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| 1 | Recent advances in the surgical treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed. | Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa Rie Yoshida Masashi Isetani | 2014 | World Journal of Gastroenterology2014，20，39： | 24 |
| 2 | Pure laparoscopic hepatectomy for hepatocellular carcinoma with chronic liver disease显示文摘Pure laparoscopic hepatectomy is a less invasive procedure than conventional open hepatectomy for the resection of hepatic lesions. Increases in experiences with the technique, in combination with advances in technology, have promoted the popularity of pure laparoscopic hepatectomy. However, indications for usage and potential contraindications of the procedure remain unresolved. The characteristics and specific advantages of the procedure, especially for hepatocellular carcinoma(HCC) patients with chronic liver diseases,are reviewed and discussed in this paper. For cirrhotic patients with liver tumors, pure laparoscopic hepatectomy minimizes destruction of the collateral blood and lymphatic flow from laparotomy and mobilization, and mesenchymal injury from compression. Therefore, pure laparoscopic hepatectomy has the specific advantage of minimal postoperative ascites production that leads to lowering the risk of disturbance in water or electrolyte balance and hypoproteinemia. It minimizes complications that routinely trigger postoperative serious liver failure. Under adequate patient positioning and port arrangement, the partial resection of the liver in the area of subphrenic space, peri-inferior vena cava area or next to the attachment of retro-peritoneum is facilitated in pure laparoscopic surgery by providing good vision and manipulation in the small operative field.Furthermore, the features of reduced post-operative adhesion, good vision, and manipulation within the small area between the adhesions make this procedure safer in the context of repeat hepatectomy procedures.These improved features are especially advantageous for patients with liver cirrhosis and multicentric and/or metachronous HCCs. | Zenichi Morise Norihiko Kawabe Jin Kawase Hirokazu Tomishige Hidetoshi Nagata Hisanori Ohshima Satoshi Arakawa Rie Yoshida Masashi Isetani | 2013 | World Journal of Hepatology2013，5，9： | 21 |
| 3 | Pure laparoscopic hepatectomy as repeat surgery and repeat hepatectomy显示文摘AIM:To assess clinical outcomes of laparoscopic hepatectomy(LH) in patients with a history of upper abdominal surgery and repeat hepatectomy.METHODS:This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal surgery.Of the 80 patients who underwent LH,22 had prior abdominal surgeries,including hepatectomy(n = 12),pancreatectomy(n = 3),cholecystectomy and common bile duct excision(n = 1),splenectomy(n = 1),total gastrectomy(n = 1),colectomy with the involvement of transverse colon(n = 3),and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen(n = 1).Clinical indicators including operating time,blood loss,hospital stay,and morbidity were compared among the groups.RESULTS:Eighteen of the 22 patients who had undergone previous surgery had severe adhesions in the area around the liver.However,there were no conversions to laparotomy in this group.In the 58 patients without a history of upper abdominal surgery,the median operative time was 301 min and blood loss was 150 m L.In patients with upper abdominal surgical history or repeat hepatectomy,the operative times were 351 and 301 min,and blood loss was 100 and 50 m L,respectively.The median postoperative stay was 17,13 and 12 d for patients with no history of upper abdominal surgery,patients with a history,and patients with repeat hepatectomy,respectively.There were five cases with complications in the group with no surgical history,compared to only one case in the group with a prior history.There were no statistically significant differences in the perioperative results between the groups with and without upper abdominal surgical history,or with repeat hepatectomy.CONCLUSION:LH is feasible and safe in patients with a history of upper abdominal surgery or repeat hepatectomy. | Masashi Isetani Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa | 2015 | World Journal of Gastroenterology2015，21，3： | 13 |
