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| 1 | 变网格间距速度层析成像方法显示文摘变网格间距速度层析成像,是指反演网格模型中采用不同的网格间距反演地下地层的速度分布,它可以在观测数据较少的情况下,提高浅部地层速度反演的分辨率和深层速度反演的精度。变网格间距与规则网格间距速度层析成像方法类似,但有两个最主要的不同之处:射线正演网格单元的射线段被划分到相应的较大反演网格单元中,平滑约束方程在变网格间距界面的上一平面和下一平面的网格处需要做出适当的修改。文中首先采用变网格方法对二维和三维检测板模型进行恢复测试,反演结果对大、小异常体的刻画效果均比规则网格方法好;然后,采用变网格方法对实际资料进行走时反演,反演结果对两个低速异常区的刻画比规则网格方法的效果好。因此,变网格方法反演的速度剖面分辨率较高,尤其对浅部地层的速度成像效果具有较大的改善作用;另外,在观测数据较少的情况下,通过调整不同网格的数量比例,变网格反演方法还可以克服层析成像过程中解的欠定问题。 | 黄光南 刘洋 Ari Tryggvason 胡光义 范廷恩 董建华 | 2013 | 石油地球物理勘探2013，48，3： | 13 |
| 2 | 21世纪的工程教育重构显示文摘工程教育与产业正面临着新挑战。有人认为这是工程教育的危机,也有人认为这是我们步入21世纪为工程教育带来的机遇。客观地讲,没有人对工程教育的现状以及短期内面临的问题十分满意。正如狄更斯在《双城记》开头中写到,“现在是最好的时候,也是最糟的时刻”。 | Gretar Tryggvason Diran Apelian 查建中 冯磊 | 2008 | 中国大学教学2008，，12： | 8 |
| 3 | Searching for a treatment for Alport syndrome using mouse models显示文摘Alport syndrome(AS) is a hereditary nephritis caused by mutations in COL4A3,COL4A4 or COL4A5 encoding the type IV collagen α3,α4,and α5 chains,which are major components of the glomerular basement membrane.About 20 years have passed since COL4A3,COL4A4,and COL4A5 were identified and the first Alport mouse model was developed using a knockout approach.The phenotype of Alport mice is similar to that of Alport patients,including characteristic thickening and splitting of the glomerular basement membrane.Alport mice have been widely used to study the pathogenesis of AS and to develop effective therapies.In this review,the newer therapies for AS,such as pharmacological interventions,genetic approaches and stem cell therapies,are discussed.Although some stem cel therapies have been demonstrated to slow the rena disease progression in Alport mice,these therapies demand continual refinement as research advances.In terms of the pharmacological drugs,angiotensin-converting enzyme inhibitors have been shown to be effective in Alport mice.Novel therapies that can provide a better outcome or lead to a cure are still awaited. | Kan Katayama Shinsuke Nomura Karl Tryggvason Masaaki Ito | 2014 | World Journal of Nephrology2014，3，4： | 5 |
| 4 | DIRECT NUMERICAL SIMULATIONS OF MULTIPHASE FLOWS显示文摘Direct numerical simulations have recently emerged as a viable tool to study finite Reynolds number multiphase flows. The approach parallels direct numerical simulations of turbulent flows, but the unsteady motion of a deformable phase boundary adds considerable complexity. Here, a front tracking method that has been used to study several multiphase flow problems is described. The Navier Stokes equations are solved by a finite difference/front tracking technique that allows the inclusion of fully deformable interfaces and surface tension, in addition to inertial and viscous effects. A parallel version of the method makes it possible to use large grids and resolve flows containing a few hundred bubbles. | G. Tryggvason A. Esmaeeli A. Fernandez J. LuDepartment of Mechanical Engineering, Worcester Polytechnic Institute, 100 InstituteRoad, Worcester, MA 01609, USA | 2001 | Transactions of Nanjing University of Aeronautics and Astronautics2001，18，z1： | 4 |
| 5 | A formulaic approach to translation at the post office: reading the signs显示文摘 | Alison Wray Stephen Cox Mike Lincoln Judy Tryggvason | 2003 | Language and Communication2003，，1： | 2 |
| 6 | Nephrina unique structural and signaling protein of kidney filter显示文摘 | Patrakka J Tryggvason K | 2007 | Trends Mol Med2007，13，9： | 1 |
| 7 | Nephrin-a unique structuraland signaling protein of the kidney filter显示文摘 | PatrakkaJ Tryggvason K | 2007 | Trends MolMed2007，13，9： | 1 |
| 8 | Unraveling the molecular make-up of the glomemlar podocyte slit diaphragm 显示文摘 | KHOSHNOODI J TRYGGVASON K | 2001 | Exp Nephrol2001，9，6： | 1 |
| 9 | Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology显示文摘 | Lwaki Ebarasi Asmundur Oddsson Kjell Hultenby Christer Betsholtz Karl Tryggvason | 2011 | Current Opinion in Nephrology and Hypertension2011，，4： | 1 |
| 10 | Numerical simulation of dendritic solidification with convection: Three-dimensional flow显示文摘 | AL-RAWAHI N TRYGGVASON G | 2004 | Journal of Computational Physics2004，194，： | 1 |
| 11 | Dynamics of homogeneous bubbly flow, Part 2:Velocity fluctuations 显示文摘 | Bunner B Tryggvason G | 2002 | J Fluid Mech2002，466，： | 1 |
| 12 | Metastatic potentialcorrelates with enzymatic degradation of basement membrane colla-gen显示文摘 | Liotta L A Tryggvason K Garbisa S | 1980 | Nature1980，28，4： | 1 |
| 13 | Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm 显示文摘 | Tryggvason K | 1999 | J Am Soc Nephrol1999，10，11： | 1 |
| 14 | Unraveling the mechanisms of glomerular ultra- filtration :nephrin,a key component of the slit diaphragm显示文摘 | Tryggvason K | 1999 | J Am Soc Nephrol1999，10，11： | 1 |
| 15 | A novel surgical organ perfusion method for effective ex vivo and in vivo gene transfer into renal glomerular cells显示文摘 | Parpala-Sparman T Lukkarinen O Heikkila P Tryggvason K | 1999 | Urol Res1999，27，2： | 1 |
| 16 | Numerical simulation of dendritic solidification with convection: three-dimensional flow 显示文摘 | Al-Rawahi N Tryggvason G | 2004 | Journal of Computational Physics2004，，194： | 1 |
| 17 | Molecular basis of glomerular permselectivity显示文摘 | Tryggvason K Wartiovaara J | 2001 | Curr Opin Nephrol Hypertens2001，10，： | 1 |
| 18 | Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development显示文摘 | Reponen P Sahlberg C Huhtala P Hurskainen T Thesleff I Tryggvason K | 1992 | J Biol Chem1992，267，11： | 1 |
| 19 | Towards understanding the inherited susceptibility for nephropathy in diabetes 显示文摘 | Thomas MC Groop PH Tryggvason K | 2012 | Curt Opin Nephrol Hypertens2012，21，2： | 1 |
| 20 | Hered- itary proteinuria syndromes and mechanisms of proteinuria 显示文摘 | Tryggvason Karl Patrakka Jaakko Wartiovaara Jorma | 2006 | The New England journal of medicine2006，354，13： | 1 |
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