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| 1 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 2 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 3 | Regional and Global Land Data Assimilation Systems: Innovations,Challenges, and Prospects显示文摘Since the North American and Global Land Data Assimilation Systems(NLDAS and GLDAS) were established in2004, significant progress has been made in development of regional and global LDASs. National, regional, projectbased, and global LDASs are widely developed across the world. This paper summarizes and overviews the development, current status, applications, challenges, and future prospects of these LDASs. We first introduce various regional and global LDASs including their development history and innovations, and then discuss the evaluation, validation, and applications(from numerical model prediction to water resources management) of these LDASs. More importantly, we document in detail some specific challenges that the LDASs are facing: quality of the in-situ observations, satellite retrievals, reanalysis data, surface meteorological forcing data, and soil and vegetation databases; land surface model physical process treatment and parameter calibration; land data assimilation difficulties; and spatial scale incompatibility problems. Finally, some prospects such as the use of land information system software, the unified global LDAS system with nesting concept and hyper-resolution, and uncertainty estimates for model structure,parameters, and forcing are discussed. | Youlong XIA Zengchao HAO Chunxiang SHI Yaohui LI Jesse MENG Tongren XU Xinying WU Baoqing ZHANG | 2019 | Journal of Meteorological Research2019，33，2： | 7 |
| 4 | Molecular imaging of tumor angiogenesis using RGD-labeled iron oxide nanoparticles显示文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy. | WU XinYing ZHANG JingFeng LIN BingYing ZHANG MinMing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 5 | Research on the Necessity of Building National-level Grape and Cherry Germplasm Resources Bank in Shandong Province显示文摘At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products. Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion. However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45% of those in the US and 27. 2% of those in the EU. Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong. Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province. Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future; advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries; push forward the construction and development of cherry and grape mutants banks. It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding. Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of ' production,study and research' going side by side. | Pengfei WANG Fengshan REN Yongmei WANG Xinying WU Xilong JIANG Yingchun CHEN Shan WANG Qian MU Liying YANG Wanjun CHEN | 2018 | Agricultural Biotechnology2018，7，2： | 3 |
| 6 | Neuropeptide Y gene transfection inhibits post-epileptic hippocampal synaptic reconstruction显示文摘Exogenous neuropeptide Y has antiepileptic effects; however, the underlying mechanism and optimal administration method for neuropeptide Y are still unresolved. Previous studies have used intracerebroventricular injection of neuropeptide Y into animal models of epilepsy. In this study, a recombinant adeno-associated virus expression vector carrying the neuropeptide Y gene was injected into the lateral ventricle of rats, while the ipsilateral hippocampus was injected with kainic acid to establish the epileptic model. After transfection of neuropeptide Y gene, mossy fiber sprouting in the hippocampal CA3 region of epileptic rats was significantly suppressed, hippocampal synaptophysin (p38) mRNA and protein expression were inhibited, and epileptic seizures were reduced. These experimental findings indicate that a recombinant adeno-associated virus expression vector carrying the neuropeptide Y gene reduces mossy fiber sprouting and inhibits abnormal synaptophysin expression, thereby suppressing post-epileptic synaptic reconstruction. | Fan Zhang Wenqing Zhao Wenling Li Changzheng Dong Xinying Zhang Jiang Wu Na Li Chuandong Liang | 2013 | Neural Regeneration Research2013，8，17： | 2 |
| 7 | Identification of Differentially Expressed Genes in Grape Skin at Veraison and Maturity and Construction of Co-expression Network显示文摘The ripening process of grape is an important stage during grape growth and development. During this process, color of grape skin is the most obvious change. The molecular mechanism for the ripening of grape(a non-climacteric fruit, which ripens without ethylene and respiration bursts) is still unclear. Although numerous studies have been done on the changes in the contents of metabolites during grape ripening, the differentially expressed genes at veraison and maturity stages have not been systematically analyzed. In this study, 1 524 genes that are significantly differentially expressed in grape(Pinot Noir) skin at veraison and maturity stages were identified, and a co-expression network of these genes was built. Some of the eight co-expression modules we identified may be closely related to the synthesis or metabolism of anthocyanins, sugar acids, and other flavor substances. The transcription factor families WRKY, b ZIP, HSF and WOX may play an important role in the regulation of anthocyanin synthesis or metabolism. The results provide a foundation for further study of the molecular mechanism of grape ripening. | Pengfei WANG Xilong JIANG Xinying WU Ling SU Lei GONG Hongmei SHI Fengshan REN Yongmei WANG | 2017 | Agricultural Science & Technology2017，18，11： | 2 |
