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| 1 | A dual-pass data assimilation scheme for estimating surface fluxes with FY3A-VIRR land surface temperature显示文摘In this work, a dual-pass data assimilation scheme is developed to improve predictions of surface flux. Pass 1 of the dual-pass data assimilation scheme optimizes the model vegetation parameters at the weekly temporal scale, and Pass 2 optimizes the soil moisture at the daily temporal scale. Based on ensemble Kalman filter(EnKF), the land surface temperature(LST) data derived from the new generation of Chinese meteorology satellite(FY3A-VIRR) are assimilated into common land model(CoLM) for the first time. Six sites, Daman, Guantao, Arou, BJ, Miyun and Jiyuan, are selected for the data assimilation experiments and include different climatological conditions. The results are compared with those from a dataset generated by a multi-scale surface flux observation system that includes an automatic weather station(AWS), eddy covariance(EC) and large aperture scintillometer(LAS). The results indicate that the dual-pass data assimilation scheme is able to reduce model uncertainties and improve predictions of surface flux with the assimilation of FY3A-VIRR LST data. | XU TongRen LIU ShaoMin XU ZiWei LIANG ShunLin XU Lu | 2015 | Science China Earth Sciences2015，58，2： | 9 |
| 2 | Regional and Global Land Data Assimilation Systems: Innovations,Challenges, and Prospects显示文摘Since the North American and Global Land Data Assimilation Systems(NLDAS and GLDAS) were established in2004, significant progress has been made in development of regional and global LDASs. National, regional, projectbased, and global LDASs are widely developed across the world. This paper summarizes and overviews the development, current status, applications, challenges, and future prospects of these LDASs. We first introduce various regional and global LDASs including their development history and innovations, and then discuss the evaluation, validation, and applications(from numerical model prediction to water resources management) of these LDASs. More importantly, we document in detail some specific challenges that the LDASs are facing: quality of the in-situ observations, satellite retrievals, reanalysis data, surface meteorological forcing data, and soil and vegetation databases; land surface model physical process treatment and parameter calibration; land data assimilation difficulties; and spatial scale incompatibility problems. Finally, some prospects such as the use of land information system software, the unified global LDAS system with nesting concept and hyper-resolution, and uncertainty estimates for model structure,parameters, and forcing are discussed. | Youlong XIA Zengchao HAO Chunxiang SHI Yaohui LI Jesse MENG Tongren XU Xinying WU Baoqing ZHANG | 2019 | Journal of Meteorological Research2019，33，2： | 7 |
| 3 | Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle显示文摘mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering etc.However,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application.Here we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized mRNAs.mRNAs encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA formulations.It was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and hepatocytes.The maximum amount of protein expression was found at 6 h post-administration.The expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized mRNA.Moreover,no toxicity or immunogenicity was observed for these mRNA formulations.Therefore,our study provides a useful and promising platform for mRNA therapeutic development. | Tongren Yang Chunhui Li Xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai Liang Haihua Xiao Xing-Jie Liang Yuhua Weng Yuanyu Huang | 2020 | Bioactive Materials2020，5，4： | 7 |
| 4 | Anatomic structural study of cerebellopontine angle via endoscope显示文摘在颅骨底依靠寻找内视镜的技术的可能的解剖基础的背景最低限度地侵略的外科是争论的。这研究的目的是在 cerebellopontine 角度区域观察在主要的血容器和神经之间的空间关系并且为侧面、以后的颅骨底提供解剖基础经由内视镜的 retrosigmoid 锁眼 approach.Methods 的最低限度地侵略的外科这研究在三十个弄干的成年颅骨上被进行测量空间关系在之中出现以后的头部的窝的多骨的标记,并且为 retrosigmoid 锁眼 ap 定位最适当的钻区域在直径与 2.0 厘米在这个点上集中的一个洞对在 cerebellopontine 角度暴露相关结构合适。 Retrosigmoid 锁眼途径罐头减少小脑上的压力并且有效地暴露相关结构它包括面部神经, vestibulocochlear 神经,三叉的神经,舌与喉的神经,迷走神经神经,附件神经,舌下神经神经,前面的劣等的小脑的动脉,以后的劣等的小脑的动脉和迷宫的动脉,内诊镜 retrosigmoid 途径上的准确地点能避免在最低限度地侵略的外科期间拖小脑的 etc.Conclusions 。retrosigmoid 锁眼途径的申请将扩大内视镜的技术的申请。 | XIA Yin LI Xi-ping HAN De-min ZHENG Jun LONG Hai-shan SHI Jin-feng Department of Otolaryngology,Beijing Tongren Hospital,Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing 100730,China (Xia Y,Li XP,Han DM,Zheng J,Long HS and Shi JF) | 2007 | Chinese Medical Journal2007，，20： | 7 |
