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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | High organic loading influences the physical characteristics of aerobic granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，： | 1 |
| 3 | High organic loadinginfluences the physical characteristics of aerobic sludge granules显示文摘 | Moy B Y P Tang J H Toh S K | 2002 | Letters Applied Microbiology2002，34，6： | 1 |
| 4 | High organic loading in- fluences the physical characteristics of aerobic sludge gran- ules显示文摘 | Moy B Y Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，6： | 1 |
| 5 | Prednisolone promotes remission and gastric mucosal regeneration in experimental autoimmune gastritis 显示文摘 | Biondo M Field J Toh B H | 2006 | JPathol2006，209，3： | 1 |
| 6 | High organic loading influences the physical characteristics of aerobic sludge granules 显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Lett Appl Microbiol2002，34，6： | 1 |
| 7 | Investor sentiment and the MAX effect 显示文摘 | F oog W M Toh B | 2014 | Journal of Banking & Finance2014，46，： | 1 |
| 8 | Social capital, economic growth and regional development 显示文摘 | Iyer S Kitson M Toh B | 2005 | Regional Studies2005，39，8： | 1 |
| 9 | High organic loading influences the physical characteristics of aerobic sludge granules 显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，6： | 1 |
| 10 | Size effect on the physical characteristics of the aerobic granule in a SBR显示文摘 | TOH S K TAY J H MOY B Y P | 2003 | Appl Micro Biotech2003，60，6： | 1 |
| 11 | High organic loading in fluences the physical characteristics of aerobic sludgegranules显示文摘 | Tay J H Toh S K | 2002 | Lett Appl Microbiol2002，34，： | 1 |
| 12 | High organic loading influences the physical characteristics of aerobic sludge granules 显示文摘 | MOY B Y P TAY J H TOH S K | 2002 | Lett Appl Micro2002，34，6： | 1 |
| 13 | Gastric H+ ,K+ -daenosine triphosphatase β-subunit is required for normal function, development, and membrane structure of mouse parietal cells显示文摘 | Scarff K L Judd L M Toh B H | 1999 | Gastroenterology1999，117，3： | 1 |
| 14 | High organic loading influences the physical characteristics of aerobic sludge granules 显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，6： | 1 |
| 15 | High organic loading influences the physical characteristics of aerobic sludge granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters Applied Microbiology2002，34，6： | 1 |
| 16 | High organic loading influences the physical characteristics of aerobic sludge granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Lett Appl Microbiol2002，34，： | 1 |
| 17 | High organic loading influences the physical characteristics of aerobic sludge granules 显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Lett Appl Microbiol2002，34，6： | 1 |
| 18 | High organic loading influences the physical characteristics of aerobic sludge granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Lett Appl Microbiol2002，34，6： | 1 |
| 19 | High organic loading influences the physical characteristics of aerobic granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letts Appl Microbiol2002，34，： | 1 |
| 20 | Understanding and measuring circular polarization显示文摘 | Toh B Y | 2003 | IEEE Trans on Education2003，46，3： | 1 |
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