FK-based maintenance immunosuppression therapy is associated with a significantly lower rate of acute rejection and better graft survival compared to CYA-based regimen. Individualizing immunosuppression through risk-stratified CNI choice may lead to improved outcomes across all spectra of KTX patients. | Mahmoud Kamel Manish Kadian Titte Srinivas David Taber Maria Aurora Posadas Salas | 2016 | World Journal of Transplantation2016，6，4： | 2 |
| 2 | Uric acid,evolution and primitive cultures显示文摘 | Johnson R J Titte S Cade J R | 2005 | Semin Nephrol2005，25，1： | 1 |
| 3 | Topitalcal fundus pulsation measurement in patienes with active central serous chorioretinop- athy显示文摘 | Titt I M Polska E Kireher K | 2003 | Arch Opthamol2003，121，7： | 1 |
| 4 | Dosimetric properties of photon beams from a flattening filter free clinical accelerator显示文摘 | VASSILIEV O N TITT U PONISCH F | 2006 | Phys Med Biol2006，51，7： | 1 |
| 5 | Monte Carlo study of photon fields from a flattening filter-fi'ee clinical accelerator显示文摘 | VASSILIEV O N TITT U STEPHEN F | 2006 | Med Phys2006，33，4： | 1 |
| 6 | 查看详情显示文摘 | Kosterev A A Titte| F K | | 0，，： | 1 |
| 7 | Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field 显示文摘 | Yan X Titt U Koehler A M | 2002 | Nucl Instrum Methods Phys Res2002，，： | 1 |
| 8 | Design tools for proton therapy nozzles based on the double-scattering foil technique 显示文摘 | FONTENOT J D NEWHAUSER W D TITT U | 2005 | Radiattion Protection Dosimetry2005，116，： | 1 |
| 9 | Optical Quantum Memory 显示文摘 | ALEXANDER LVOVSKY I BARRY SANDERS C WOLFGANG TITTE | 2009 | Nature Photon2009，3，： | 1 |
| 10 | Uric acid, evolution, and primitive cultures显示文摘 | Johnson R J Titte S Cade J R | 2005 | Semin Nephrol2005，25，1： | 1 |
| 11 | Dosimetric properties of photon beams from a flattening filter free clinical accerlerator显示文摘 | Vassiliev ON Titt U Ponisch F | 2006 | Phys Med Biol2006，51，7： | 1 |
| 12 | SU-FF-T-279:The validation of a highly detailed multi leaf collimator model by comparing Monte Carlo simulations to measurements显示文摘 | Poenisch F Titt U Vassiliev O | 2005 | Med Phys2005，32，6： | 1 |
| 13 | Low 25-Hydroxyvitamin D Levels and Mortality in Non–Dialysis-Dependent CKD显示文摘 | Sankar D. Navaneethan Jesse D. Schold Susana Arrigain Stacey E. Jolly Anil Jain Martin J. Schreiber James F. Simon Titte R. Srinivas Joseph V. Nally | 2011 | American Journal of Kidney Diseases2011，，4： | 1 |
| 14 | Control analysis of photosynthetic surcrose synthesis:assignment of elasticity coefficients and flux-control coefficients to the cytosolic fructose-1,6-biophatase and surcrose phosphate synthase显示文摘 | S titt M | | 0，，： | 1 |
| 15 | A flattening filter free photon treatment concept evaluation with Monte Carlo显示文摘 | Titt U Vassiliev ON P~inisch F | 2006 | Med Phys2006，33，6： | 1 |
| 16 | Plasma osteopontin:associations with survival and metastasis to bone in men with hormone -refractory prostate carcinoma显示文摘 | Hotte SJ Winquist EW S titt L | 2002 | Cancer2002，95，3： | 1 |
| 17 | A time projection chamber with optical readout for charged particle track structure imaging显示文摘 | Titt U Breskin A Chechik R | 1998 | Nuclear Instruments and Methods in Physics Research Section A1998，416，1： | 1 |
| 18 | Development and application of an optical TPC for charged particle track structure imaging in microdosimetry显示文摘 | Titt U Dangendorf V GroBwendt B | 2002 | Nuclear Instruments and Methods in Physics Research Section A2002，477，1： | 1 |
| 19 | Dosimetric properties of photon beams from a flattening filter free clinical accelerator显示文摘 | Vassiliev ON Titt U Psniseh F | 2006 | Pbys Med Biol2006，51，7： | 1 |
| 20 | Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field 显示文摘 | Yan X Titt U Koehler A M | 2002 | Nuclear Instruments and Methods in Physics Research A2002，476，12： | 1 |
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