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| 1 | New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury显示文摘AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine 1-phophate.METHODS: We divided Sprague-Dawley rats into 4 groups: control, HA, sphingosine 1-phosphate(S1P), and HA-S1 P. After the administration of each agent, we subjected the rat livers to total ischemia followed by reperfusion. After reperfusion, we performed the following investigations: alanine aminotransferase(ALT), histological findings, Td T-mediated d UTP-biotin nick end labeling(TUNEL) staining, and transmission electron microscopy(TEM). We also investigated the expressionof proteins associated with apoptosis, hepatoprotection, and S1 P accumulation. RESULTS: S1 P accumulated in the HA-S1 P group livers more than S1 P group livers. Serum ALT levels, TUNEL-positive hepatocytes, and expression of cleaved caspase-3 expression, were significantly decreased in the HA-S1 P group. TEM revealed that the liver sinusoidal endothelial cell(LSEC) lining was preserved in the HA-S1 P group. Moreover, the HA-S1 P group showed a greater increase in the HO-1 protein levels compared to the S1 P group.CONCLUSION: Our results suggest that HA-S1 P exhibits cytoprotective effects in the liver through the inhibition of LSEC apoptosis. HA-S1 P is an effective agent for hepatic ischemia/reperfusion injury. | Naoki Sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama Tomohito Tanoi Soichiro Murata Yu Sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi | 2015 | World Journal of Gastroenterology2015，21，45： | 1 |
| 2 | Comparison of Patient-Controlled Epidural Analgesia With and Without Background Infusion After Gastrectomy显示文摘 | Hiroshi Komatsu Shigeru Matsumoto Hiromasa Mitsuhata Kyoko Abe Sohachi Toriyabe | 1998 | Anesthesia & Analgesia1998，，4： | 1 |
| 3 | Biofilm formation on rat skin wounds by Pseudomonas aeruginosa carrying the green fluorescent protein gene 显示文摘 | Kanno E Toriyabe S Zhang Lian-bo | 2010 | Exp Dermatol2010，19，： | 1 |
| 4 | Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region显示文摘 | Yoshinari K Yoda N Toriyabe T | 2010 | Biochem Pharmacol2010，79，2： | 1 |
| 5 | Unveiling a new essential cis element for the transaetivation of the CYP3A4 gene by xenobioties显示文摘 | Toriyabe T Nagata K Takada T | 2009 | Mol Pharmacol2009，75，3： | 1 |
| 6 | Versatility of chimeric/lap based on thoracodorsal vessels incorporating vascularized scapular bone and latissimus dorsi myoeutaneous flap in reconstructing lower extremity bone defects due to osteomyelitis显示文摘 | Tachi M Toriyabe S Imai Y | 2010 | J Reconstr Microsurg2010，26，6： | 1 |
| 7 | Differentiation be- tween benign and metastatic cervical lymph nodes with ultra- sound 显示文摘 | Toriyabe Y Nishimura T Kita S | 1997 | Clin Radiology1997，52，12： | 1 |
| 8 | Changes in respiratory pattern and arteial blood gases during sdation with propofol or midazolam in spinal anesthesia显示文摘 | Yamakage M Kamada Y Toriyabe M el at | 1999 | J Clin Anesth1999，11，5： | 1 |
| 9 | The activation of 5-HT3 receptors evokes GABA release in the spinal cord显示文摘 | Kawamata T Omote K Toriyabe M | 2003 | Brain Res2003，978，： | 1 |
| 10 | Biofilm formation on rat skin wounds by Pseudomonas aeruginosa carrying the green fluorescent protein gene显示文摘 | Kanno E Toriyabe S Zhang L | 2010 | Exp Dermatol2010，19，： | 1 |
| 11 | Versatility of chimeric flap based on thoracodorsal vessels incorporating vascularized scapular bone andlatissimus dorsi myocutaneous flap in re- constructing lower-extremity bone defects due to osteomyeli- tis显示文摘 | Tachi M Toriyabe S Imai Y | 2010 | J Reconstr Microsurg2010，26，6： | 1 |
| 12 | Case of true and false median cleft with polypoid masses in the facial midline显示文摘 | Imai Y Seino H Toriyabe S | 2007 | Cleft Palate Craniofac J2007，44，6： | 1 |
| 13 | Differentiation between benign and metastatic cervical lymph nodes with ultrasound 显示文摘 | Toriyabe Y Nishimuva T Kita S | 1997 | Clinical Radiology1997，52，12： | 1 |
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