| 4 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 5 | Caudal approach to pure laparoscopic posterior sectionectomy under the laparoscopy-specific view显示文摘AIM:To study our novel caudal approach laparoscopic posterior-sectionectomy with parenchymal transection prior to mobilization under laparoscopy-specific view.METHODS:Points of the procedure are:(1) Patients are put in left lateral position and posterior sector is not mobilized;(2) Glissonian pedicle of the sector is encircled and clamped extra-hepatically and divided afterward during the transection;(3) Dissection of inferior vena cava(IVC) anterior wall behind the liver is started from caudal.Simultaneously,liver transection is performed to search right hepatic vein(RHV) from caudal;(4) Liver transection proceeds to the bifurcation of the vessels from caudal to cranial,exposing the surfaces of IVC and RHV.Since the remnant liver sinks down,the cutting surface is well-opend;and(5) After the completion of transection,dissection of the resected liver from retroperitoneum is easily performed using the gravity.This approach was performed for a 63 years old woman with liver metastasis close to RHV.RESULTS:RHV exposure is required for R0 resection of the lesion.Although the cutting plane is horizontal in supine position and the gravity obstructs the exposure in the small subphrenic space,the use of specific characteristics of laparoscopic hepatectomy,such as the good vision for the dorsal part of the liver and IVC and facilitated dissection using the gravity with the patient positioning,made the complete RHV exposure during the liver transection easy to perform.The operation time was 341 min and operative blood loss was 1356 mL.Her postoperative hospital stay was uneventfull and she is well without any signs of recurrences 14 mo after surgery.CONCLUSION:The new procedure is feasible and useful for the patients with tumors close to RHV and the need of the exposure of RHV. | Hirokazu Tomishige Zenichi Morise Norihiko Kawabe Hidetoshi Nagata Hisanori Ohshima Jin Kawase Satoshi Arakawa Rie Yoshida Masashi Isetani | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 7 |
| 6 | 用于水蒸气重整生物质热解焦油的镍基催化剂的发展(英文)显示文摘Nickel catalysts are effective for the steam reforming of tar derived from biomass pyrolysis,but the improvement is needed in terms of activity,stability,suppression of coke deposition and aggregation,and regeneration.Our recent development of Ni-based catalysts for the steam reforming of tar is reviewed including the modification with CeO2(or MnO),trace Pt,and MgO.The role of additives such as CeO2,MnO,Pt,and MgO is also discussed. | Dalin LI Yoshinao NAKAGAWA Keiichi TOMISHIGE | 2012 | 催化学报2012，33，4： | 4 |
| 7 | Taming heterogeneous rhenium catalysis for the production of biomass-derived chemicals显示文摘Rhenium is one of important components for heterogeneous catalysts,which has been recently used for the catalytic reactions related to the production of biomass-derived chemicals such as deoxydehydration of vicinal OH groups,C-O hydrogenolysis,and hydrogenation of carboxylic acids,and so on.Suitable oxidation state of Re as a catalytic active species is strongly dependent on the catalytic reactions.The control of the oxidation state of Re species on the catalysts is crucial on the catalyst development. | Keiichi Tomishige Yoshinao Nakagawa Masazumi Tamura | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 8 | Reductive Conversion of Biomass-Derived Furancarboxylic Acids with Retention of Carboxylic Acid Moiety显示文摘Catalytic