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| 1 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 4 | Soot oxidation显示文摘 | Randy L. Vander Wal Aaron J. Tomasek | 2003 | Combustion and Flame2003，，1： | 2 |
| 5 | Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton显示文摘 | Tomasek JJ Halliday NL Updike DL | 1997 | J BiolChem1997，272，： | 2 |
| 6 | Effects of alumina in nonmetallic brake friction materials on friction performance显示文摘 | Tomasek V Kratosova G Yun R P | 2009 | J Mater Sci2009，44，： | 1 |
| 7 | Myofibroblasts and mechano-regulation of connective tissue remodeling显示文摘 | Tomasek JJ Gabbiani G Hinz B | 2002 | Nat Rev Mol Cell Biol2002，3，： | 1 |
| 8 | Bile duct malig- nancies 显示文摘 | Tucek S Tomasek J Hal6mkova J | 2010 | Klin 0nkol2010，23，4： | 1 |
| 9 | Ramucirumab mono- therapy for previously treated advanced gastric or gastro - oesoph-ageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo - controlled, phase 3 trial 显示文摘 | FUCHS CS TOMASEK J YONG CJ | 2014 | Lancet2014，383，9911： | 1 |
| 10 | Myofibroblasts and mechano-regulation of connective tissue remodelling显示文摘 | Tomasek JJ Gabbiani G Hinz B | 2002 | Nat Rev Mol Cell Biol2002，3，5： | 1 |
| 11 | Ramucirumabmonotherapyfor previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma(REGARD):an international,randomised,multicentre,placebo-controlled,Phase 3 trial显示文摘 | Fuchs CS Tomasek J Yong CJ | 2014 | Lancet2014，383，9911： | 1 |
| 12 | Myofibroblasts and mechano-regulation of connective tissue remodelling 显示文摘 | Tomasek JJ Gabbiani G Hinz B | 2002 | Nat Rev Mol Cell Biol2002，3，5： | 1 |
| 13 | Soot nanostructure:Dependence upon synthesis conditions显示文摘 | Vander Wal R L Tomasek A J | 2004 | Combustion andFlame2004，136，1： | 1 |
| 14 | Ramucirumab monothera- py for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma ( REGARD ) : an international, ran- domised, multicentre, placebo-cantrolled, phase 3 trial 显示文摘 | Fuchs CS Tomasek J Yong CJ | 2014 | Lancet2014，383，9911： | 1 |
| 15 | Effects of alumina in nonmetallic brake friction materials on friction perfor- mance显示文摘 | Tomasek V Kratosova G Yun R | 2009 | J Mater Sci2009，44，1： | 1 |
| 16 | Myofibroblasts and mechanoregulation of connective tissue remodelling显示文摘 | Tomasek JJ Gabbiani G Hinz B | 2002 | Nat Rev Mol Cell Biol2002，3，5： | 1 |
| 17 | Myofibroblasts and mechano-regulation of connective tissue remodeling显示文摘 | Tomasek JJ Gabbiani G Hinz B | 2002 | Nat Rev Mol Cell Biol2002，3，5： | 1 |
| 18 | Ramucirumabmonotherapy for previously treated advanced gastric orgastro-oesophageal junction adenocarcinoma (REGARD}:an international, randomised, multicen- tre, placebo-controlled,phase 3 trial显示文摘 | Fuchs CS Tomasek J Yong CJ | 2014 | Lancet2014，383，9911： | 1 |
| 19 | Characteriza-tion of cultured bladder smooth muscle ells:assessment of invitro contractility显示文摘 | KROPP BP ZHANG Y TOMASEK JJ | 1999 | J Urol1999，162，： | 1 |
| 20 | Soot oxidation: Dependence upon initial nanostrucmre显示文摘 | Vander Wal R L Tomasek A J | 2004 | Combustion andFlame2004，134，12： | 1 |
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