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| 1 | 急性脑梗死静脉溶栓治疗中凝血相关指标变化显示文摘目的:探讨纤维蛋白原、纤维蛋白降解产物、D-二聚体等凝血相关指标在急性缺血性脑卒中(AIS)静脉溶栓前后的改变。方法:选择80例发病后7h静脉内溶栓的急性大脑中动脉供血区AIS病例,观察溶栓前、溶栓后2h、溶栓后24h的凝血相关指标变化。结果:在AIS溶栓治疗中,纤维蛋白原在溶栓后2h较溶栓前降低(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.05);纤维蛋白溶解产物在溶栓后2h较溶栓前升高(P<0.01),溶栓24h后下降(P<0.01);D-二聚体在溶栓后2h较溶栓前升高(P<0.01),溶栓24h后降低(P<0.01),但仍高于溶栓前(P<0.01);ⅩⅢ因子水平在溶栓24h后明显下降(P<0.01);α2-抗纤溶酶水平在溶栓后2h较溶栓前下降(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.01);纤溶酶原水平在溶栓后2h较溶栓前下降(P<0.01),溶栓24h后上升(P<0.01),但仍低于溶栓前水平(P<0.01);血小板在溶栓治疗后低于溶栓前,尤其是溶栓24h后(P<0.05)。结论:在AIS溶栓治疗中,纤维蛋白原、ⅩⅢ因子、α2-抗纤溶酶、纤维蛋白溶解酶原、D-二聚体、纤维蛋白降解产物及血小板都发生明显变化,与纤溶作用机制相符。 | 孙旭红 Paul Trouillas Miche Berthiller Michel Hanss 李威 翟宇 | 2011 | 中国临床神经科学2011，19，5： | 6 |
| 2 | 不同剂量重组组织纤溶酶原激活剂静脉溶栓对急性脑梗死后凝血指标的影响显示文摘目的:观察不同剂量重组组织纤溶酶原激活剂(rt-PA)对急性脑梗死静脉溶栓后纤维蛋白原、纤维蛋白降解产物、D-二聚体等凝血指标的影响。方法:选择80例发病后7 h静脉溶栓的急性大脑中动脉供血区脑梗死患者,随机分为rt-PA 0.8 mg/kg和0.9 mg/kg静脉溶栓治疗组各40例。分别在溶栓前、溶栓后2 h,溶栓后24 h静脉采血,观察2组纤维蛋白原、纤维蛋白溶解产物、D-二聚体、凝血因子ⅩⅢ、α2-抗纤溶酶、纤溶酶原和血小板水平。结果:rt-PA 0.8 mg/kg组和0.9 mg/kg组患者纤维蛋白原、纤维蛋白溶解产物、D-二聚体、凝血因子ⅩⅢ、α2-抗纤溶酶、纤溶酶原和血小板水平差异均无统计学意义(P>0.05)。结论:rt-PA 0.8 mg/kg组和0.9 mg/kg组患者溶栓后凝血指标均无明显不同;脑梗死患者可考虑推荐使用rt-PA0.8 mg/kg为药物使用的单位计量。 | 孙旭红 Paul Trouillas Michel Bertiller Michel Hanss 李威 刘建仁 | 2013 | 蚌埠医学院学报2013，38，6： | 6 |
| 3 | Sex-related difference in the growth of prolacfinomas:a clinical and proliferation marker study显示文摘 | TROUILLAS J MAITER D | 1997 | J Clin Endocrinol Metab1997，82，7： | 1 |
| 4 | Thrombolysis with intravenous rtPA in a series of 100 cases of acute carotid territory stroke:determination of etiological,topographic,and radiological outcome factors显示文摘 | Trouillas P Nighoghossian N Derex L | 1998 | Stroke1998，29，： | 1 |
| 5 | Early fibrinogen degrada-tion coagulopathy is predictive of parenchymal hematomas in cerebral rt-PA thrombolysis:a study of 157 cases显示文摘 | Trouillas P Dercx L Philippeau F | 2004 | Stroke2004，35，： | 1 |
| 6 | Early fibrin ogen degradation coagulopathy is predictive of paren- chymal hematomas in cerebral rt-PA thrombolysis a study of 157 cases显示文摘 | Trouillas P Derex L Philippeau F | 2004 | Stroke2004，35，6： | 1 |
| 7 | Hyperbaric oxygen in the treatment of acute ischemic stroke显示文摘 | NIGHOGHOSSIAN N TROUILLAS P | 1997 | J Neurol Sci1997，150，： | 1 |
| 8 | Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion 显示文摘 | TROUILLAS J DANIEL L GUIGARD M P | 2003 | J Neurosurg2003，98，5： | 1 |
| 9 | Hyperbaric oxygen in the treatment of acute ischemic stroke: an unsettled issue 显示文摘 | Nighoghossian N Trouillas P | 1997 | Neurol Sci1997，150，1： | 1 |
| 10 | Open trial of intravenous tissue plasminogen activator in acute carotid territory storke correlations of outcome with clinical and radiological data显示文摘 | Nighossian N Getenet JC | 1996 | Stroke1996，27，5： | 1 |
| 11 | Antioxidant, anti-inflammatory and antiproliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas显示文摘 | Patrick Trouillas Claude-Alain Calliste Daovy-Paulette Allais Alain Simon Abdelghafour Marfak Christiane Delage Jean-Luc Duroux | 2002 | Food Chemistry2002，，3： | 1 |
| 12 | Hyperbaric oxygen in the treatment of acute ischemic stroke:an unsettled issue显示文摘 | Nighoghossian N Trouillas P | 1997 | J Neurol Sci1997，150，1： | 1 |
| 13 | A six-locus phylogeny reveals high levels of species diversity in Botryosphaeriaceae from California almond 显示文摘 | Inderbitzin P Bostock R Trouillas F P | 2010 | Mycologia2010，102，6： | 1 |
| 14 | Hyperbaric oxygen in the treatment of acute ischemic stroke显示文摘 | Nighoghossian N Trouillas P Adeleine P | 1995 | Stroke1995，26，3： | 1 |
| 15 | A six locus phylogeny reveals high species diversity in Botryosphaeriaceae from California almond显示文摘 | Inderbitzin P Bostock RM Trouillas FP | 2010 | Mycologia2010，102，6： | 1 |
| 16 | Classification andpathogenesis of cerebral hemorrhages afterthrombolysis in ischemic stroke显示文摘 | Trouillas P von Kummer R | 2006 | Stroke2006，37，： | 1 |
| 17 | Taxonomy and DNA phylogeny of diatrypaceae associated with Vinis vinifera and other woody plants in Australia 显示文摘 | Trouillas F P Pitt W M Sosnowski M R | 2011 | Fungal Divers2011，49，： | 1 |
| 18 | Nuclear hemodynamic vertebrobasilar insufficiency显示文摘 | Trouillas P Nighoghossian N Philippon B | 1991 | Arch Nenrol1991，48，12： | 1 |
| 19 | Early fibrinogen degrada- tion eoagulopathy is predictive of parenchymal hematomas in cerebral rt- PA thrombolysis a study of 157 cases 显示文摘 | Trouillas P Derex L Philippeau F | 2004 | Stroke2004，35，6： | 1 |
| 20 | Apoptosis and differentiation commitment:noeel insights revealed by gene protiling studies in mouse embryonic stem cells 显示文摘 | Eural D Trouillas M | 2006 | Cell Death Differ2006，13，4： | 1 |
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