| 5 | Changes in Global Cloud Cover Based on Remote Sensing Data from 2003 to 2012显示文摘As is well known,clouds impact the radiative budget,climate change,hydrological processes,and the global carbon,nitrogen and sulfur cycles.To understand the wide-ranging effects of clouds,it is necessary to assess changes in cloud cover at high spatial and temporal resolution.In this study,we calculate global cloud cover during the day and at night using cloud products estimated from Moderate Resolution Imaging Spectroradiometer(MODIS)data.Results indicate that the global mean cloud cover from 2003 to 2012 was 66%.Moreover,global cloud cover increased over this recent decade.Specifically,cloud cover over land areas(especially North America,Antarctica,and Europe)decreased(slope=–0.001,R^2=0.5254),whereas cloud cover over ocean areas(especially the Indian and Pacific Oceans)increased(slope=0.0011,R^2=0.4955).Cloud cover is relatively high between the latitudes of 36°S and 68°S compared to other regions,and cloud cover is lowest over Oceania and Antarctica.The highest rates of increase occurred over Southeast Asia and Oceania,whereas the highest rates of decrease occurred over Antarctica and North America.The global distribution of cloud cover regulates global temperature change,and the trends of these two variables over the 10-year period examined in this study(2003–2012)oppose one another in some regions.These findings are very important for studies of global climate change. | MAO Kebiao YUAN Zijin ZUO Zhiyuan XU Tongren SHEN Xinyi GAO Chunyu | 2019 | Chinese Geographical Science2019，29，2： | 5 |
| 6 | Anomalous pancreaticobiliary junction: image analysis and treatment principles显示文摘BACKGROUND: Anomalous pancreaticobiliary junction is often associated with biliary tract carcinoma and acute pan- creatitis. We assessed the value of image analysis in the diag- nosis of patients with anomalous pancreaticobiliary junction (APBJ) and the principles for the treatment of APBJ. METHODS: Sixty-four patients with APBJ were subjected to ultrasound imaging, endoscopic retrograde cholangio- pancreatography (ERCP) and magnetic resonance cholan- giopancreatography (MRCP) before surgery. The diagnos- tic accuracy of image analysis and their surgical outcomes were evaluated retrospectively. RESULTS: On ERCP and MRCP, the length of the com- mon channel was calculated to be 15 mm or longer in all patients, and the angle of the junction was more than 75° in 49 (76.6%) of the 64 patients. Of the 64 patients, 28 were defined of pancreatic duct type (P-C) (28/64, 43.75%), 32 bile duct type (C-P) (32/64, 50%), and 4 common chan- nel type (4/64, 6.25%). CONCLUSIONS: Patients with APBJ are often associated with biliary tract and pancreatic diseases, and early detec- tion and correct surgical treatment could avoid serious complications. ERCP and MRCP are accurate in the diag- nosis of APBJ. | Ze-Li Yu, Li-Jun Zhang, Jian-Zhu Fu, Jie Li, Qing-Yu Zhang and Fou-Lai Chen Beijing, China Department of General Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 3 |
| 7 | Protective effect of liver ischemic preconditioning on rat hepatocytes显示文摘Ischemic preconditioning (IPC) protects liver graft function following ischemia in liver transplantation and liver resection. The aim of this study was to assess the advantages and any potential disadvantages of liver IPC prior to isolation for rat hepatocytes during isolation and cryopreservation. After isolating and thawing the cryopreserved hepatocytes after 14 and 28 d,cell viability,efficiency,and lactate dehydrogenase (LDH) levels in preserve solution were examined for every group. Groups treated with IPC had better cell viability determination,assessment of plating efficiency and lactate dehydrogenase (LDH) assay than Group without IPC,suggesting that IPC prior to isolation may have a significant protective effect on hepatocytes subjected to isolation and short period cryopreservation. | FU JianZhu1,2,WANG Yu1,ZHANG LiJun2 & YU ZeLi2 1 Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China 2 Department of General Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China | 2009 | Science China(Life Sciences)2009，52，9： | 3 |
