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| 1 | Shear wave elastography in hepatitis C patients before and after antiviral therapy显示文摘AIM To investigate shear wave(SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response(SVR). METHODS A total of 136 hepatitis C patients [85 patients who had not received antiviral therapy(na?ve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk(SVR group)] and 58 healthy volunteers and outpatients without liver disease(control group) underwent evaluation of liver stiffness by SW elastography(SWE). Various parameters were evaluated in the chronic hepatitis C patients at the time of SWE.RESULTS SW propagation velocity(Vs) was 1.23 ± 0.14 m/s in the control group, 1.56 ± 0.32 m/s in the SVR group, and 1.69 ± 0.31 m/s in the na?ve group. Significant differences were seen between the control group and the SVR group(P = 0.0000) and between the SVR group and the na?ve group(P = 0.01417). All four fibrosis markers were higher in the na?ve group than in the SVR group. In the na?ve group, Vs was positively correlated with alanine aminotransferase(ALT)(r = 0.5372), α feto protein(AFP)(r = 0.4389), type Ⅳ collagen(r = 0.5883), procollagen Ⅲ peptide(P-Ⅲ-P)(r = 0.4140), hyaluronic acid(r = 0.4551), and Mac-2 binding protein glycosylation isomer(M2BPGi)(r = 0.6092) and negatively correlated with albumin(r =-0.4289), platelets(r =-0.5372), and prothrombinactivity(r =-0.5235). On multiple regression analysis, Vs was the most strongly correlated with ALT(standard partial regression std β = 0.4039, P = 0.00000). In the SVR group, Vs was positively correlated with AFP(r = 0.6977), type IV collagen(r = 0.5228), P-Ⅲ-P(r = 0.5812), hyaluronic acid(r = 0.5189), and M2BPGi(r = 0.6251) and negatively correlated with albumin(r =-0.4283), platelets(r =-0.4842), and prothrombin activity(r =-0.4771). On multiple regression analysis, Vs was strongly correlated with AFP(standard partial regression std β = 0.5953, P = 0.00000) and M2BPGi(standard partial regression std β = 0.2969, P = 0.03363).CONCLUSION In hepatitis C patients, liver stiffness is higher in treatment-na?ve patients than in those showing SVR. SWE may be a predictor of hepatocarcinogenesis in SVR patients. | Toshikuni Suda Osamu Okawa Rion Masaoka Yoshinori Gyotoku Naohiko Tokutomi Yasumi Katayama Masaya Tamano | 2017 | World Journal of Hepatology2017，9，1： | 4 |
| 2 | Startup of reactors for anoxic ammonium oxidation: Experiences from the first full-scale anammox reactor in Rotterdam显示文摘 | Wouter R.L. van der Star Wiebe R. Abma Dennis Blommers Jan-Willem Mulder Takaaki Tokutomi Marc Strous Cristian Picioreanu Mark C.M. van Loosdrecht | 2007 | Water Research2007，，18： | 3 |
| 3 | Startup of reactors for anoxic ammonium oxidation: Experiences from the first full-scale anammox reactor in Rotterdam显示文摘 | Wouter R.L. van der Star Wiebe R. Abma Dennis Blommers Jan-Willem Mulder Takaaki Tokutomi Marc Strous Cristian Picioreanu Mark C.M. van Loosdrecht | 2007 | Water Research2007，，18： | 3 |
| 4 | Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas显示文摘 | Kitadai Y Haruma K Tokutomi T | 1998 | Clin Cancer Res1998，4，9： | 1 |
| 5 | Monitoring of severe head-injured patients with transcranial Doppler TCD ultrasonography显示文摘 | Kikuchi N Tokutomi T | 1992 | Acta Neurochir Suppl Wien1992，55，： | 1 |
| 6 | Reconstitution of bluegreen reversible photoconversion of a cyanobacte- rial photoreceptor, PixJ1, in phycocyanobilin-pro- ducing Escherichia coil 显示文摘 | Yoshihara S Shimada T Matsuoka D Zikihara K Kohchi T Tokutomi S | 2006 | Biochemistry2006，45，： | 1 |
| 7 | A novel control method for nitritation: The domination of ammonia-oxidizing bacteria by high concentrations of inorganic carbon in an airlift-fluidized bed reactor显示文摘 | Takaaki Tokutomi Chizu Shibayama Satoshi Soda Michihiko Ike | 2010 | Water Research2010，，14： | 1 |
| 8 | Monitoring of severe headinjured patients with transcranial Doppler ultrasonography显示文摘 | Shigemori M Kikuchi N Tokutomi T | 1992 | Acta Neurochir(Wien)1992，，： | 1 |
| 9 | Characterization of Mandibular Bones in Senile Osteoporotic Mice显示文摘 | Tokutomi K Matsuura T Atsawasuwan P | | 0，，05： | 1 |
| 10 | Signifcance of vessel count and vascular endothelial growth factor in human esophageal carcinoma显示文摘 | Kitadai Y Haruma K Tokutomi T | 1998 | Clin Cancer Res1998，4，9： | 1 |
| 11 | Operation of a nitrite-type airlift reactor at low DO concentration 显示文摘 | Tokutomi T | 2004 | Water Sci Technol2004，49，56： | 1 |
| 12 | Optimal tempera ture for the management of severe traumatic brain injury:effect of hypothermia on intracranial pressure, systemic and intracranial hemodynanmics, and metabolism显示文摘 | Tokutomi T Morimoto K Miyagi T | 2003 | Neurosurgery2003，52，： | 1 |
| 13 | Elevated serum levels of matrix metalloproteinase-9(MMP-9) in Kawasaki disease显示文摘 | Takeshita S Tokutomi T Kawase H | 2001 | Clin Exp Immunol2001，125，2： | 1 |
| 14 | Nitrogen removal from animal waste treatment water by ANAMMOX enrichment 显示文摘 | Waki M Tokutomi T Yokoyama H | 2007 | Bioresour Technol2007，95，： | 1 |
| 15 | Operation of a nitrite type airlift reactor atlow DO concentration 显示文摘 | Tokutomi T | 2004 | Water Sci Technol2004，49，56： | 1 |
| 16 | Recreating an esthetic smile-a muhidisciplinary approach 显示文摘 | Ohyama H Nagai S Tokutomi H | 2007 | Int J Periodontics Restorative Dent2007，27，： | 1 |
| 17 | Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas显示文摘 | Kitadai Y Haruma K Tokutomi T | 1998 | Clin Cancer Res1998，4，： | 1 |
| 18 | Elevated serum levels of matrix metalloproteinase-9(MMP-9)in Kawasaki disease显示文摘 | Takeshita S Tokutomi T Kawase H | 2001 | Clin Exp Immunol2001，125，2： | 1 |
| 19 | Phytochromes confer the photoperiodic control of flowering in rice (a short-day plant) 显示文摘 | IZAWA T OIKAWA T TOKUTOMI S | 2000 | Plant Journal2000，22，5： | 1 |
| 20 | Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas显示文摘 | Kitadai Y Haruma K Tokutomi T | 1998 | Clin Cancer Res1998，4，9： | 1 |
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