|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 3 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 4 | Angiogenesis:a target for cancer therapy显示文摘 | Tortora G Melisi D Ciardiello F | 2004 | Curr Pharm Des2004，10，1： | 1 |
| 5 | Gut microbiota and metabolic syndrome显示文摘 | Francesca D’Aversa Annalisa Tortora Gianluca Ianiro Francesca Romana Ponziani Brigida Eleonora Annicchiarico Antonio Gasbarrini | 2013 | Internal and Emergency Medicine2013，，1： | 1 |
| 6 | Direct activation of cardiac pacemak-er channels by intracellular cyclic AMP 显示文摘 | DiFrancesco D Tortora P | 1991 | Nature1991，351，6322： | 1 |
| 7 | A synthetic ligand for IgA affinity purification显示文摘 | PALOMBO G FALCO S D TORTORA M | 1998 | Journal of Molecular Recognition1998，11，16： | 1 |
| 8 | Direct activation of cardiac pace-maker channels by intracellular cyclic AMP显示文摘 | DiFrancesco D Tortora P | 1991 | Nature1991，351，6322： | 1 |
| 9 | Simultaneous Optimization of Tracking Performance and Accommodation of Sensor Faults显示文摘 | Tortora G Kouvaritakis B Clarke D W | 2002 | Int J of Control2002，75，3： | 1 |
| 10 | Angiogenesis:a target for cancer therapy显示文摘 | TORTORA G MELISI D CIARDIELLO F | 2004 | Curr Pharm Des2004，10，1： | 1 |
| 11 | 查看详情显示文摘 | Gorrasi G Tortora M Vittoria V Kaempfer D Mülhaupt R | | 0，，13： | 1 |
| 12 | Response rate and measurement differences in mixed-mode surveys using mail, telephone, interactive voice response and the Internet 显示文摘 | Dillman D A Phelps G Tortora R | 2009 | Social Science Research2009，38，1： | 1 |
| 13 | Simultaneous optimization of tracking performance and accommodation of sensor faults显示文摘 | Tortora G Kouvaritakis B Clarke D W | 2002 | Int J of Control2002，75，1： | 1 |
| 14 | Angiogenesis:a target for cancer therapy显示文摘 | Tortora G Melisi D Ciardiello F | 2004 | Curr Pharm Des2004，10，1： | 1 |
| 15 | Key cancer cell signal transduction pathways as therapeutic targets显示文摘 | Bianco R Melisi D Ciardiello F Tortora G | 2006 | Eur J Cancer2006，42，： | 1 |
| 16 | Direct activation of cardiac pacemaker channels by intracellular cyclic AMP显示文摘 | DiFrancesco D Tortora P | 1991 | Nature1991，351，6322： | 1 |
| 17 | Data-driven grading of brain gliomas : A muhiparametric MR imaging study 显示文摘 | Caulo M Panara V Tortora D | 2014 | Radiology2014，272，2： | 1 |
| 18 | Angiogenesis: A target for cancer therapy 显示文摘 | Tortora G Melisi D Ciardiello F | 2004 | Ingenta2004，10，1： | 1 |
| 19 | A novel needle guide system to perform percutaneous laser abla- tion of liver tumors using the multifiber technique 显示文摘 | Di Costanzo GG D'Adamo G Tortora R | 2013 | Acta Radiol2013，54，8： | 1 |
| 20 | Response Rate and Measurement Differences in Mixed--Mode Surveys Using Mail, Telephone, Interaetive Voiee Response (IVR) and the Internet显示文摘 | Dillman D A Phelps G Tortora R | 2009 | Social Science Research2009，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员