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| 1 | Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats显示文摘AIM: To investigate the protective effect of lansoprazoleon ischemia and reperfusion (I/R)-induced rat intestinalmucosal injury in vivo.METHODS: Intestinal damage was induced by clampingboth the superior mesenteric artery and the celiac trunkfor 30 rain followed by reperfusion in male Sprague-Dawleyrats. lansoprazole was given to rats intraperitoneally 1 hbefore vascular clamping.RESULTS: Both the intraluminal hemoglobin and proteinlevels, as indices of mucosal damage, significantlyincreased in I/R-groups comparion with those of sham-operation groups. These increases in intraluminal hemoglobinand protein levels were significantly inhibited by the treatmentwith lansoprazole at a dose of 1 mg/kg. Small intestineexposed to I/R resulted in mucosal inflammation that wascharacterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associatedmyeloperoxidase activity (MPO), and mucosal content of ratcytokine-induced neutrophil chemoattractant-1 (CINC-1).These increases in TBARS, MPO activities and CINC-1 contentin the intestinal mucosa after I/R were all inhibited bypretreatment with lansoprazole at a dose of 1 mg/kg.Furthermore, the CINC-1 mRNA expression was increasedduring intestinal I/R, and this increase in mRNA expressionwas inhibited by treatment with lansoprazole.CONCLUSION: Lansoprazole inhibits lipid peroxidation andreduces development of intestinal mucosal inflammationinduced by I/R in rats, suggesting that lansoprazole mayhave a therapeutic potential for I/R injury. | Hiroshi Ichikawa Norimasa Yoshida Tomohisa Takagi Naoya Tomatsuri Kazuhiro Katada Yutaka Isozaki Kazuhiko Uchiyama Yuji Naito Takeshi Okanoue Toshikazu Yoshikawa | 2004 | World Journal of Gastroenterology2004，10，19： | 10 |
| 2 | Usefulness of vonoprazan,a potassium ion-competitive acid blocker,for primary eradication of Helicobacter pylori显示文摘AIM To investigate usefulness of triple therapy with vonoprazan,a potassium ion-competitive acid blocker and antibiotics,for Helicobacter pylori(H.pylori) eradication.METHODS The H.pylori eradication rate was examined in 2507 patients(2055 undergoing primary eradication and 452 undergoing secondary eradication,excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September 2015.For patients treated from March 2013 to February 2015,a proton pump inhibitor(PPI) was used to reduce acid secretion,while vonoprazan was used after March 2015.The success rates of the 2 regimens(PPI + amoxicillin + clarithromycin/metronidazole,or vonoprazan + amoxicillin + clarithromycin/metronidazole) were compared.RESULTS The success rate of primary H.pylori eradication was significantly higher in the vonoprazan group.When stratified by the underlying disease,a significant increase of the H.pylori eradication rate was observed in patients with chronic gastritis.A significantly lower H.pylori eradication rate was observed in younger patients compared to older patients in the PPI group,but there was no difference according to age in the vonoprazan group.On the otherhand,the success rate of secondary eradication was similar at approximately 90% in both groups.CONCLUSION Vonoprazan is very useful for primary eradication of H.pylori,and may become a first-line acid secretion inhibitor instead of PPIs. | Shinya Yamada Takumi Kawakami Yoshikazu Nakatsugawa Takahiro Suzuki Hideki Fujii Naoya Tomatsuri Hideki Nakamura Hideki Sato Yusuke Okuyama Hiroyuki Kimura Norimasa Yoshida | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 8 |
| 3 | Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion显示文摘Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding. | Muneji Yasuda Hideki Sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura Hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 4 | Edaravone,a newly developed radical scavenger,protects against ischemia-reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 5 | Edaravone, a newly developed radical scavenger, protects against ischemia reperfusion injury ofthe small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 6 | Edaravone,a developed radical scavenger,ischemia-reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 7 | Edaravone,a newly developed radical scavenger,protects against ischemia-reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | | 0，，01： | 1 |
| 8 | Edaromea newly developed radi- cal scavanger,protect against isehemia reperfusion injury of the samll in-testinein rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 9 | Endoscopic submucosal dissection for undifferentiated early gastric cancer as the expanded indication lesion显示文摘 | Kamada K Tomatsuri N Yoshida N | | 0，，02： | 1 |
| 10 | Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intesine in rats 显示文摘 | Tomatsuri N Yoshida N Takaqi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 11 | Edaravone,a newly developed radical scavenger,protects against ischemia reperfusion injury of the small intestine in rats显示文摘 | Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 12 | Edavavone, a newly developed radical scavenger protects againsl is- chemia-reperfusion injury of the small intestine in rats 显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 13 | Edaravone, a newly de- veloped radical scavenger, protects against ischemia - reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，，： | 1 |
| 14 | Cytokine - induced neu- trophil accumulation in the pathogenesis of acute reflux esophagitis in rats显示文摘 | Yamaguchi T Yoshida N Tomatsuri N | 2005 | Int J Mol Med2005，16，1： | 1 |
| 15 | Edaravone , a newly developed radical scavenger, protects against ischemia- reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Tadagi T | 2004 | Int J Med2004，13，1： | 1 |
| 16 | Prevention by Rebamipide of Acute Reflux Esophagitis in Rats显示文摘 | Kazuhiro Katada MD PhD Norimasa Yoshida MD PhD Yutaka Isozaki MD Naoya Tomatsuri MD PhD Hiroshi Ichikawa MD PhD Yuji Naito MD PhD Takeshi Okanoue MD PhD Toshikazu Yoshikawa MD PhD | 2005 | Digestive Diseases and Sciences2005，，1： | 1 |
| 17 | Edaravone, a newly developed radical scavenger, protects against ischemla-reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takaqi T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 18 | Edaravone,a newly developed radical scavenger, protects against ishemia reperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2009 | Int J Mol Med2009，13，1： | 1 |
| 19 | Edaravone,a newly developed radical scavenger,protects against ischemia-reperfusion injury of the small intestine in rats显示文摘 | TOMATSURI N YOSHIDA N TAKAGI T | 2004 | Int J Mol Med2004，13，1： | 1 |
| 20 | Edaravone,a newly developed radical scavenger,protects against ischemiareperfusion injury of the small intestine in rats显示文摘 | Tomatsuri N Yoshida N Takagi T | 2004 | Int J Mol Med2004，13，1： | 1 |
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