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| 1 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 2 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 3 | Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery显示文摘·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and placebo-controlled.The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery.Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group.In group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P <0.05)].In addition,the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70?à3.89)mmHg,(P <0.05)],but there was no significant difference between group 2 [(16.16?à5.23)mmHg] and control group at 8 hours (P >0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.· | Haydar Erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa Kemal Arici Aysen Topalkara | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 1 |
| 4 | Central corneal thickness and Diaton transpalpebral tonometry显示文摘 | Toler MI Vural A Erdogan H Topalkara A Arici MK | 2008 | Graefes Arch Clin Exp Ophthalmol2008，246，6： | 1 |
| 5 | Sonic hedgehog reg- ulates ischemia/hypoxia-induced neural progenitor prolif- eration显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，11： | 1 |
| 6 | Sonie hedgehog regulates ischemia/ hypoxia-induced neural pvgenitor prolifera- tion显示文摘 | SIMS J R LEE S W TOPALKARA K | 2009 | Stroke2009，40，11： | 1 |
| 7 | Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，： | 1 |
| 8 | Additive effect of latanoprost and dorzolamide in patients with elevated intraocular pressure显示文摘 | Kimal AM Topalkara A Guler C | 1998 | Int Ophthalmol1998，22，1： | 1 |
| 9 | Conjunctival marginal zone B-cell lym- phoma (MALT lymphoma) with amyloid and relapse in the stomach显示文摘 | TOPALKARA A BEN-ARIE-WEINTROB Y FER- RY J A | 2007 | Ocul Immuno] Inflamm2007，15，： | 1 |
| 10 | Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，11： | 1 |
| 11 | Sonic hedgehog regulates ische- mia/hypoxia-induced neural progenitor proliferation 显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，11： | 1 |
| 12 | Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor prolifera- tion 显示文摘 | SIMS JR LEE SW TOPALKARA K | 2009 | Stroke2009，40，11： | 1 |
| 13 | Sonic hedgehog regulates ischemia/hypoxia-indueed neural progenitor proliferation显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，： | 1 |
| 14 | Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation 显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，，40： | 1 |
| 15 | Additive effect of latanoprost and dorzolamide in patients with elevated intraocular pressure 显示文摘 | KIMAL A M TOPALKARA A GlJLER C | 1998 | lnt Opthalmol1998，22，1： | 1 |
| 16 | Extracapsular cataract extraction with posterior chamber lens implantation in capsular glaucoma 显示文摘 | Arici MK Topalkara A Demircan S | 2000 | Ophthalmologica2000，214，4： | 1 |
| 17 | Adverse effects of topical antiglaucoma drugs on the ocular surface 显示文摘 | Arici MK Arici DS Topalkara A | 2000 | Clin Exp Ophthalmol2000，28，2： | 1 |
| 18 | Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation显示文摘 | John R. Sims Sae-Won Lee Kamil Topalkara Jianhua Qiu Jian Xu Zhipeng Zhou Michael A. Moskowitz | 2009 | Stroke2009，，11： | 1 |
| 19 | Suppres- sion of cardiac parasympathetic functions in patients with right hemispheric stroke显示文摘 | ERCIYAS A H TOPALKARA K TOPAKTAS S | 1999 | Eur J Neurol1999，6，6： | 1 |
| 20 | Sonic hedgehog regulates ischemia/hypoxia induced neural progenitor pro- liferation 显示文摘 | Sims JR Lee SW Topalkara K | 2009 | Stroke2009，40，11： | 1 |
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