| 8 | Retrieval of Land-surface Temperature from AMSR2 Data Using a Deep Dynamic Learning Neural Network显示文摘It is more difficult to retrieve land surface temperature(LST) from passive microwave remote sensing data than from thermal remote sensing data, because the emissivities in the passive microwave band can change more easily than those in the thermal infrared band. Thus, it is very difficult to build a stable relationship. Passive microwave band emissivities are greatly influenced by the soil moisture, which varies with time. This makes it difficult to develop a general physical algorithm. This paper proposes a method to utilize multiple-satellite, sensors and resolution coupled with a deep dynamic learning neural network to retrieve the land surface temperature from images acquired by the Advanced Microwave Scanning Radiometer 2(AMSR2), a sensor that is similar to the Advanced Microwave Scanning Radiometer Earth Observing System(AMSR-E). The AMSR-E and MODIS sensors are located aboard the Aqua satellite. The MODIS LST product is used as the ground truth data to overcome the difficulties in obtaining large scale land surface temperature data. The mean and standard deviation of the retrieval error are approximately 1.4° and 1.9° when five frequencies(ten channels, 10.7, 18.7, 23.8, 36.5, 89 V/H GHz) are used. This method can effectively eliminate the influences of the soil moisture, roughness, atmosphere and various other factors. An analysis of the application of this method to the retrieval of land surface temperature from AMSR2 data indicates that the method is feasible. The accuracy is approximately 1.8° through a comparison between the retrieval results with ground measurement data from meteorological stations. | MAO Kebiao ZUO Zhiyuan SHEN Xinyi XU Tongren GAO Chunyu LIU Guang | 2018 | Chinese Geographical Science2018，28，1： | 3 |
| 9 | Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy显示文摘CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool,that relies on Cas9 protein and single guided RNA(sgRNA)to edit target DNA.However,the lack of safe and efficient delivery carrier is one of the crucial factors restricting its clinical transformation.Here,we report an ionizable lipid nanoparticle(iLP181,pKa=6.43)based on iLY1809 lipid enabling robust gene editing in vitro and in vivo.The iLP181 effectively encapsulate psgPLK1,the best-performing plasmid expressing for both Cas9 protein and sgRNA targeting Polo-like kinase 1(PLK1).The iLP181/psgPLK1 nanoformulation showed uniformity in size,regular nanostructure and nearly neutral zeta potential at pH 7.4.The nanoformulation effectively triggered editing of PLK1 gene with more than 30%efficiency in HepG2-Luc cells.iLP181/psgPLK1 significantly accumulated in the tumor for more than 5 days after a single intravenous injection.In addition,it also achieved excellent tumor growth suppression compared to other nucleic acid modalities such as siRNA,without inducing adverse effects to the main organs including the liver and kidneys.This study not only provides a clinically-applicable lipid nanocarrier for delivering CRISPR/Cas system(even other bioactive molecules),but also constitutes a potential cancer treatment regimen base on DNA editing of oncogenes. | Chunhui Li Tongren Yang Yuhua Weng Mengjie Zhang Deyao Zhao Shuai Guo Bo Hu Wanxuan Shao Xiaoxia Wang Abid Hussain Xing-Jie Liang Yuanyu Huang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 10 | Gradual upregulation of OCI-5 expression during occurrence and progression of rat hepatocellular carcinoma显示文摘BACKGROUND: OCI-5, the rat homologene of human glypican 3 ( GPC3), is confirmed upregulated in hepatocellular carcinoma (HCC). The present study was undertaken to detect gene expression change of OCI-5 during occurrence and progression of rat HCC. METHODS: Male Sprague-Dawley rats were given diethyl-nitrosamine ( DENA) to induce HCC. Three DENA-induced rats and one control rat were sacrificed every week for 18 weeks during the development of HCC. Tissues specimens were snap-frozen in liquid