| 8 | Formation of dynamic membrane in an anaerobic membrane bioreactor for municipal wastewater treatment显示文摘 | Xinying Zhang Zhiwei Wang Zhichao Wu Fenghai Lu Jun Tong Lili Zang | 2010 | Chemical Engineering Journal2010，，1： | 1 |
| 9 | Membrane fouling in an anaerobic dynamic membrane bioreactor (AnDMBR) for mu- nicipal wastewater treatment: Characteristics of membrane foulants and bulk sludge 显示文摘 | Zhang Xinying Wang Zhiwei Wu Zhichao | 2001 | Process Biochemistry2001，46，8： | 1 |
| 10 | Formation of dynamic membrane in an anaerobic membrane bioreactor for municiple wasterwater treatment显示文摘 | Zhang Xinying Wang Zhiwei Wu Zhichao | | 0，，1： | 1 |
| 11 | MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling显示文摘As a subtype of non-small-cell lung cancer,lung squamous cell carcinoma(LUSC)accounts for one-fifth of all lung cancers.Unfortunately,no specific targetable aberration has yet been identified.Hence,it is of huge urgency and potential to identify aberrantly regulated genes in LUSC.Here,five pairs of LUSC samples and their corresponding adjacent tissues were subject to whole transcriptome sequencing.Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG,LNC_000378,RP11-116G8.5,RP3-523K23.2,and RP5_968D22.1 were significantly upregulated in all five LUSC samples.Importantly,MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines.Interestingly,our results demonstrated that the expression level of MIR205HG is positively correlated with the malignancy.In addition,MIR205HG is required for LUSC cell growth and cell migration.Most importantly,our results showed that MIR205HG prohibits LUSC apoptosis via regulating Bcl-2 and Bax.Taken together,our data shed lights on the IncRNA regulatory nexus that controls the carcinogenesis of LUSC and provided potential novel diagnostic markers and therapeutic targets for LUSC. | Yan Chang Xinying Xue Chunsun Li Wei Zhao Yongfu Ma Fei Xu Zhen Wu Yu Dai Yunjing Li Yang Liu Liang’an Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 1 |
| 12 | Formation of dynamic membrane in an anaerobic membrane bioreactor for municipal wastewater treatment显示文摘 | ZHANG Xinying WANG Zhiwei WU Zhichao | 2010 | Chemical Engineering Journal2010，165，： | 1 |
| 13 | Co-word analysis of the trends in stem cells field based on subject heading weigh- ting 显示文摘 | An Xinying Wu Qingqiang | 2011 | Scientometrics2011，88，1： | 1 |
| 14 | Co-word analysis of the trends in stem cells field based on subject heading weighting显示文摘 | An Xinying Wu Qingqiang | 2011 | Scientometrics2011，88，1： | 1 |
| 15 | Membrane fouling in an anaerobic dynamic membrane bioreactor(AnDMBR) for mu- nicipal wastewater treatment:characteristics of membrane foulants and bulk sludge显示文摘 | Zhang Xinying Wang Zhiwei Wu Zhichao | 2011 | Process Biochemistry2011，46，8： | 1 |
| 16 | STK 11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in P eutz– J eghers Syndrome显示文摘 | Zhiqing Wang Baoping Wu Rebecca A. Mosig Yulan Chen Fei Ye Yali Zhang Wei Gong Lanbo Gong Fei Huang Xinying Wang Biao Nie Haoxuan Zheng Miao Cui Yadong Wang Juan Wang Chudi Chen Alexandros D. Polydorides David Y. Zhang John A. Martignetti Bo Jiang | 2014 | Human Mutation2014，，7： | 1 |
| 17 | Isobaric vapor–liquid equilibrium for methanol<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>dimethyl carbonate<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>phosphoric-based ionic liquids显示文摘 | Fufeng Cai Xinying Wu Chang Chen Xiaochun Chen Charles Asumana Md Razibul Haque Guangren Yu | 2013 | Fluid Phase Equilibria2013，，： | 1 |
| 18 | Membrane fouling in an anaerobic dynamic membrane bioreactor (AnDMBR)for municipal wastewater treatment:Characteristics of membrane foulants and bulk sludge 显示文摘 | Zhang Xinying Wang Zhiwei Wu Z|fichao | 2011 | Process Biochemistry2011，，46： | 1 |
| 19 | Farm and environment information bidirectional acquisition sys- tem with individual tree identification using smartphones for orchard precision management 显示文摘 | Qian Jianping Yang Xinying Wu Xiaoming | 2015 | Computers and E- lectronics in Agriculture2015，，116： | 1 |
| 20 | A NIR ratiometric fluorescent biosensor for sensitive detection and imaging of α-L-fucosidase in living cells and HCC tumor-bearing mice显示文摘Detection and imaging of α-L-fucosidase(AFU)is of great value to understand its roles in hepatocellular carcinoma(HCC)and tumor early diagnosis,but ideal assays are still lacking.Herein,a near-infrared(NIR)fluorescent biosensor(α-Fuc-DCM)was elaborately designed and synthesized for rapid and ratiometric detection of AFU activity in cells and HCC tumor mouse models.In the presence of AFU,this biosensor shows an enhancement in NIR emission in a ratiometric manner,which significantly improves the detection accuracy with the limit of detection as low as 4.8 mU/mL.Taking advantage of these merits,the activity of AFU in lysosomes could be visualized using ratiometric and NIR dual modality in living cells.Furthermore,its remarkable application for monitoring of endogenous AFU activity in HCC tumor-bearing mouse model is also demonstrated with bright fluorescence signal,which indicated that the biosensor could clearly monitor the liver tumor in the early stage.Importantly,the α-Fuc-DCM probe can be utilized to detect the AFU in serum from HCC patients.This strategy offers a promising biosensor system for early diagnosis of HCC and studying the roles of AFU in cancers. | Guo-Qiang Zhang Weiwei Feng Zhiyuan Gao Gao-Lan Zhang Xinying Wu Yating Xiao Xun Li Lei Zheng Dan Ding Jianshuang Guo Bo Situ | 2023 | Aggregate2023，4，2： | 0 |
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