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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a widespread pathology described for the first time by Alois Alzheimer in 1907.It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive functions,whose prevalence is estimated to grow due to the increasing life expectancies all over the world.To date,the only treatments available for this disease are symptomatic and no actual effective cure is available.The main effect of the drugs commonly used in therapeutic protocols is to temporarily delay the onset of the disease and to slightly improve the patients’cognitive capabilities(Piemontese,2017)(Figure 1). | Leonardo Brunetti Antonio Laghezza Fulvio Loiodice Paolo Tortorella Luca Piemontese | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 3 | TRANSFORMING GROWTH FACTOR β1 AND SOLUBLE FAS SERUM LEVELS IN HEPATOCELLULAR CARCINOMA显示文摘 | Rodolfo Sacco Domenico Leuci Cosimo Tortorella Giorgio Fiore Felice Marinosci Salvatore Antonaci | 2000 | Cytokine2000，，6： | 2 |
| 4 | Metabolic changes in neuronal migration disorders:evaluation by combined MRI and proton MR spectroscopy显示文摘 | Simone IL Federico F Tortorella C | 1999 | Epilepsia1999，40，7： | 1 |
| 5 | sICAM-1, sCD95 and sCD95L levels in chronic liver diseases of different etiology显示文摘 | Tortorella C Sacco R Orlando P | 2000 | Immunopharmacol Immunotoxicol2000，22，1： | 1 |
| 6 | Viral subversion of the immune system显示文摘 | Tortorella D Gewurz BE Furman MH | 2000 | Annu Rev Immunol2000，18，1： | 1 |
| 7 | TIMP-3 is a potent inhibitor of aggrecanase1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)显示文摘 | Tortorella M Nagase H | 2001 | J Biol Chem2001，276，12： | 1 |
| 8 | Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans显示文摘 | TORTORELLA C SIMONE O PIAZZOLLA G | | 0，，11： | 1 |
| 9 | Characterization of proteins in detergent-resistant membrane complexes from Madin-Darby canin kidney epithelial cells显示文摘 | Melkonian KA Chu T Tortorella LB | 1995 | Biochemistry1995，3，16： | 1 |
| 10 | Immunoresponsiveness in chronic hepatitis C patients; correlation between tissue and serum findings显示文摘 | Piazzolla G Tortorella C Fiore G | 1998 | Immunopharmacol Immunotoxicol1998，20，3： | 1 |
| 11 | Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome显示文摘 | Ranieri VM Suter PM Tortorella C | 1999 | JAMA1999，282，1： | 1 |
| 12 | Relationship between in-terferon-gamma,interleukin-10,andinterleukin-12 production in chronic hepatitis C and invitroeffects of interferon -alpha显示文摘 | Piazzolla G Tortorella C Schiraldi O | 2000 | J Clin Immunol2000，20，1： | 1 |
| 13 | Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis显示文摘 | Filippi M Tortorella C Rovaris M | 2000 | J Neurol Neurosurg Psychiatry2000，68，： | 1 |
| 14 | Metabolic chan- ges in neuronal migration disorders: evaluation by combined MRI and proton Mrspectroscopy显示文摘 | Simone IL Federico F Tortorella C | 1999 | Epilepsy1999，40，： | 1 |
| 15 | Localised ^1H- MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV显示文摘 | Simone IL Federico F Tortorella C | 1998 | J Neurol Neurosurg Psychiatry1998，64，4： | 1 |
| 16 | Improved reliability- prediction and field-reliability-data analysis for field-replaceable units 显示文摘 | JACKSON D S PANT H TORTORELLA M | 2002 | IEEE Transactions on Reliability2002，51，1： | 1 |
| 17 | Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome:a randomized controlled trial显示文摘 | Ranieri VM Suter PM Tortorella C | | 0，，： | 1 |
| 18 | Human adrenal cortex andaldosterone secreting adenomas express both 11 beta - hydroxysteroid dehydrogenase type 1 and type 2genes 显示文摘 | Albertin G Tortorella C Malendowicz LK | 2002 | Int J Mol Med2002，9，5： | 1 |
| 19 | Purification and cloning of aggrecanase-1:a member of the ADAMTS family of pro-teins显示文摘 | Tortorella MD Burn TC Pratta MA Abbaszade I | | 0，，5420： | 1 |
| 20 | Classification of food, beverages and perfumes by WO 3 thin-film sensors array and pattern recognition techniques显示文摘 | M. Penza G. Cassano F. Tortorella G. Zaccaria | 2001 | Sensors & Actuators: B. Chemical2001，，1： | 1 |
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