| 1 | PM_(2.5) chemical composition and health risks by inhalation near a chemical complex显示文摘Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic constituents.On average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,respectively.Organic compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic acids.Enrichment factors>100 were obtained for Pb,Cd,Zn,Cu,Sn,B,Se,Bi,Sb and Mo,showing the contribution of industrial emissions and nearby major roads.Principal component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound PAHs.Some of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial complex.Photooxidation products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also observed.It was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total OC.The lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As. | Celia Alves Margarita Evtyugina Estela Vicente Ana Vicente Ismael Casotti Rienda Ana Sanchez de la Campa Mario Tome Iola Duarte | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 5 | GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis显示文摘哺乳动物的精子的 Exocytosis 稠密核心的能分泌的小粒作为所有另外的能分泌的房间依靠一样的熔化分子;一个如此的分子是小 GTPase Rab3A。这里,我们由细看 streptolysin O-permeabilized 人的精子的 exocytotic 反应到很多包含 Rab3A 构造的尖锐 applicationof 并且相关报导 Rab3Ain 分泌物的角色的深入的生物化学的描述有那些的调查结果与内长的蛋白质聚在一起。Fulllength, geranylgeranylated,和活跃 Rab3A 得到了人的精子 exocytosis 本身。与 Rab3A/Rab22A 妄想的蛋白质,我们证明 Rab3A 分子的 carboxy 终端领域是足够的 necessaryand 支持 exocytosis,而它的氨基终点的阻止的被触发钙的分泌物。有趣地,当在停靠 acrosome 到血浆膜以后增加了时, fulllength Rab3A 停止了分泌物。这效果看情况到水解 GTP 的 Rab3A 的在无能。我们联合了在单个房间同时染色协议到 detectmembrane 熔化和内长的 Rab3 的激活地位的修改 immunofluorescence 和 acrosomal,并且发现那 GTP hydrolysison 内长的 Rab3 是强制的让熔化毛孔开。我们的调查结果贡献证实 Rab3 调制不同地在学习下面取决于核苷酸界限和 exocytosis 阶段的 regulatedexocytosis。 | Matias A. Bustos Carlos M. Roggero Paola X. De la Iglesia Luis S. Mayorga Claudia N. Tomes | 2014 | Journal of Molecular Cell Biology2014，8，4： | 0 |
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