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| 1 | Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases显示文摘 | Marko NF Angelov L Toms SA Suh JH Chao ST Vogelbaum MA Barnett GH Weil RJ | 2010 | 中国神经肿瘤杂志2010，8，3： | 4 |
| 2 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 3 | Fiducial point placement and the accuracy f point-based,rigid body registration显示文摘 | Fitzpatick JM Toms SA | 2001 | Neurosurgery2001，48，： | 1 |
| 4 | Neurogcncs in the postnatal human epileptic brain显示文摘 | Gonzalez-Martincz JA Bingaman WE Toms SA | 2007 | J Neurosurg2007，107，3： | 1 |
| 5 | Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder显示文摘 | Rodeo SA Hannafin JA Tom J | 1997 | J Orthop Res1997，15，3： | 1 |
| 6 | Fiducial point placement and the accuracy of point-based, rigid body reg istration显示文摘 | West JB Fitzpatrick JM Toms SA | 2001 | Neurosurgery2001，48，4： | 1 |
| 7 | High prevalence of osteoporosis in patients with chronic liver disease prior to liver transplantation显示文摘 | Ninkovic M Love SA Tom B | 2001 | Calcif Tissue Int2001，69，： | 1 |
| 8 | Neurogenes in the postnatal human epileptic brain 显示文摘 | Gonzalez-Martiez JA Bingaman WE Toms SA | 2007 | J Neurosurg2007，107，3： | 1 |
| 9 | Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder显示文摘 | Rodeo SA Hannafin JA Tom J | 1997 | J Orthop Res1997，15，3： | 1 |
| 10 | Fiducial point placement and the Accuracy f point-based,rigid hody registration显示文摘 | Fitzpatick JK Toms SA | 2001 | Neurosurgery2001，48，4： | 1 |
| 11 | Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder显示文摘 | Rodeo SA Hannafin JA Tom J | | 0，，03： | 1 |
| 12 | Clinical problem-solving:island intruder显示文摘 | Toms SA Weil RJ Gupta A et a 1 | | 0，，： | 1 |
| 13 | Fiducial point placement and the Accuracy of point-based, rigid body registration 显示文摘 | West JB Fitzpatick JK Toms SA et ol | 2001 | Neurosurgery2001，48，4： | 1 |
| 14 | Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity显示文摘 | Toms SA Lin WC Weil RJ | 2005 | Neurosurgery2005，57，4： | 1 |
| 15 | Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder显示文摘 | Rodeo SA Hannafin JA Tom J | 1997 | J Orthop Res1997，15，3： | 1 |
| 16 | In vivo brain tumor demarca- tion using optical spectroscopy 显示文摘 | Lin WC Toms SA Johnson M | 2001 | Photochem Photobiol2001，73，4： | 1 |
| 17 | Clinical problem- solving: island intruder 显示文摘 | Toms SA Weil RJ Gupta A | 2008 | Neurosurgery2008，62，4： | 1 |
| 18 | Intraoperative optical spectros- copy identifies infiltrating glioma margins with high sensitivity显示文摘 | Toms SA Lin WC Weil R J | 2007 | Neumsurgery2007，6，1： | 1 |
| 19 | Neurogene- sis in the postnatal human epileptic brain 显示文摘 | Gonzalez-Martfnez JA Bingaman WE Toms SA | 2007 | J Neurosurg2007，107，3： | 1 |
| 20 | Fiducial point placement and the accuracy of point-based,rigid body registration显示文摘 | West JB Fitzpatrick JM Toms SA | 2001 | Neurosurgery2001，48，4： | 1 |
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