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| 1 | The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models显示文摘Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the disease.Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets.In order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its phases.In this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models. | Rui C.Oliveira Ana Margarida Abrantes JoseGuilherme Tralhao Maria Filomena Botelho | 2020 | Animal Models and Experimental Medicine2020，3，1： | 5 |
| 2 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer 显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 3 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 4 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M Evaristo C Schonherr E Kayal S | 2003 | FASEB J2003，17，3： | 1 |
| 5 | MRi-conditional pacemakers:current perspectives显示文摘 | Ferreira A M Costa F Tralhao A | 2014 | Med Devices(Auckl)2014，7，5： | 1 |
| 6 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 7 | In vivo selective and distant killing of cancer cells using adenovirus2mediated decorin gene transfer显示文摘 | Tralhao J G Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 8 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 9 | In vivo selective and distant killing of cancer cells using adenovirusmediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 10 | Study of perioperative liver function by dynamic monitoring of ICG-clearance 显示文摘 | Tralhao JG Hoti E Oliveiros B | 2012 | Hepatogas-troenterology2012，59，： | 1 |
| 11 | In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer显示文摘 | Tralhao JG Schaefer L Micegova M | 2003 | FASEB J2003，17，3： | 1 |
| 12 | Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice显示文摘AIM: To analyze the modulation of gene expression profi le associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice. METHODS: Microarray technology was performed on liver tissue obtained from 4 control (LacZ) and 4 transgenic mice (HBx-LacZ),48 h after partial hepatectomy. The significance of the normalized log-ratios was assessed for each gene,using robust t-tests under an empirical Bayes approach. Microarray hybridization data was verified on selected genes by quantitative PCR. RESULTS: The comparison of gene expression patterns showed a consistent modulation of the expression of 26 genes,most of which are implicated in liver regeneration. Up-regulated genes included DNA repair proteins (Rad-52,MSH6) and transmembrane proteins (syndecan 4,tetraspanin),while down-regulated genes were connected to the regulation of transcription (histone deacetylase,Zfp90,MyoD1) and were involved in the cholesterol metabolic pathway and isoprenoid biosynthesis (farnesyl diphosphate synthase,Cyp7b1,geranylgeranyl diphosphate synthase,SAA3). CONCLUSION: Our results provide a novel insight into the biological activities of HBx,implicated in the inhibition of liver regeneration. | Malgorzata Sidorkiewicz Jean-Philippe Jais Guilherme Tralhao Serban Morosan Carlo Giannini Nicolas Brezillon Patrick Soussan Oona Delpuech Dina Kremsdorf | 2008 | World Journal of Gastroenterology2008，14，4： | 1 |
| 13 | Resection of hepatocellular carcinoma:the effect of surgical margin and blood transfusion on long-term survival:Analysis of 209 consecutive patients显示文摘 | Tralhao JG Kayal S Dagher I | 2007 | Hepatogastroenterology2007，54，76： | 1 |
| 14 | A multi-objective approach to locate emergency shelters and identify evacuation routes in urban areas显示文摘 | Luis Alcada-Almeida Lino Tralhao Luis Santos | 2009 | Geographical analysis2009，41，： | 1 |
| 15 | Study of Perioperative Liver Function by Dynamic Monitoring of ICG-Clearance显示文摘 | Tralhao JG Hoti E Oliveiros B | | 0，，116： | 1 |
| 16 | Hepatic extraction frac- tion : interest of its quantification in patients with hepatic tumours 显示文摘 | Tralhao JG Abrantes AM Hoti E | 2012 | Hepato-gastroenterology2012，59，117： | 1 |
| 17 | A Muhiobjective Approach to Locate Emergency Shelters and Iden- tify Evacuation Routes in Urban Areas显示文摘 | Luis Alcada - Almeida Lino Tralhao Luis Santos Joao Coutinho - Rodrignes | 2009 | Geographical Analysis2009，41，： | 1 |
| 18 | Solving a Location - routing Problem with a Multiobjective Approach : the De- sign of Urban Evacuation Plans显示文摘 | Joao Coutinho - Rodrigues Lino Tralhao Lufs Alqada - Almeida | 2012 | Journal of Transport Geography2012，22，： | 1 |
| 19 | A Multi objeclive approach to locate emergency shelters and identify evacuation routes in urban areas 显示文摘 | Almeida L A Tralhao L Santos L | | Geographical analysis0，49，1： | 1 |
| 20 | A Multiobjective Approach to Locate Emergency Shelters and I- dentify Evacuation Routes in Urban Areas显示文摘 | Luis Alcada- Almeida Lino Tralhao Luis Santos Joao Coutinho- Rodrigues | 2009 | Geographical Analysis2009，41，： | 1 |
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