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| 1 | 意大利设计显示文摘意大利设计以其深厚的文化底蕴、丰赡的设计理念、新锐的设计风格走在国际设计的前沿,并对世界各国的设计产生了一定的影响。本期专题延请了意大利资深设计师和设计理论、设计教育的专家及国内研究意大利设计的学者、对意大利设计的社会性与文化性、与科技、手工艺相结合的设计创新对工业发展的影响、意大利设计与教育体系、文化价值的关系、以及备受关注的米兰国际没计周等方面做了深入的研究,给中国的设计界以深刻的启发。 | Tonino Paris 陈欣 郑慧 | 2011 | 创意与设计2011，，3： | 3 |
| 2 | Hepatitis C virus infection and health-related quality of life显示文摘Hepatitis C virus(HCV) hepatitis and other diseases related to HCV,such as cryoglobulinemia,lymphoma and renal failure,impair health-related quality of life(HRQoL).In addition,HCV per se might directly influence HRQoL via colonization of microglia in the brain or,indirectly,via the effect of systemic inflammatory cytokines which,in turn,can trigger brain interleukin production.The treatment of HCV-related disorders with interferon(IFN) has an effect on HRQoL.Initially,IFN causes a transient deterioration of HRQoL,due to the induction of depression and other side effects of treatment.Subsequently,the subjects who obtain a sustained virologic response experience an improvement in HRQoL.Only rarely does interferon treatment causes permanent detrimental effects on HRQoL,due to residual psychiatric or neurologic side effects.Liver transplantation is the only treatment for end-stage HCV-related liver disease.HRQoL generally improves massively a few months after transplantation,except in the case of serious complications of the transplant procedure.Furthermore,high levels of anxiety and neuroticism pre-transplant are associated with lower HRQoL one year after transplant.Additionally,six months after transplant,patients with HCV who experience virologic recurrence show significantly greater depression,anxiety,phobic anxiety,and paranoid ideation than anti-HCV-negative patients.In conclusion,optimal care for the overall well-being of patients with HCV infection requires adequate knowledge of their neurological and psychological status. | Piero Amodio Laura Salari Sara Montagnese Sami Schiff Daniele Neri Tonino Bianco Lina Minazzato | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 3 | Hepatitis C virus relies on lipoproteins for its life cycle显示文摘Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production. | Germana Grassi Giorgia Di Caprio Gian Maria Fimia Giuseppe Ippolito Marco Tripodi Tonino Alonzi | 2016 | World Journal of Gastroenterology2016，22，6： | 3 |
| 4 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘 | Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne | 2010 | Journal of the American College of Cardiology2010，，3： | 2 |
| 5 | Fractional flow reserve versus angiography for guiding percutaneous coronary interven- tion in patients with muhivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiog- raphy for Multivessel Evaluation) study 显示文摘 | Pijls NH Fearon WF Tonino PA | 2010 | J Am Coil Cardiol2010，56，3： | 1 |
| 6 | A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome显示文摘 | Claudia M Tonino E Rosa D P | 2002 | Diabetes2002，51，7： | 1 |
| 7 | Relationship between VEGFand p53 expression and tumor cell proliferation in human gas-trointestinal carcinomas显示文摘 | Montero E Abreu C Tonino P | 2008 | J Can Res Clin Oncol2008，134，2： | 1 |
| 8 | Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease显示文摘 | PIJLS N H FEARON W F TONINO P A | 2010 | J Am Coll Cardiol2010，56，： | 1 |
| 9 | Cost-Effectiveness of Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease and Abnormal Fractional Flow Reserve显示文摘 | William F. Fearon David Shilane Nico H.J. Pijls Derek B. Boothroyd Pim A.L. Tonino Emanuele Barbato Peter Jüni Bernard De Bruyne Mark A. Hlatky | 2013 | Circulation2013，，12： | 1 |
| 10 | Fractionalfow reserve versus angiography for guiding percutaneous coronary intervention 显示文摘 | Tonino P A De Bruyne B Pijls N H | 2009 | N Engl J Med2009，360，3： | 1 |
| 11 | Fractional flow reserve versus angiography for guiding percutaneous coronary intervention显示文摘 | Tonino PA De Bruyne B Pijls NH | | 0，，03： | 1 |
| 12 | Benefits of drug-eluting stents as compared to bare metal stent in ST-segment elevation myocardial infarction: Four year results of the P aclit A xel or S irolimus- E luting stent vs bare metal stent in primary angiOplasty (PASEO) randomized trial显示文摘 | Emilio Di Lorenzo Rosario Sauro Attilio Varricchio Michele Capasso Tonino Lanzillo Fiore Manganelli Ciro Mariello Francesco Siano Maria Rosaria Pagliuca Giovanni Stanco Giuseppe Rosato Giuseppe De Luca | 2009 | American Heart Journal2009，，： | 1 |
| 13 | Fractional flow reserve versus angiography for guiding percutaneous coronary intervention 显示文摘 | Tonino PA De Bruyne B Pijls NH | 2009 | NEnglJMed2009，360，3： | 1 |
| 14 | Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation显示文摘 | Tonino PA Fearon WF De Bruyne B | 2010 | J Am Coil Cardiol2010，55，25： | 1 |
| 15 | Fractional flow reserve versus angiography for guiding percutaneous coronary intervention 显示文摘 | Tonino PA De Bruyne B Pijls NHJ | 2009 | N Engl J Med2009，360，3： | 1 |
| 16 | Angiographic versus functional serversity of coronary artery stenosis in the FAME study fractional flow reserve versus angiography in multivessel cvlauation 显示文摘 | Tonino PA Fearon WF De Bruyne B | 2010 | J Am Coll Cariol2010，55，25： | 1 |
| 17 | Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study显示文摘 | Pim A.L. Tonino William F. Fearon Bernard De Bruyne Keith G. Oldroyd Massoud A. Leesar Peter N. Ver Lee Philip A. MacCarthy Marcel van’t Veer Nico H.J. Pijls | 2010 | Journal of the American College of Cardiology2010，，25： | 1 |
| 18 | Angiographicversus functional severity of coronary artery stenoses in theFAME study fractional flow reserve versus angiography inmultivessel evaluation显示文摘 | Tonino PA Fearon W F De Bruyne b | 2010 | J Am Coll Cardiol2010，55，25： | 1 |
| 19 | Chest pain in sickle cell disease显示文摘 | Tonino SH Nur E Otten HM | 2013 | The Netherlands journal of medicine2013，71，5： | 1 |
| 20 | Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography inmultivessel evaluation显示文摘 | Tonino PA Fearon WF De Bruyne B | 2010 | J Am Coil Cardiol2010，55，25： | 1 |
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