reduction systems of 2-furancarboxylic acid(FCA)and 2,5-furandicarboxylic acid(FDCA)with H 2 without reduction of the carboxyl groups are reviewed.FCA and FDCA are produced from furfural and 5-hydroxymethylfurfural which are important platform chemicals in biomass conversions.Furan ring hydrogenation to tetrahydrofuran-2-carboxylic acid(THFCA)and tetrahydrofuran-2,5-dicarboxylic acid(THFDCA)easily proceeds over Pd catalysts.Hydrogenolysis of one C–O bond in the furan ring produces 5-hydroxyvaleric acid(5-HVA)and 2-hydroxyadipic acid.2-Hydroxyvaleric acid is not produced in the reported systems.5-HVA can be produced as the lactone form(δ-valerolactone;DVL)or as the esters depending on the solvent.These reactions proceed over Pt catalysts with good yields(~70%)at optimized conditions.Hydrogenolysis of two C–O bonds in the furan ring produces valeric acid and adipic acid,the latter of which is a very important chemical in industry and its production from biomass is of high importance.Adipic acid from FDCA can be produced directly over Pt-MoO_(x) catalyst,indirectly via hydrogenation and hydrodeoxygenation as one-pot reaction using the combination of Pt and acid catalysts such as Pt/niobium oxide,or indirectly via two-step reaction composed of hydrogenation catalyzed by Pd and hydrodeoxygenation catalyzed by iodide ion in acidic conditions.Only the two-step method can give good yield of adipic acid at present. | Yoshinao Nakagawa Mizuho Yabushita Keiichi Tomishige | 2021 | Transactions of Tianjin University2021，27，3： | 2 |
| 9 | Novel Catalyst with High Resistance to Sulfur for Hot Gas Cleaning at Low Temperature by Partial Oxidation of Tar Derived from Biomass 显示文摘 | TOMISHIGE K ASADULLAH M KUNIMORI K | 2005 | CatalyCommun2005，，6： | 1 |
| 10 | CERT and intracellular trafficking of ceramide 显示文摘 | Hanada K Kumagai K Tomishige N | 2007 | Biochim Biophys Acta2007，1771，6： | 1 |
| 11 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide显示文摘 | Kudo N Kumagai K Tomishige N | 2008 | Proc Natl Acad Sci USA2008，105，2： | 1 |
| 12 | CO2 reforming of CH4显示文摘 | Tomishige K Fujimoto K | 1998 | Catal Surv Japn1998，，2： | 1 |
| 13 | Glycerol conversion in the aqueous solution under hydrogen over Ru/C + an ion-exchange resin and its reaction mechanism显示文摘 | Tomohisa Miyazawa Yohei Kusunoki Kimio Kunimori Keiichi Tomishige | 2006 | Journal of Catalysis2006，，2： | 1 |
| 14 | Catalytic properties and structure of zireonia catalysts for direct synthesis of dimethyl carbonate from methanol and carbon dioxide显示文摘 | Tomishige K Ikeda Y Sakaihori T | 2000 | Journal of Catalysis2000，192，2： | 1 |
| 15 | Promoting mechanism of potassium in preferential CO oxidation on Pt/Al2O3显示文摘 | KURIYAMA M TANAKA H ITO S KUBOTA T MIYAO T NATIO S TOMISHIGE K KUNIMORI K | 2007 | J Catal2007，252，1： | 1 |
| 16 | Syngas production from methane reforming with CO2/H2O and O2 over NiO-MgO solid solution catalyst in fluidized bed reactors显示文摘 | TOMISHIGE K | 2004 | Catal Today2004，89，4： | 1 |
| 17 | Two sphingolipid transfer proteins, CERT and FAPP2: Their roles in sphingolipid metabolism 显示文摘 | Yamaji T Kumagai K Tomishige N | 2008 | IUBMB Life2008，60，8： | 1 |
| 18 | OPC-67683,a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice显示文摘 | Matsumoto M Hashizume H Tomishige T | 2006 | Plo S Med2006，3，11： | 1 |
| 19 | Preferential CO oxidation in hydrogen-rich stream over Pt catalysts modified with alkali metals:Part II Catalyst characterization and role of alkali metals显示文摘 | TANAKA H KURIYAMA M ISHIDA Y ITO S KUBOTA T MIYAO T NAITO S TOMISHIGE K KUNIMORI K | 2008 | Appl Catal A2008，343，12： | 1 |
| 20 | Preferential CO oxidation in hydrogen-rich stream over Pt catalysts modified with alkali metals:Part I Catalytic performance显示文摘 | TANAKA H KURIYAMA M ISHIDA Y ITO S TOMISHIGE K KUNIMORI K | 2008 | Appl Catal A2008，343，12： | 1 |
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