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| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | Intratumor genomie heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases 显示文摘 | Torres L Ribeiro FR Pandis N | 2007 | Breast Cancer Res Treat2007，102，2： | 1 |
| 3 | Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation显示文摘 | Torres SR Fr?de TS Nardi GM | 2000 | Eur J Pharmacol2000，408，2： | 1 |
| 4 | Retrograde ureteroscopic endopyelotomy显示文摘 | Mendez - Torres FR Urena R Thomas R | 2004 | Urol Clin North Am2004，31，1： | 1 |
| 5 | Biomarkers assessment in juvenile Cyprinus carpio to waterborne cadmium显示文摘 | Torre FR Salibia AA Ferraric L | 2000 | Environ Pollut2000，，109： | 1 |
| 6 | The mitochondrial genome of the blowfly Chrysomya chloropyga (Diptera:Calliphoridae)显示文摘 | Junqueira AC Lessinger AC Torres TT Silva FR da Vettore AL Arruda P Espin AMLA | | 0，，： | 1 |
| 7 | Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases显示文摘 | Torres L Ribeiro FR Pandis N Andersen JA Heim S Teixeira MR | | 0，，02： | 1 |
| 8 | Tadpoles assay: its application to a water toxicity assessment of a polluted urban river 显示文摘 | Demichelis SO Dela Torre FR Ferrari L Garcia ME Salibian A | 2001 | Environmental Monitoring and Assessment2001，68，： | 1 |
| 9 | Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer显示文摘 | Cristina Frías Cristina García-Aranda Carmen De Juan Alberto Morán Paloma Ortega Ana Gómez Florentino Hernando Jose-Antonio López-Asenjo Antonio-José Torres Manuel Benito Pilar Iniesta | 2007 | Lung Cancer2007，，3： | 1 |
| 10 | Ulcerative colitis as a progressive disease: The forgotten evidence显示文摘 | Joana Torres Vincent Billioud David B. Sachar Laurent Peyrin‐Biroulet Jean‐Frédéric Colombel | 2011 | Inflamm Bowel Dis2011，，： | 1 |
| 11 | Optimizing treatment outcomes in severe community-acquired pneumonia显示文摘 | de Castro FR Torres A | 2003 | Am J Respir Med2003，2，1： | 1 |
| 12 | Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras显示文摘 | Kobayashi E Santos NF Torres FR | 2003 | Arch Neurol2003，60，11： | 1 |
| 13 | Optimizing treatment outcomes in severecommunity acquired pneumonia显示文摘 | de Castro FR Torres A | 2003 | Am J Respir Med2003，2，1： | 1 |
| 14 | Telomere function in colorectal cancer显示文摘Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the western world.Tumour cells acquire the hallmarks of cancer during the carcinogenic selection process.Cell immortality is one of the principal features acquired during this process which involves the stabilization of telomere length.It is achieved mainly,by telomerase activation.Thus,the discovery of telomeres and telomerase allowed an understanding of the mechanisms by which cells can become immortalized.Different studies have shown that tumour cells have shorter telomeres than nontumour cells and have detected telomerase activity in the majority of tumours.Survival studies have determined that telomere maintenance and telomerase activity are associated with poor prognosis.Taking into account all the results achieved by different groups,quantification and evaluation of telomerase activity and measurement of telomere length may be useful methods for additional biologic and prognostic staging of colorectal carcinoma. | Cristina Frías Alberto Morán Carmen de Juan Paloma Ortega Tamara Fernández-Marcelo Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Manuel Benito Pilar Iniesta | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 0 |
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