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| 1 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 2 | The roles of platelet function,thromboxane,blood lipids and nitric oxide in hypertension of children and adolescents显示文摘 | Bereczki C Ssllai E Torday C | 2000 | Prostaglandins Leukot Essent Fatty Acids2000，62，： | 1 |
| 3 | Leptin mediates the parathyroid hormone - related protein paracrine stimulation of fetal lung maturation显示文摘 | Torday JS Sun H Wang L | 2002 | Am J Physiol Lung Cell Mol Physiol2002，282，3： | 1 |
| 4 | The PAN module,the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins 显示文摘 | Tordai H Banyai L Patthy L | 1999 | FEBS Lett1999，461，： | 1 |
| 5 | Am J Physiol Lung Cell显示文摘 | Torday JS Rehan VK Stretch - stimulated surfactant synthesis is coordinated by the paracrina actions of PTHrP and leptin | 2002 | Mol Physiol2002，283，1： | 1 |
| 6 | Investigation of insertion/deletion polymorphism of the ACE gene in stroke patients显示文摘 | Pongracz E Tordai A Csornai M | 2002 | Ideggyogy Sz2002，55，56： | 1 |
| 7 | PIK3CA activating mu tations and chemotherapy sensitivity in stage Ⅱ-Ⅲ breast cancer显示文摘 | Liedtke C Cardone L Tordai A | 2008 | Breast Cancer Res2008，10，2： | 1 |
| 8 | PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer 显示文摘 | Liedtke C Cardone L Tordai A | 2008 | Breast Cancer Res2008，10，2： | 1 |
| 9 | Elevated concentrations of the beta-subunit of human chorionic gonadotropin and testosterone in the amniotic fluid of gestations of diabetic mothers 显示文摘 | Barbieri RL Sahzman DH Torday JS | 1986 | Am J Obstet Gynecol1986，154，5： | 1 |
| 10 | 1α,25-Dihydroxy-3-epi-vitamin D 3 , a natural metabolite of 1α,25-dihydroxy vitamin D 3 : production and biological activity studies in pulmonary alveolar type II cells显示文摘 | Virender K Rehan John S Torday Sara Peleg Lynn Gennaro Paul Vouros James Padbury D Sunita Rao G Satyanarayana Reddy | 2002 | Molecular Genetics and Metabolism2002，，1： | 1 |
| 11 | Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation显示文摘 | Torday JS Sun H Wang L | | 0，，： | 1 |
| 12 | 1 alpha, 25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1 alpha, 25-dihydroxy vitamin I)3: production and bio- logical activity studies in pulmonary alveolar type II cells显示文摘 | Rehan VK Torday JS Peleg S Gennaro L Vouros P Padbury J | 2002 | Mol Genet Metab2002，76，1： | 1 |
| 13 | Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation显示文摘 | Torday JS Sun H Wang L | 2002 | Physiol Lung Cell Mol Physiol2002，282，3： | 1 |
| 14 | 1 a, 25-dihydroxy -3-epi-vitamin D3,a natural metabolite of la, 25-dihydroxy vitamin D3 :production and biological activity studies in pulmonary alveolartype II cells显示文摘 | Rehan VK Torday JS Peleg S | 2002 | Mol Genet Metab2002，76，1： | 1 |
| 15 | Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin显示文摘 | Torday JS Rehan VK | 2002 | Physiol Lung Cell Mol Physiol2002，283，1： | 1 |
| 16 | Time - dependence of boundary tensions of solutions I:The role of diffusion in time - effects 显示文摘 | WARD A TORDAI L | 1946 | The Joun-al of Chemical Physics1946，14，7： | 1 |
| 17 | Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia显示文摘 | Torday JS Rehan VK | 2007 | Pediatr Res2007，62，1： | 1 |
| 18 | The pulmonary li pofibroblast (lipid interstitial cell) and its coutributions to alveolar development 显示文摘 | McGowan SE Torday JS | 1997 | AnnuRev Physiol1997，59，： | 1 |
| 19 | Inflammatory breast cancer- comparing the effectivity of preoperative docetaxel-epirubieine protocol to conventional antracycline-containing chemotherapy to achieve clinical benefit and complete pathological response显示文摘 | Horvth Z Torday L Hitre E | 2011 | Pathol Oncol Res2011，17，3： | 1 |
| 20 | PIK3CA-activa ting mutations and chemotherapy sensitivity in stage II- III breast cancer 显示文摘 | Liedtke C Cardone L Tordai A | 2008 | Breast Cancer Res2008，10，2： | 1 |
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