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| 1 | Genomic characterization of esophageal squamous cellcarcinoma:insights from next-generation sequencing显示文摘Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counties, esophageal squamous cell carcinoma(ESCC) accounts for most esophageal malignancies in East Asia, including China and Japan. Technological advances allowing for massively parallel, high-throughput next-generation sequencing(NGS) of DNA have enabled comprehensive characterization of somatic mutations in large numbers of tumor samples. Recently, several studies were published in which whole exome or whole genome sequencing was performed in ESCC tumors and compared with matched normal DNA. Mutations were validated in several genes, including in TP53, CDKN2 A, FAT1, NOTCH1, PIK3 CA, KMT2 D and NFE2L2, which had been previously implicated in ESCC. Several new recurrent alterations have also been identified in ESCC. Combining the clinicopathological characteristics of patients with information obtained from NGS studies may lead to the development of effective diagnostic and therapeutic approaches for ESCC. As this research becomes more prominent, it is important that gastroenterologist become familiar with the various NGS technologies and the results generated using these methods. In the present study, we describe recent research approaches using NGS in ESCC. | Yasushi Sasaki Miyuki Tamura Ryota Koyama Takafumi Nakagaki Yasushi Adachi Takashi Tokino | 2016 | World Journal of Gastroenterology2016，22，7： | 10 |
| 2 | The role of p53-target genes in human cancer 显示文摘 | Tokino T Nakamura Y | 2000 | Crit Rev Oncol Hematol2000，33，： | 1 |
| 3 | The role of P53-target genes in human cancer显示文摘 | TOKINO T NAKAMURA Y | 2000 | Crit Rev Oncol Hematol2000，33，： | 1 |
| 4 | Therapeutic effects of tiopronin on chronic hepatitis:a double-blind clineal study显示文摘 | Icohida F Shibasoki K Tokino I | 1982 | Jint Med Kes1982，10，： | 1 |
| 5 | 查看详情显示文摘 | Wakida T Tokino S Niu S | | 0，，： | 1 |
| 6 | WAF1,a potential mediator of p53 tumor suppression 显示文摘 | El-deiry WS Tokino T Velculescu VE | 1993 | Cell1993，75，： | 1 |
| 7 | WAF1, a potential Mediator of P53 tumor suppression显示文摘 | EL-Deiry WS Tokino T Veleculescu VE | 1993 | Cell1993，75，： | 1 |
| 8 | DNA methylation and cancer pathways in gastrointestinal tumors显示文摘 | Suzuki H Tokino T Shinomura Y | 2008 | Pharmaeogenomics2008，9，12： | 1 |
| 9 | Waf1,a potential mediator of p53tumor suppression显示文摘 | Tokino T Velculescu V E | 1993 | Cell1993，75，： | 1 |
| 10 | P21WAF1,a potential mediator of p53 tumor suppression显示文摘 | EL-Deiry WS Tokino T Velculescu VE | 1993 | Cell1993，75，4： | 1 |
| 11 | WAF1, a potential mediator of p53 tumor suppression 显示文摘 | el-Deiry W S Tokino T Velculescu V E | 1993 | Cell1993，75，4： | 1 |
| 12 | WAF1, a potential mediater of P53 tumour suppression 显示文摘 | EI - Deiry W Tokino T Velculescu VE | 1993 | Cell1993，75，： | 1 |
| 13 | Identifica- tion of ras oncogene mutations in the stool of patientswith curable eolorectal tumors显示文摘 | Sidransky D Tokino T Hamilton SR | 1992 | Science1992，256，5053： | 1 |
| 14 | WAF1, a potential mediator of p53 tumor suppression 显示文摘 | EI- DeryWS Tokino Y Velculescu VE | 1993 | Cell1993，75，4： | 1 |
| 15 | WAFI, a potential mediator of p53 tumor suppression显示文摘 | el-Deity W S Tokino T Velculescu V E | 1993 | Cell1993，75，4： | 1 |
| 16 | The role of p53-target genes in human cancer显示文摘 | Tokino T Nakamura Y | 2000 | Crit Rev Oncol Hematol2000，33，1： | 1 |
| 17 | Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors显示文摘 | SIDRANSKY D TOKINO T KINZLER SR | 1992 | Sci ence1992，256，： | 1 |
| 18 | Surface characteristics of wool and poly fabrics and film treated with Low temperature plasma under atmospheric pre sure显示文摘 | Wakida T Tokino S Niu S | 1993 | Textde Res J1993，63，8： | 1 |
| 19 | WAFI, a potential mediator of p53 tumor suppression 显示文摘 | el-Deiry WS Tokino T Velculescu VE | 1993 | Cell1993，75，4： | 1 |
| 20 | WAFl , a potential mediator of 1753 tumor suppression显示文摘 | El-Deiry WS Tokino T Velculescu VE | 1993 | Cell1993，75，4： | 1 |
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