nitrogen and total RNA was isolated. Sk-Hepl cells were treated with DENA at different concentrations. The gene expression levels of OCI-5 and GPC3 were detected with the RT-PCR method. RESULTS: OCI-5 was not expressed in normal rat liver tissues. When HCC occurred and aggravated, OCI-5 expression was gradually elevated to a very high level. GPC3 was not expressed in the DENA-treated Sk-Hepl cells. CONCLUSIONS: OCI-5 was not expressed in normal rat liver tissues but in rat HCC tissues. High-expression of OCI-5 in DENA-induced rat HCC model was the gene expression change of HCC not the DENA-induced gene expression. The expression level of OCI-5 was not only elevated in rat HCC but also gradually along the occurrence and progression of HCC, indicating that GPC3 might serve as a sensitive marker of early stage HCC. | Wei-Jun Jiang, Xiao-Bo Man, Liang Tang, Hong-Yin Song, Shen-Jing Li, Guo-Jun Cai, Xiu-Hua Qiu and He-Ping Hu Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai 200050, China Department of Gastroenterology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Department of Phannacology, Second Military Medical University, Shanghai 200433, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 2 |
| 11 | Upregulation of TGF-beta,FOXP3, and CD4^+ CD25^+ regulatory T cells correlates with more rapid parasite growth in human malaria infection 显示文摘 | Walther M Tongren JE Andrews L | 2005 | Immunity2005，23，3： | 1 |
| 12 | Travel plans of the over-65 market pre and postretirement显示文摘 | TONGREN H N | 1980 | Journal of Travel Research1980，19，2： | 1 |
| 13 | The nonlinear osicilation on the resonance points显示文摘 | DING Tongren | 1982 | Science in China(Ser A)1982，，1： | 1 |
| 14 | Research Advances in Post-Operative Rehabilitation Following Cochlear Implant显示文摘Cochlear implantation is a unique method to re-construct audition for patients with severe to profound hearing loss. With increasing clinical application of this technique, its rehabilitative effects in patients has become an important topic of hearing and speech rehabilitation research. This article is an overview of hearing and speech rehabilitative training, rehabilitative efficacy evaluation and factors affecting rehabilitation efficacy following cochlear implantation. | LI Yong-xin1, LIANG Shuang2, HAN De-min1 1 Beijing Tongren Hospital, Affiliate of Capital Medical University 2 Capital Medical University, Beijing Tongren Hospital, Post-graduate | 2007 | Journal of Otology2007，2，2： | 1 |
| 15 | Malaria vaccines: if at first you don't succeed显示文摘 | Tongren JE Zavala F Roos DS | 2004 | Trends Parasitol2004，20，12： | 1 |
| 16 | Upregulation of TGF-beta, FOXP3, and CD4 * CD25 + regulatory T cells corre- lates with more rapid parasite growth in human malaria infection 显示文摘 | Walther M Tongren JE Andrews L | 2005 | Immunity2005，23，3： | 1 |
| 17 | Malaria vacant: if at first you don't succeed显示文摘 | Tongren JE Zavala F Rooe DS | 2004 | Trends Parasitol2004，20，12： | 1 |
| 18 | The war be- tween the ma]aria parasite and the immune system: immunity, immunoregulation and immunopathology显示文摘 | Artavanis-Tsakonas K Tongren JE Riley EM | 2003 | Ciin Exp Immu- nol2003，133，2： | 1 |
| 19 | The war between the malaria parasite and the immune system: immunity, immuno- regulation and immunopathology 显示文摘 | Artavanis-Tsakonas K Tongren JE Riley EM | 2003 | Clin Exp Immunol2003，133，2： | 1 |
| 20 | Retinoblastoma in a young adult mimicking Coats'disease显示文摘Retinoblastoma is the most common childhood primary intraocular malignancy, with the majority of cases being diagnosed before 5 years of age. Retinoblastoma in adults is extremely rare. Here, we report the case of a 20-year-old man who presented with a 3 year history of blurred vision in the right eye. Imaging did not reveal the typical presentation of retinoblastoma. After considering Coats' disease, a diagnosis of late-presenting retinoblastoma was made through cytological analysis. Diagnosis of retinoblastoma should be considered in the presence of uncertain mass lesions in the fundus of an adult. | Zheng Zhang, Ji-Tong Shi, Ning-Li Wang, Jian-Min Ma Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Vision Science Key Lab, Beijing 100730, China | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 1 |
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