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| 1 | Severe cutaneous adverse drug reactions: a review on epidemiology, etiology, clinical manifestation and pathogenesis显示文摘目的将在严重的皮肤的不利的药反应(SCADR ) 的传染病学,病原学,临床的表明,和 pathophysiology 考察当前的进步。数据来源数据被使用 Blackwell 协同作用, PubMed,在主要中国杂志出版的原来的文章和相关医药课本材料获得。在整个文学的学习选择和日期抽取考察 49 篇文章被选择。然而,结果 SCADR 盒子是稀罕的含意是与重要 mortatity 率威胁的生活。传染病学研究从不同区域,性,年龄,赛跑和并发的病显示出各种各样的发生。为 SCADR 的每种类型有典型症状,但是这不那么总是是。与导致 SCADR 联系的药是 anticonvulsants,抗菌素, NSAID 和治疗风湿药剂药。在一些国家,特别在亚洲,传统的药是 offen SCADR 的原因。基因多型性和病毒的感染是 SCADR 的倾向因素。有某些基因等位基因和内在的疾病的病人对 SCADR 脆弱。SCADR 的准确致病不是明确的。尽管如此,最近的学习证明反应代谢物和免疫学的过程在 SCADR 有一个重要角色。不同 SCADR 反应被不同内在的因素归因的结论例如象外来的因素一样的基因多型性,性,年龄和赛跑,例如内在的疾病。不同区域和犯人药也在 SCADR 的各种各样的类型起一个作用。 | Tomy Martin LI Hui | 2008 | Chinese Medical Journal2008，，8： | 18 |
| 2 | 重症药疹85例临床分析显示文摘目的探讨重症药疹的临床特点及防治措施。方法对本科2002年8月-2013年11月诊治的重症药疹患者的临床资料进行回顾性分析。结果排名前三位的致敏药物分别为抗生素、抗癫痫药和解热镇痛药,最常见用药原因为感染。中成药引起的药疹内脏损害相对较轻。85例患者中,治愈61例,好转23例,1例死于肺部感染及呼吸衰竭。结论重症药疹是皮肤科危重病种,早期予以糖皮质激素联合免疫球蛋白效果较好,同时应加强对症及支持治疗。 | 申卉 Tomy Martin 李惠 | 2015 | 中国皮肤性病学杂志2015，29，4： | 8 |
| 3 | 嗜酸性粒细胞增多综合征1例显示文摘1病历摘要
患者男,63岁。因全身红斑、丘疹伴瘙痒5年,加重1个月,于2007年1月10日入院。患者5年前无明显诱因腹部出现红斑及米粒大丘疹,伴剧烈瘙痒,影响睡眠。患者曾自服中药(具体不详),病情可好转。丘疹逐渐蔓延至胸部、臀部、四肢、颈部及头部,无季节性变化。入院1个月瘙痒加重。余无异常。家族中无类似疾病患者。 | Tomy Martin 李惠 陈爱军 | 2008 | 临床皮肤科杂志2008，37，3： | 4 |
| 4 | Composition of the Essential Oils of Ocimum canum, O. gratissimum and O. minimum显示文摘 | Ana Martins Lígia Salgueiro Roser Vila Félix Tomi Salvador Ca?igueral Joseph Casanova António da Cunha Tomás Adzet | 1999 | Planta Med1999，，02： | 1 |
| 5 | Distribution of hexabromocyclododecane in Detroit river suspended sediments 显示文摘 | Martin C H Tomy G T Alaee M | 2006 | Chemosphere2006，64，： | 1 |
| 6 | MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination显示文摘Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality.There remains a medical need for vaccines against these pathogens.CMV(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a lifetime.Hence,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous pathogens.We generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(S)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over time.Importantly,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T cells.Conclusively,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens. | Yeonsu Kim Xiaoyan Zheng Kathrin Eschke M.Zeeshan Chaudhry Federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On Julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte Stephan Ludwig Martin Messerle Carlos Guzman Ofer Mandelboim Michael Hust Stefan Pöhlmann Stipan Jonjić LukaČičin-Šain | 2022 | Cellular & Molecular Immunology2022，19，2： | 0 |
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